Abstract
Bioprocess technology/engineering deals with the development and applications of competent strains of microorganisms for their optimum metabolite production in a specialized bioreactor, depending on the growth kinetics and nature of metabolite production at their suitable physicochemical and nutritional levels. However, three important components are taken under consideration involving several microbiological and biochemical engineering skills, also known as biomolecular engineering along with architecture and design of bioreactor systems, because the design and architecture of a bioreactor is solely based on the nature of the microorganisms, growth, and metabolite production along with the elimination of toxic substances during fermentation. In the current scenario, the development of bioreactor technology can change any process parameters economically with greater productivity and quality of microbial products, therefore, the design and architecture of a bioreactor is important, and can make a new revolution in bioprocess engineering. The mutational and recombinant DNA technology has developed several beneficial microorganisms, and their large-scale economical production requires fermentation technology mainly in the development of suitable bioreactor systems and process parameters. Much work has been done by microbiologists and biochemists for the production of various microbial metabolites including enzymes, hormones, polysaccharides, organic acids, vitamins, and so on at laboratory scale through flask culture experiments, whereas commercial-scale production requires several correction factors as well as a specialized bioreactor for continuous production of microbial metabolites with minimum energy consumption. The importance of bioreactor systems and their evaluation for the architecture requires optimization of fermentation parameters by a benchtop fermentor, and then a bioreactor should be fabricated on the guidelines of the microbiologist adopting the corrective measures of several growth parameters for the optimum production of microbial metabolites.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bailey JE (1998) Mathematical modeling and analysis in biochemical engineering: past accomplishment and future opportunities. Biotechnol Prog 14:8
Blanch HW, Clark DS (1996) Biochemical engineering. Marcel Dekker, New York
Bloch HP, Soares C (2007) Mixers and agitators. In: Process plant machinery, 2nd edn. Butterworth-Heinemann, Boston, pp 617–631
Bohmer U, Suhardi SH, Bley T (2006) Decolorizing reactive textile dyes with white-rot fungi by temporary immersion cultivation. Eng Life Sci 6:417–420
Bronzino JD (2000) Editor in chief. The biomedical engineering handbook, 2nd edn. CRC press LLC, Boca Raton
Castilho LR, Polato CMS, Baruque EA et al (2000) Economic analysis of lipase production by Penicilliumrestrictum in solid-state and submerged fermentations. Biochem Eng J 4:239–247
Dominguez A, Rivela I, RodrÃguez Couto S et al (2001) Design of a new rotating drum bioreactor for ligninolytic enzyme production by Phanerochaetechrysosporium grown on an inert support. Process Biochem 37:549–554
Flickinger MC, Drew SW (1999) Encyclopedia of bioprocess technology: fermentation, biocatalysis and bioseperation. Wiley, New York
Font X, Caminal G, Gabarrell X et al (2003) Black liquor detoxification by laccase of Trametesversicolor pellets. J Chem Technol Biotechnol 78:548–554
Freitas C, Fialov M, Zahradnik J et al (2000) Hydrodynamics of a three-phase external-loop airlift bioreactor. J Chem Eng Sci 55:4961–4972
Galhaup C, Wagner H, Hinterstoisser B et al (2002) Increased production of laccase by the wood-degrading basidiomycete Trametespubescens. Enzym Microb Technol 30:529–536
Hammer MJ, Hammer MJJR (2001) Water and waste water technology, 4th edn. Prentice hall, Upper Saddle River
Kargi F, Moo-young M (1985) Transport phenomena in bioprocess. In: Moo-young M (ed) Comprehensive biotechnology, vol 2. Pergamon press, Oxford, pp 5–55
