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Role of Proteases in Diabetes and Diabetic Complications

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Proteases in Physiology and Pathology

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Abstract

Proteases catalyze the breakdown of proteins by hydrolysis of peptide bonds. These enzymes are involved in a number of pathophysiological processes ranging from the cellular to organism level. These processes include cell growth, homeostasis, remodeling, renewal, division, metabolic pathways, tumor growth, metastasis, etc. A number of proteases are found to be involved in mediating the biochemical pathogenesis of metabolic syndrome such as diabetes and cardiovascular diseases. This chapter summarizes types of proteases, classification, and their proteolytic function in diabetes-associated complications in the kidney, eye, liver, heart, and lung. Understanding the role of proteases will provide insights into the development of preventive and therapeutic modalities for diabetes and diabetic complications.

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Acknowledgement

Authors are thankful to Prof. Ram Rajasekharan, Director, CSIR-CFTRI, for his interest and valuable suggestions. Dr. Ravindra P. V. thanks the Department of Biotechnology, New Delhi, for funding in the form of Ramalingaswami fellowship.

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Authors and Affiliations

  1. Department of Biochemistry, CSIR-CFTRI, Mysuru, 570020, India

    P. V. Ravindra & T. K. Girish

Authors
  1. P. V. Ravindra
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  2. T. K. Girish
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Corresponding author

Correspondence to P. V. Ravindra .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. St. Boniface Hospital Research Centre, University of Manitoba, Faculty of Health Sciences, College of Medicine, Institute of Cardiovascular Sciences, Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla

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Ravindra, P.V., Girish, T.K. (2017). Role of Proteases in Diabetes and Diabetic Complications. In: Chakraborti, S., Dhalla, N. (eds) Proteases in Physiology and Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-10-2513-6_13

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