Stimuli-Responsive Interfaces

pp 127-145


Stimuli-Responsive Structure Control of Self-Assembled Gold Nanoparticles

  • Hideyuki MitomoAffiliated withResearch Institute for Electronic Science, Hokkaido University
  • , Kenichi NiikuraAffiliated withResearch Institute for Electronic Science, Hokkaido University Email author 
  • , Kuniharu IjiroAffiliated withResearch Institute for Electronic Science, Hokkaido University

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Metal nanostructures have attracted a great deal of attention as components of functional materials, and there is a great demand for the development of functional devices composed of these metal nanostructures. In particular, the fabrication of metal nanostructures with dynamic structure control by external stimuli is a major focus. In this chapter, several studies related to “the stimuli-responsive structure control of metal nanostructures” will be introduced, with a particular focus on our own research. Our fabrication strategy is based on self-organization by controlling the surface properties of nanoparticles and tuning their self-assembly through the design and synthesis of surface-modifying ligands. When gold nanoparticles (AuNPs) were modified with fluorinated tetra(ethylene glycol) derivatives, the AuNPs could spontaneously form a well-packed thin film during the drying process or hollow capsules in THF solutions. The AuNP thin film could be transferred onto hydrogel and the intervals in the AuNP array tuned by changes in the size of the gel. One of the potential applications of this tunable plasmonic structure is in sensing devices using surface-enhanced Raman scattering (SERS). This control of the gap distance in the AuNP assembly could effectively work in the SERS detection of proteins, the signal of which was enhanced more than 10-fold in comparison with that of a conventional system. AuNP capsules were cross-linked with PEG to improve the stability of the capsules in water and to give thermo-responsiveness. Cross-linked AuNP capsules showed a rapid response upon light irradiation, suggesting that they have potential applications as a drug delivery carrier with a controlled release function triggered by light.


Gold nanoparticles Self-assembly Active control Plasmon Surface-enhanced Raman scattering Stimuli-responsive Drug delivery system Smart nanodevice