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Fundamentals of Physical Pharmacy: The Biophysics of Nanosystems

  • Costas Demetzos
Chapter

Abstract

The principles of physical sciences and the application of physical laws in the field of medicines and in pharmaceutical sciences are considered as effective tools in order to develop nanotechnological products. Biomolecules and biomaterials that are the building blocks of nanosystems and their similarity with the structural elements of the human cell are important factors for the understanding of the physicochemical behavior of nanosystems. Biophysics and thermodynamics of cell membranes reflect to the behavior of nanoparticulate systems that are able to deliver bioactive molecules to the target tissues. The liquid crystalline state of nanosystems leads their behavior, while their thermotropic properties can provide information regarding their physicochemical profile and consequently their therapeutic effectiveness. Their stability is considered as a crucial issue, and DLVO theory efficiently explains their behavior and provides evidence that corresponds to their behavior in in vitro media and in vivo experiments. Thermal analysis is also a useful technique that is used to measure thermodynamic parameter that project to their thermotropic behavior. Freeze-drying process is an extensive studied technique that applied in dispersed systems to secure their lifelong physicochemical stability.

Keywords

Physical pharmacy Biophysics Thermal analysis Microscopy DLVO theory Stability 

References

  1. 1.
    Attwood D, Florence (2012) Physical pharmacy PhP. Royal Pharmaceutical Society, OxfordGoogle Scholar
  2. 2.
    Bangham AD, Standish MM, Watkins JC (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 13:238–252CrossRefPubMedGoogle Scholar
  3. 3.
    Chapman D (1975) Phase transitions and fluidity characteristics of lipids and membranes. Quart Rev Biophys 8:185–235CrossRefGoogle Scholar
  4. 4.
    Delgadro AV, Conzalez-Caballero F, Hunter RH et al (2007) Measurements and interactions of electrokinetic phenomena. J Control Interface Sci 309:194–224CrossRefGoogle Scholar
  5. 5.
    Demetzos C (2008) Differential Scanning Calorimetry (DSC): a tool to study the thermal behavior of lipid bilayers and liposomal stability. J Liposomes Res 18:159–173CrossRefGoogle Scholar
  6. 6.
    Derjaguin BV, Landau LD (1941) Theory of the stability of strongly charged lyophobic sols and of adhesion of strongly charged particles in solution of electrolytes. Acta Physicochim URRS 14:633–662Google Scholar
  7. 7.
    Evans WH (1980) A biochemical dissection of the functional polarity of the plasma membrane of hepatocyte. Biochim Biophys Acta 604:27–64CrossRefPubMedGoogle Scholar
  8. 8.
    Evans WH (1979) Preparation and characterization of mammalian plasma membranes. In: Work TS, Work E (eds) Laboratory techniques in biochemistry and molecular biology part I. North-Holland, AmsterdamGoogle Scholar
  9. 9.
    Florence AT, Attwood D (1988) Physicochemical principles of pharmacy. Macmillan, LondonCrossRefGoogle Scholar
  10. 10.
    Heimburg T (2007) Thermal biophysics of membranes. Wiley-VCH, WeinheimCrossRefGoogle Scholar
  11. 11.
    Heurtault B, Saulnier P, Pech B, Proust JE et al (2003) Physico-chemical stability of colloidal lipid particles. Biomaterials 24:4283–4300CrossRefPubMedGoogle Scholar
  12. 12.
    Kewal KJ (2008) The handbook of nanomedicine. Humana Press, Basel, pp 14–21Google Scholar
  13. 13.
    Koutsoulas C, Pippa N, Demetzos C et al (2012) The role of ζ-potential on the stability of nanocolloidal systems. Pharmakeftiki 24:106–111Google Scholar
  14. 14.
    Lasic DD (1993) Liposomes: from physics to applications. Elsevier Publishing Company, AmsterdamGoogle Scholar
  15. 15.
    Lasic DD, Papahadjopoulos D (eds) (1998) Medical applications of liposomes. Elsevier, AmsterdamGoogle Scholar
  16. 16.
    Lee AG (1977) Liquid phase transitions and phase diagrams: I lipid phase transitions. Biochim Biophys Acta 472:237–281CrossRefPubMedGoogle Scholar
  17. 17.
    Mazzola L (2003) Commercializing nanotechnology. Nat Biotechnol 21:1137–1142CrossRefPubMedGoogle Scholar
  18. 18.
    Mishra B, Bhavesh B, Tiwari S (2010) Colloidal nanocarriers: a review on formulation technology, types and applications towards targeted drug delivery. Nanomedicine 6:9–24PubMedGoogle Scholar
  19. 19.
    Nodre W (2003) Colloids and interfaces in life science. Marcel Dekker, New YorkGoogle Scholar
  20. 20.
    Okhi S, Ohsihima H (1999) Interaction and aggregation of lipid vesicles (DLVO theory versus modified DLVO theory). Colloids Surf B: Biointerfaces 14:27–45CrossRefGoogle Scholar
  21. 21.
    Papahadjopoulos D, Bangham AD (1966) Biophysical properties of phospholipids II permeability of phosphatidylserine liquid crystals to univalent ions. Biochim Biophys Acta 126:185–188CrossRefPubMedGoogle Scholar
  22. 22.
    Spyratou E, Mourelatou E, Makropoulou M et al (2009) Atomic force microscopy: a tool to study the structure, dynamics and stability of liposomal drug delivery systems. Exp Opin Drug Deliv 6(3):305–317CrossRefGoogle Scholar
  23. 23.
    Verwey EJB, Overbeek JTG (1948) Theory of the stability of lyophobic colloids. Elsevier, AmsterdamGoogle Scholar
  24. 24.
    Wagner V, Dullaart A, Bock AK, Zweck A (2006) The emerging nanomedicine landscape. Nat Biotechnol 24:1211–1217CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Costas Demetzos
    • 1
  1. 1.Faculty of PharmacyNational & Kapodistrian University of AthensZografouGreece

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