Kossen NWF (1985) Problems in the design of large scale bioreactors. In: Ghose TK (ed) Biotechnology and bioprocess engineering. Unit India Press, New Delhi, pp 365–385
Lee SY, Papoutsakis ET (1999) Metabolic engineering. Marcel dekker, New York
Mercille S, Johnson M, Louthier S et al (2000) Understanding factors that limit the productivity of suspension- based perfusion cultures operated at high medium renewal rates. Biotechnol Bioeng 67:435–450
Midgett RE (1986) Solid state fermentation. In: Demain AL, Solomon N (eds) A manual of industrial microbiology and technology. American Society for Microbiology, Washington, DC, pp 66–83
Moo-Young M, Moreira AR, Tengerdy RP (1983) Principles of solid sate fermentation. In: Smith JE, Berry DR, Kristiansen B (eds) The filamentous fungi. Edward Arnold Publishers, London, pp 117–144
Naughton GK (1999) Skin: the first tissue engineered products. The advanced tissue science story. Sci Am 4:8485
Pérez-Guerra N, Torrado-Agrasar A, Lopez-Macias C et al (2003) Main characteristics and applications of solid substrate fermentation. Electron J Environ Agric Food Chem 2:343–350
Rejsman HB (1993) Problems in scale up of biotechnology production processes. Crit Rev Biotechnol 13:195–253
Rivela I, RodrÃguez Couto S, Sanroman A (2000) Extracellular ligninolytic enzymes production by Phanerochaetechrysosporium in a new solid-state bioreactor. Biotechnol Lett 22:1443–1447
Rodriguez Couto S, Moldes D, Liebanas A et al (2003) Investigation of several bioreactor configurations for laccase production by Trametesversicolor operating in solid-state conditions. Biochem Eng J 15:21–26
Rodriguez Couto S, Lopez E, Sanroman MA (2006) Utilisation of grape seeds for laccase production in solid-state fermentors. J Food Eng 74:263–267
Rosales E, Rodriguez Couto, Sanroman MA (2007) Increased laccase production by Trameteshirsuta grown on crushed orange peelings. Enzym Microb Technol 40:1286–1290
Shuler ML (1985) On the use of chemically structured models for bioreactor. Chem Eng Commun 36:161–189
Shuler Michael L, Kargi F (2002) Bioprocess engineering basic concepts, 2nd edn. Prentice-Hall, New York
Singh R, Gaur R, Jamal F et al (2011) A novel fermentor system optimized for continuousproduction of pullulan. Afr J Biotechnol 10:9839–9846
Tavares APM, Coelho MAZ, Agapito MSM et al (2006) Optimization and modeling of laccase production by Trametesversicolor in a bioreactor using statistical experimental design. Appl Biochem Biotechnol 134:233–248
Viniegra-Gonzalez G, Favela-Torres E, Noe Aguilar C et al (2003) Advantages of fungal enzyme production in solid state over liquid fermentation systems. Biochem Eng J 13:157–167
Suggested Further Readings
Marques BC (2005) Aprimoramento de abordagem para modelar o balanço de agua embiorreactores de fermentaçaoem estado solido. Universidade Federal do Parana (1)
Rodriguez Couto S, Sanroman MA (2005) Application of solid-state fermentation to ligninolytic enzyme production. Biochem Eng J 22:211–219
RodrÃguez Couto S, Rosales E, Sanromán MA (2006) Decolourization of synthetic dyes by Trameteshirsuta in expanded-bed reactors. Chemosphere 62:1558–1563
Singhania RR, Patel AK, Soccolc CR et al (2009) Recent advances in solid-state fermentation. Biochem Eng J 44:13–18
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media Singapore
About this chapter
Cite this chapter
Gaur, R., Singh, A., Tripathi, A., Singh, R. (2017). Bioreactors. In: Singh, R. (eds) Principles and Applications of Environmental Biotechnology for a Sustainable Future. Applied Environmental Science and Engineering for a Sustainable Future. Springer, Singapore. https://doi.org/10.1007/978-981-10-1866-4_7
Download citation
DOI: https://doi.org/10.1007/978-981-10-1866-4_7
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-1865-7
Online ISBN: 978-981-10-1866-4
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)