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Calcium Desensitization Mechanism and Treatment for Vascular Hyporesponsiveness After Shock

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Advanced Trauma and Surgery

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Abstract

Shock, the common pathological process of many critical illnesses, is often accompanied by vascular hyporeactivity, which severely interferes with the development and treatment of shock and other critical conditions, especially interferes with the application of vasoactive agents. So, it is very important to shed light on the mechanisms and search for the effective measures. Lots of studies focused on the characteristics of vascular hyporeactivity and mechanisms following shock in recent years. Since the limitation of previous mechanisms for vascular hyporesponsiveness (receptor desensitization mechanism and membrane hyperpolarization mechanism), our research group raised calcium desensitization mechanism for vascular hyporesponsiveness after shock and proposed pertinent treatment measures.

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Authors and Affiliations

  1. State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, People’s Republic of China

    Liangming Liu, Tao Li, Guangming Yang & Chenyang Duan

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  1. Liangming Liu
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  2. Tao Li
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  4. Chenyang Duan
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Correspondence to Liangming Liu .

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  1. Key Laboratory of Wound Repair and Regenerative Medicine of PLA, The first Affiliated Hospital of PLA General Hospital, Beijing, Beijing, China

    Xiaobing Fu

  2. Key Laboratory of Wound Repair and Regenerative Medicine of PLA, Daping Hospital, Chongqing, Chong Qing, China

    Liangming Liu

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Liu, L., Li, T., Yang, G., Duan, C. (2017). Calcium Desensitization Mechanism and Treatment for Vascular Hyporesponsiveness After Shock. In: Fu, X., Liu, L. (eds) Advanced Trauma and Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-10-2425-2_8

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