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Benign Tumors and Tumorous Conditions of the Bone

  • Yong-Whee BahkEmail author
Chapter

Abstract

Benign tumors originating from the bone, cartilage, fibrous tissue, vessels, and unknown tissues are one of the most interesting objectives of pinhole scintigraphy. Such tumors include osteoma, osteoid osteoma, osteoblastoma, chondroma, enostosis, chondroblastoma, fibrous cortical defect and nonossifying fibroma, osteochondroma, primary bone cysts, giant cell tumor, and others. Another large group of bone diseases, in the diagnosis of which 99mTc-MDP scanning is beneficial, are tumorous conditions.

References

  1. Abdel-Dayem HM, Papademetriou T (1981) Subperiosteal hemorrhage in neurofibromatosis: appearance in scintigraphy. Clin Nucl Med 6:272CrossRefPubMedGoogle Scholar
  2. Azous EM, Saigal G, Rodriguez MM et al (2005) Langerhans’ cell histiocytosis: pathology, imaging and treatment of skeletal involvement. Pediatr Radiol 35:103–115CrossRefGoogle Scholar
  3. Baek JH, Lee SY, Kim SH et al (1997) Pinhole bone scintigraphic manifestation of fibrous dysplasia. Korean J Nucl Med 31:452–458Google Scholar
  4. Bahk YW (1964) Dyschondroplasia with hemangiomata (Maffucci’s syndrome). Radiology 82:407–410CrossRefPubMedGoogle Scholar
  5. Bahk YW, Park YH, Chung SK, Chi JG (1995) Bone pathological correlation of multimodality imaging in Paget’s disease. J Nucl Med 36:1421–1426PubMedGoogle Scholar
  6. Becelli R, Carboni A, Gianni C, Alterio A, Renzi G (2002) A rare condition of Hand-Schuller-Christian disease. J Craniofac Surg 13:759–761CrossRefPubMedGoogle Scholar
  7. Benli IT, Akalin S, Boysan E et al (1992) Epidemiological, clinical and radiological aspects of osteopoikilosis. J Bone Joint Surg Br 74:504–506PubMedGoogle Scholar
  8. Black B, Dooley J, Pyper A, Reed M (1993) Multiple hereditary exostoses. An epidemiologic study of an isolated community in Manitoba Clin Orthop Relat Res 287:212–217Google Scholar
  9. Büll U, Keyl W, Meister P et al (1981) Wertigkeit der “Region-of interest”—Technik in der skelettszintigraphischen Diagnostik primärer Knochentumoren. Radiologe 21:46–51PubMedGoogle Scholar
  10. Conklin JJ, Camargo EE, Wagner H Jr (1981) Bone scan detection of peripheral periosteal leiomyoma. J Nucl Med 22:97PubMedGoogle Scholar
  11. Crawford AH Jr, Bagamery N (1986) Osseous manifestations of neurofibromatosis in childhood. J Pediatr Orthop 6:72–88CrossRefPubMedGoogle Scholar
  12. Crone-Munzebrock W, Brassow F (1983) A comparison of radiographic and bone scan findings in histiocytosis X. Skelet Radiol 9:170–173CrossRefGoogle Scholar
  13. D’Ambrosia R, Ferguson AB Jr (1968) The formation of osteochondroma by epiphyseal cartilage transplantation. Clin Orthop Relat Res 61:103–115CrossRefPubMedGoogle Scholar
  14. Dahlin DC, Unni KK (1986a) Osteoid osteoma. In: Bone tumors, 4th edn. Thomas, SpringfieldGoogle Scholar
  15. Dahlin DC, Unni KK (1986b) Chondroma. In: Bone tumors, 4th edn. Thomas, SpringfieldGoogle Scholar
  16. Davila JA, Amrami KK, Sundaram M et al (2004) Chondroblastoma of the hands and feet. Skelet Radiol 33:582–587CrossRefGoogle Scholar
  17. Doyle T, Gunn J, Anderson G et al (2002) Paget’s disease in New Zealand: evidence for declining prevalence. Bone 31:616–619CrossRefPubMedGoogle Scholar
  18. Dupree WB, Enzinger FM (1986) Fibro-osseous pseudo-tumor of the digits. Cancer 58:2103–2109CrossRefPubMedGoogle Scholar
  19. Epstein DA, Levin EJ (1978) Bone scintigraphy in hereditary multiple exostoses. AJR Am J Roentgenol 130:331–333CrossRefPubMedGoogle Scholar
  20. Ferracini R, Zorzan A, Mauro PP, Masse G, Masterson EL (1998) Acetabular osteoblastoma: description of a case. Chir Organi Mov 83:413–417PubMedGoogle Scholar
  21. Fitzer PM (1977) Radionuclide angiography—brain and bone imaging in craniofacial dysplasia (CFD): case report. J Nucl Med 18:709–712PubMedGoogle Scholar
