Abstract
Rapid advancements in micro- and nanotechnologies have paved the way for the development of cell-/molecule-based biosensors at the micro/nano scale by providing novel micro/nano transducers and the integration of them with cells/molecules. In the recent decades, the integration of cells/molecules with micro/nano devices for the development of novel sensors with unique functions has attracted intensive interest and substantial research efforts. Exciting progress has been achieved due to the combination of micro/nano fabrication technologies with biotechnologies, which introduced new concepts and scientific paradigms to this area. Fast advancements in micro/nano structured devices are providing unprecedented opportunities to couple the devices with functional cells/molecules for the development of next generation of cell and molecular sensors. Micro/nano devices with novel designs at the micro/nano scale make it possible to integrate functional cells/molecules onto transducers with high efficiency and a negligible loss of functionality, which can improve the performances of sensors for the detection of responsive signals. Micro/nano cell and molecular sensors have become increasingly important and have found wide applications in a variety of areas. The topics covered by this book provide a comprehensive summary of the current state of micro/nano cell and molecular sensors as well as their future trend of development, which will be of great interest to the interdisciplinary research community active in this area. In this chapter, we will introduce the definition, characteristics, and types of micro/nano cell and molecular sensors.
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Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell. 1991;65(1):175–87.
Nakamura T. Cellular and molecular constituents of olfactory sensation in vertebrates. Comp Biochem Physiol A Mol Integr Physiol. 2000;126(1):17–32.
Ache BW, Young JM. Olfaction: diverse species, conserved principles. Neuron. 2005;48(3):417–30.
Gilbertson TA, Boughter JD, Zhang H, Smith DV. Distribution of gustatory sensitivities in rat taste cells: whole-cell responses to apical chemical stimulation. J Neurosci. 2001;21(13):4931–41.
DeFazio RA, Dvoryanchikov G, Maruyama Y, Kim JW, Pereira E, Roper SD, Chaudhari N. Separate populations of receptor cells and presynaptic cells in mouse taste buds. J Neurosci. 2006;26(15):3971–80.
Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS. The receptors and cells for mammalian taste. Nature. 2006;444(7117):288–94.
Wu C, Wang L, Zhou J, Zhao L, Wang P. The progress of olfactory transduction and biomimetic olfactory-based biosensors. Chin Sci Bull. 2007;52(14):1886–96.
Du L, Zou L, Zhao L, Wang P, Wu C. Biomimetic chemical sensors using bioengineered olfactory and taste cells. Bioengineered. 2014;5(5):326–30.
Wu C, Du L, Zou L, Zhao L, Huang L, Wang P. Recent advances in taste cell-and receptor-based biosensors. Sensors Actuators B. 2014;201:75–85.
Prasad S, Tuncel E, Ozkan M. Association of different prediction methods for determination of the efficiency and selectivity on neuron-based sensors. Biosens Bioelectron. 2006;21(7):1045–58.
Morin F, Nishimura N, Griscom L, LePioufle B, Fujita H, Takamura Y, Tamiya E. Constraining the connectivity of neuronal networks cultured on microelectrode arrays with microfluidic techniques: a step towards neuron-based functional chips. Biosens Bioelectron. 2006;21(7):1093–100.
Wang T, Hu N, Cao J, Wu J, Su K, Wang P. A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating. Biosens Bioelectron. 2013;49:9–13.
Liu Q, Cai H, Xu Y, Xiao L, Yang M, Wang P. Detection of heavy metal toxicity using cardiac cell-based biosensor. Biosens Bioelectron. 2007;22(12):3224–9.
DeBusschere BD, Kovacs GT. Portable cell-based biosensor system using integrated CMOS cell-cartridges. Biosens Bioelectron. 2001;16(7):543–56.
Du L, Wu C, Liu Q, Huang L, Wang P. Recent advances in olfactory receptor-basedbiosensors. Biosens Bioelectron. 2013;42:570–80.
Sassolas A, Leca-Bouvier BD, Blum LJ. DNA biosensors and microarrays. Chem Rev. 2008;108(1):109–39.
Liu A, Wang K, Weng S, Lei Y, Lin L, Chen W, Lin X, Chen Y. Development of electrochemical DNA biosensors. TrAC Trends Anal Chem. 2012;37:101–11.
Ho C-M, Tai Y-C. Micro-electro-mechanical-systems (MEMS) and fluid flows. Annu Rev Fluid Mech. 1998;30(1):579–612.
Grayson ACR, Shawgo RS, Johnson AM, Flynn NT, Li Y, Cima MJ, Langer R. A BioMEMS review: MEMS technology for physiologically integrated devices. Proc IEEE. 2004;92(1):6–21.
Bashir R. BioMEMS: state-of-the-art in detection, opportunities and prospects. Adv Drug Deliv Rev. 2004;56(11):1565–86.
Turner A, Karube I, Wilson GS. Biosensors: fundamentals and applications. 1987.
Liu Q. Cell-based biosensors: principles and applications (Artech House, 2014). 2014.
Wang P, Liu Q, Xu Y, Cai H, Li Y. Olfactory and taste cell sensor and its applications in biomedicine. Sensors Actuators A Phys. 2007;139(1):131–8.
Wu C, Chen P, Yu H, Liu Q, Zong X, Cai H, Wang P. A novel biomimetic olfactory-based biosensor for single olfactory sensory neuron monitoring. Biosens Bioelectron. 2009;24(5):1498–502.
Wu C, Du L, Mao L, Wang P. A novel bitter detection biosensor based on light addressable potentiometric sensor. J Innov Opt Health Sci. 2012;5(02):1250008.
