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Therapeutic Angiogenesis pp 191–216Cite as

Granulocyte Colony-Stimulating Factor

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Abstract

Granulocyte colony-stimulating factor (G-CSF) is a potent hematopoietic protein that promotes the development and function of granulocytes and mobilizes stem/progenitor cells from the bone marrow. Recent studies have shown that G-CSF also directly influences the activity of some non-hematopoietic cells, such as cardiomyocytes, endothelial cells, and neurons via G-CSF receptor. This chapter provides an overview of the preclinical and clinical reports to demonstrate the usefulness and the current limitations of the therapeutic strategy using G-CSF for ischemic diseases.

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Authors and Affiliations

  1. Division of Vascular Regeneration, Unit of Regenerative Medicine, Institute of Biomedical Research and Innovation (IBRI) Hospital, 2-2 Minatojima-Minamimachi, Chuo-Ku, Kobe, Hyogo, 650-0047, Japan

    Yasuyuki Fujita M.D., Ph.D. & Atsuhiko Kawamoto M.D., Ph.D.

  2. Vascular Regeneration Research Group, IBRI Research Center, Kobe, Hyogo, Japan

    Yasuyuki Fujita M.D., Ph.D. & Atsuhiko Kawamoto M.D., Ph.D.

  3. Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Hyogo, Japan

    Yasuyuki Fujita M.D., Ph.D. & Atsuhiko Kawamoto M.D., Ph.D.

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  1. Yasuyuki Fujita M.D., Ph.D.
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  2. Atsuhiko Kawamoto M.D., Ph.D.
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Correspondence to Atsuhiko Kawamoto M.D., Ph.D. .

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  1. Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Yukihito Higashi

  2. Department of Cardiology, Nagoya University, Aichi, Japan

    Toyoaki Murohara

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Fujita, Y., Kawamoto, A. (2017). Granulocyte Colony-Stimulating Factor. In: Higashi, Y., Murohara, T. (eds) Therapeutic Angiogenesis. Springer, Singapore. https://doi.org/10.1007/978-981-10-2744-4_13

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