  22. Focacci C, Lattanzi R, Iadeluca ML, Campioni P (1998) Nuclear medicine in primary bone tumors. Eur J Radiol 27(Suppl 1):S123–S131CrossRefPubMedGoogle Scholar
  23. Garrison RC, Unni KK, MeLeod RA et al (1982) Chondrosarcoma arising in osteochondroma. Cancer 49:1890–1897CrossRefPubMedGoogle Scholar
  24. Greenspan A (1995) Bone island (enostosis): current concept—a review. Skelet Radiol 24:111–115Google Scholar
  25. Hall FM, Goldberg RP, Davies JAK et al (1980) Scintigraphic assessment of bone islands. Radiology 135:737–742CrossRefPubMedGoogle Scholar
  26. Helms CA, Hattner RS, Vogler JB III (1984) Radionuclide skeletal survey for pediatric neoplasms. Radiology 151:779–785CrossRefPubMedGoogle Scholar
  27. Hudson TM (1984) Scintigraphy of aneurysmal bone cysts. AJR Am J Roentgenol 142:761–765CrossRefPubMedGoogle Scholar
  28. Humphry A, Gilday DL, Brown RG (1980) Bone scintigraphy in chondroblastoma. Radiology 137:497–499CrossRefPubMedGoogle Scholar
  29. Jaffe HL (1958a) Fibrous cortical defect and non-ossifying fibroma. In: Tumors and tumorous conditions of the bones and joints. Lea & Febiger, Philadelphia, pp 76–91Google Scholar
  30. Jaffe HL (1958b) Solitary bone cyst. In: Tumors and tumorous conditions of the bones and joints. Lea & Febiger, Philadelphia, pp 63–75Google Scholar
  31. Jee WH, Park YK, McCauley TR et al (1999) Chondroblastoma: MR characteristics with pathologic correlation. J Comput Tomogr 23:721–726CrossRefGoogle Scholar
  32. Kaim AH, Hugli R, Bonel HM, Jundt G (2002) Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation. Skelet Radiol 31:88–95CrossRefGoogle Scholar
  33. Keith A (1920) Studies on the anatomical changes which accompany certain growth disorders of the human body. I. The nature of the structural alterations in the disorder known as multiple exostosis. J Anat 54:101–115PubMedPubMedCentralGoogle Scholar
  34. Kim JY, Chung SK, Park YH et al (1992) Pinhole bone scintigraphic appearances of osteoid osteoma. Korean J Nucl Med 26:160–163Google Scholar
  35. Levine E, De Smet AA, Neff JR et al (1984) Scintigraphic evaluation of giant cell tumor of bone. AJR Am J Roentgenol 143:343–348CrossRefPubMedGoogle Scholar
  36. Lichtenstein L (1972) Osteocartilaginous exostosis in: bone tumors, 4rh edn. Mosby, Saint Louis, pp 17–28Google Scholar
  37. Lisbona R, Rosenthall L (1979) Role of radionuclide imaging in osteoid osteoma. AJR Am J Roentgenol 132:77–80CrossRefPubMedGoogle Scholar
  38. McLeod RA, Beabout JW (1973) The roentgenographic features of chondroblastoma. AJR Am J Roentgenol 118:646–471CrossRefGoogle Scholar
  39. Mirra JM (1989a) Fibrohistiocytic tumors of intramedullary origin. In: Mirra JM (ed) Bone tumors. Lea & Febiger, Philadelphia, pp 692–719Google Scholar
  40. Mirra JM (1989b) Aneurysmal bone cyst. In: Mirra JM (ed) Bone tumors. Lea & Febiger, Philadelphia, pp 1267–1331Google Scholar
  41. Mirra JM (1989c) Eosinophilic granuloma. In: Mirra JM (ed) Bone tumors. Lea & Febiger, Philadelphia, pp 1023–1045Google Scholar
  42. Mirra JM (1989d) Giant cell tumors. In: Mirra JM (ed) Bone tumors. Lea & Febiger, Philadelphia, p 958. (Fig. 13.17)Google Scholar
  43. Mirra JM (1989e) Periostitis ossificans. In: Mirra JM (ed) Bone tumors. Lea & Febiger, Philadelphia, pp 1589–1605Google Scholar
  44. Mirra JM, Eckhardt JJ (1989) Enchondroma versus chondrosarcoma. In: Mirra JM (ed) Bone tumors. Lea & Febiger, Philadelphia, pp 476–531Google Scholar
  45. Mirra JM, Gold RH (1989) Fibrous dysplasia. In: Mirra JM (ed) Bone tumors. Lea & Febiger, Philadelphia, pp 191–226Google Scholar
  46. Mungovan JA, Tung GA, Lambiase RE et al (1994) Tc-99 m MDP uptake in osteopoikilosis. Clin Nucl Med 19:6–8CrossRefPubMedGoogle Scholar
  47. Nadel HT, Rossleigh MA (1995) Tumor imaging. In: Treves ST (ed) Pediatric nuclear medicine, 2nd edn. Springer, Berlin Heidelberg New York, pp 496–527CrossRefGoogle Scholar