Kim D-S, Jeong Y-T, Park H-J, Shin J-K, Choi P, Lee J-H, Lim G. An FET-type charge sensor for highly sensitive detection of DNA sequence. Biosens Bioelectron. 2004;20(1):69–74.
Kataoka-Hamai C, Miyahara Y. Label-free detection of DNA by field-effect devices. Sensors J IEEE. 2011;11(12):3153–60.
Wu C, Bronder T, Poghossian A, Werner CF, Schöning MJ. Label-free detection of DNA using a light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer. Nanoscale. 2015;7(14):6143–50.
Chaniotakis N, Sofikiti N. Novel semiconductor materials for the development of chemical sensors and biosensors: a review. Anal Chim Acta. 2008;615(1):1–9.
Zeck G, Fromherz P. Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip. Proc Natl Acad Sci. 2001;98(18):10457–62.
Kotov NA, Winter JO, Clements IP, Jan E, Timko BP, Campidelli S, Pathak S, Mazzatenta A, Lieber CM, Prato M. Nanomaterials for neural interfaces. Adv Mater. 2009;21(40):3970–4004.
Stenlund P, Babcock GJ, Sodroski J, Myszka DG. Capture and reconstitution of G protein-coupled receptors on a biosensor surface. Anal Biochem. 2003;316(2):243–50.
Xiao L, Liu Q, Hu Z, Zhang W, Yu H, Wang P. A multi-scale electrode array (MSEA) to study excitation–contraction coupling of cardiomyocytes for high-throughput bioassays. Sensors Actuators B. 2011;152(1):107–14.
Xiao L, Hu Z, Zhang W, Wu C, Yu H, Wang P. Evaluation of doxorubicin toxicity on cardiomyocytes using a dual functional extracellular biochip. Biosens Bioelectron. 2010;26(4):1493–9.
Liu Q, Wu C, Cai H, Hu N, Zhou J, Wang P. Cell-based biosensors and their application in biomedicine. Chem Rev. 2014;114(12):6423–61.
Wu C, Lillehoj PB, Wang P. Bioanalytical and chemical sensors using living taste, olfactory, and neural cells and tissues: a short review. Analyst. 2015;140(21):7048–61.
Duan X, Gao R, Xie P, Cohen-Karni T, Qing Q, Choe HS, Tian B, Jiang X, Lieber CM. Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor. Nat Nanotechnol. 2012;7(3):174–9.
Gui EL, Li L-J, Zhang K, Xu Y, Dong X, Ho X, Lee PS, Kasim J, Shen Z, Rogers JA. DNA sensing by field-effect transistors based on networks of carbon nanotubes. J Am Chem Soc. 2007;129(46):14427–32.
Nguyen TA, Yin T-I, Reyes D, Urban GA. Microfluidic chip with integrated electrical cell-impedance sensing for monitoring single cancer cell migration in three-dimensional matrixes. Anal Chem. 2013;85(22):11068–76.
Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS. Screening drug-induced arrhythmia using human induced pluripotent stem cell–derived cardiomyocytes and Low-impedance microelectrode arrays. Circulation. 2013;128(11 suppl 1):S3–13.
Hu N, Fang J, Li H, Su K, Wang P. Dual-function microelectrode array system for simultaneously monitoring electromechanical integration status of cardiomyocytes, in Editor (Ed.)^(Eds.): Book dual-function microelectrode array system for simultaneously monitoring electromechanical integration status of cardiomyocytes (IEEE, 2015, edn.), p. 1519–22.
Qing Q, Pal SK, Tian B, Duan X, Timko BP, Cohen-Karni T, Murthy VN, Lieber CM. Nanowire transistor arrays for mapping neural circuits in acute brain slices. Proc Natl Acad Sci. 2010;107(5):1882–7.
Yang W, Ratinac KR, Ringer SP, Thordarson P, Gooding JJ, Braet F. Carbon nanomaterials in biosensors: should you use nanotubes or graphene? Angew Chem Int Ed. 2010;49(12):2114–38.
Pandey P, Datta M, Malhotra B. Prospects of nanomaterials in biosensors. Anal Lett. 2008;41(2):159–209.
Wang J. Nanomaterial-based electrochemical biosensors. Analyst. 2005;130(4):421–6.
Patolsky F, Weizmann Y, Willner I. Long‐range electrical contacting of redox enzymes by SWCNT connectors. Angew Chem Int Ed. 2004;43(16):2113–7.
Welz B, Sperling M. Atomic absorption spectrometry. Weinheim: Wiley; 2008.
Jarvis KE, Gray AL, Houk RS. Handbook of inductively coupled plasma mass spectrometry. New York: Blackie; Chapman and Hall; 1991.
Schöning MJ, Kloock JP. About 20 years of silicon – based thin – film sensors with chalcogenide glass materials for heavy metal analysis: technological aspects of fabrication and miniaturization. Electroanalysis. 2007;19(19‐20):2029–38.
Wan H, Ha D, Zhang W, Zhao H, Wang X, Sun Q, Wang P. Design of a novel hybrid sensor with microelectrode array and LAPS for heavy metal determination using multivariate nonlinear calibration. Sensors Actuators B. 2014;192:755–61.
Ha D, Hu N, Wu C, Kirsanov D, Legin A, Khaydukova M, Wang P. Novel structured light-addressable potentiometric sensor array based on PVC membrane for determination of heavy metals. Sensors Actuators B. 2012;174:59–64.
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Wang, P., Wu, C., Hu, N., Hsia, K.J. (2016). Introduction. In: Wang, P., Wu, C., Hu, N., Hsia, K. (eds) Micro/Nano Cell and Molecular Sensors. Springer, Singapore. https://doi.org/10.1007/978-981-10-1658-5_1
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DOI: https://doi.org/10.1007/978-981-10-1658-5_1
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