Inflammation and Fibrosis in ADPKD

  • Hyowon Mun
  • Jong Hoon ParkEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 933)


Diverse signaling pathways have been reported to be associated with polycystic kidney disease (PKD). Cell proliferation is widely known to be an important pathway related to this disease. However, studies on the interactions of inflammation and fibrosis with polycystic kidney disease have been limited. Inflammation is one of the protective systems involved in the response to foreign molecules. In PKD, it was reported that the activity of signaling pathways associated with inflammation is increased. Also, fibrosis is the development of excess fibrous tissue in organ or tissue. It is an abnormal phenomenon in which the extent of fibrous connective tissues is increased. In PKD, increases in the activity of molecules such as growth factor and TGF-β have been reported to occur and promote fibrosis. Therefore, the inflammation and fibrosis responses have been suggested as therapeutic targets for PKD. In order to guide further studies, this review indicates the roles of inflammatory and fibrosis signaling in PKD.


Inflammation Fibrosis Polycystic kidney disease Macrophage TNF-alpha TGF-beta 


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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.Molecular Medicine Laboratory, Department of Life systemsSookmyung Women’s UniversitySeoulSouth Korea
  2. 2.Department of Life systemsSookmyung Women’s UniversitySeoulSouth Korea

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