  48. Neumann RD, Kemp JD, Weiner RE (1995) Gallium-67 imaging for detection of malignant disease. In: Sandler MP et al (eds) Diagnostic nuclear medicine, 3rd edn. Williams and Wilkins, Baltimore, pp 1243–1260Google Scholar
  49. Nishio J, Iwasaki H, Soejima O et al (2002) Rapidly growing fibro-osseous pseudotumor of the digits mimicking extraskeletal osteosarcoma. J Orthop Sci 7:410–413CrossRefPubMedGoogle Scholar
  50. O’Connell JX, Nanthakumar SS, Nielsen GP, Rosenberg AE (1998) Osteoid osteoma: the uniquely innervated bone tumor. Mod Pathol 11:175–180PubMedGoogle Scholar
  51. Ochsner PE (1978) Multiple cartilaginous exostoses and neoplastic degeneration: review of the literature. Z Orthop Ihre Grenzgeb 116:369–378PubMedGoogle Scholar
  52. Parker BR, Pinckney L, Etcubanas E (1980) Relative efficacy of radiographic and radionuclide bone surveys in the detection of the skeletal lesions of histiocytosis X. Radiology 134:377–380CrossRefPubMedGoogle Scholar
  53. Patel MR, Desai SS (1986) Pseudomalignant osseous tumor of soft tissue: a case report and review of the literature. J Hand Surg [Am] 11:66–70CrossRefGoogle Scholar
  54. Pierz KA, Stieber JR, Kusumi K, Dromans JP (2002) Hereditary multiple exostoses: one center’s experience and review of etiology. Clin Orthop Relat Res 401:49–59CrossRefGoogle Scholar
  55. Pinkas L, Robinson D, Halpern N et al (2001) 99mTc-MIBI scintigraphy in musculoskeletal tumors. J Nucl Med 42:33–37PubMedGoogle Scholar
  56. Rambeloarisoa J, el Guedj M, Legeai-Mallet L et al (2002) Hereditary multiple exostoses after 40 years of development: a case report. Rev Med Interne 23:657–664CrossRefPubMedGoogle Scholar
  57. Resnick D, Niwayama G (1988) Enostosis, hyperostosis, and periostitis. In: Resnick D, Niwayama G (eds) Diagnosis of bone and joint disorders, 2nd edn. Saunders, Philadelphia, pp 4073–4139Google Scholar
  58. Revel PA (1986) Paget’s disease of bone. In: Pathology of bone. Springer, Berlin Heidelberg New York, pp 147–167CrossRefGoogle Scholar
  59. Roodman GD, Windle JJ (2005) Paget disease of bone. J Clin Invest 115:200–208CrossRefPubMedPubMedCentralGoogle Scholar
  60. Schaub T, Hahn K (1990) Fibröse dysplasie. In: Brussatis F, Hahn K (eds) Nuklearmedizin in der Orthopädie. Springer, Berlin Heidelberg New YorkGoogle Scholar
  61. Serafini AN (1976) Paget’s disease of the bone. Semin Nucl Med 6:47–58CrossRefPubMedGoogle Scholar
  62. Shi YR, Wu JY, Hsu YA et al (2002) Mutation screening of the EXT genes in patients with hereditary multiple exostoses in Taiwan. Genet Test 6:237–243CrossRefPubMedGoogle Scholar
  63. Sim FH, Dahlin DC, Beabout JW (1975) Osteoid osteoma: diagnostic problems. J Bone Joint Surg Am 63:154–159CrossRefGoogle Scholar
  64. Van Nostrand D, Madewell JE, NcNiesh LM et al (1986) Radionuclide bone scanning in giant cell tumor. J Nucl Med 27:329–338PubMedGoogle Scholar
  65. Waxman AD (1995) Thallium-201 and technetium-99 m methoxyisobutyl isonitrile in nuclear oncology. In: Sandler MP et al (eds) Diagnostic nuclear medicine, 3rd edn. Williams and Wilkins, Baltimore, pp 1261–1274Google Scholar
  66. Westra SJ, van Woerden H, Postma A et al (1983) Radio-nuclide bone scintigraphy in patients with histiocytosis X. Eur J Nucl Med 8:303–306CrossRefPubMedGoogle Scholar
  67. Whyte MP, Murphy WA, Siegel BA (1978) 99mTc-pyrophosphate bone imaging in osteopoikilosis, osteopathia striata, and melorheostosis. Radiology 127:439–443CrossRefPubMedGoogle Scholar
  68. Woldenberg Y, Nash M, Bodner L (2005) Peripheral osteoma of the maxillofacial region. Diagnosis and management: a study of 14 cases. Med Oral Patol Oral Cir Bucal 10(Suppl 2):E139–E142PubMedGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Nuclear Medicine and RadiologySun Ae General HospitalSeoulSouth Korea

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