Abstract
There is large unexplored world inside us which is complicated and interesting. Just a half-century ago, very little was known about the genetic factors that contribute to human diseases. In 1953, James Watson and Francis Crick described the double helix structure of deoxyribonucleic acid (DNA), the chemical compound that contains the genetic instructions for building, running, and maintaining living organisms. Methods to determine the order, or sequence, of the chemical letters in DNA were developed in the mid-1970s along with the advancement in technology of microscopy, molecular biology, and genetic engineering, because of which it was becoming possible to conduct a serious and systemic exploration of our internal world.
Each cell present in the body has two near identical chromosomes sets. The DNA is packaged in a tight but sophisticated manner in these chromosomes. Deciphering the order of every DNA base on each chromosome in a genome is genome sequence. A genome map identifies the landmarks, which help in navigating around the genome. In this chapter, the readers would understand the principles of human genome project, genome projects of model organisms, genomics of pathogens, and evolution of influenza, hepatitis B, and HIV genome.
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Some Related websites
Some Related Resources
Council for Responsible Genetics
Department of Energy (DOE) Human Genome Project Information
Ensembl Human Genome Browser
ESRC Centre for Genomics in Society (Egenis), University of Exeter
Human Genome News (DOE/NHGRI publication)
Human Genome Organization (HUGO)
HumGen International (ELSI resources)
National Center for Biotechnology Information (NCBI) Human Genome Resources
National Human Genome Research Institute (NHGRI) All About the Human Genome Project (HGP)
Nature Human Genome Collection
NHGRI ELSI Research Program
Nuffield Council on Bioethics
Science Human Genome Special Issue 16 February 2001
Wellcome Trust Sanger Institute Human Genome Project
World Health Organization Genomic Resource Centre
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Gupta, V., Sengupta, M., Prakash, J., Tripathy, B.C. (2017). Genome Sequencing. In: Basic and Applied Aspects of Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-0875-7_6
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DOI: https://doi.org/10.1007/978-981-10-0875-7_6
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