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Medical Imaging Informatics

  • William Hsu
  • Suzie El-Saden
  • Ricky K. Taira
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 939)

Abstract

Imaging is one of the most important sources of clinically observable evidence that provides broad coverage, can provide insight on low-level scale properties, is noninvasive, has few side effects, and can be performed frequently. Thus, imaging data provides a viable observable that can facilitate the instantiation of a theoretical understanding of a disease for a particular patient context by connecting imaging findings to other biologic parameters in the model (e.g., genetic, molecular, symptoms, and patient survival). These connections can help inform their possible states and/or provide further coherent evidence. The field of radiomics is particularly dedicated to this task and seeks to extract quantifiable measures wherever possible. Example properties of investigation include genotype characterization, histopathology parameters, metabolite concentrations, vascular proliferation, necrosis, cellularity, and oxygenation. Important issues within the field include: signal calibration, spatial calibration, preprocessing methods (e.g., noise suppression, motion correction, and field bias correction), segmentation of target anatomic/pathologic entities, extraction of computed features, and inferencing methods connecting imaging features to biological states.

Keywords

Radiomics Radiogenomics Magnetic resonance imaging Glioblastoma multiforme Quantitative imaging Imaging standards Imaging informatics 

Notes

Acknowledgments

The authors would like to thank the following medical imaging informatics doctoral students for their valuable intellectual contributions to this chapter: Nova Smedley, Nicholas J. Matiasz, Edgar Rios Piedra, and King Chung (Johnny) Ho. We would also like to thank Lew Andrada for his proofreading and general editing services.

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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  1. 1.Department of Radiological SciencesUniversity of CaliforniaLos AngelesUSA

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