Abstract
Fisetin (3,7,3′,4′-tetrahydroxyflavone) is a naturally occurring flavonoid that belongs to the flavonol subgroup together with quercetin, myricetin, and kaempferol. It is found in many edible fruits and vegetables like apples, grapes, kiwis, persimmons, strawberries, cucumbers, and onions having various pharmacological properties which include antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-tumorigenic, anti-invasive, and antimetastatic activity (Pal et al. 2015). Reports suggest that it inhibits Wnt/β-catenin, PI3K/AKT/ mTOR, and NFκB signaling pathways (Pal et al. 2013) thus revealing anti-proliferative, pro-apoptotic, and anti-tumorigenic activities against various cancers. It has also been reported to diminish melanoma cell invasion and transition from epithelial to mesenchymal (Pal et al. 2014). It is found to be quickly absorbed and detectable in serum by some murine investigations (Shia et al. 2009).
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Rashid, S. (2017). Chemoprevention by Fisetin. In: Cancer and Chemoprevention: An Overview. Springer, Singapore. https://doi.org/10.1007/978-981-10-2579-2_20
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DOI: https://doi.org/10.1007/978-981-10-2579-2_20
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