Fundamentals of Physical Pharmacy: The Biophysics of Nanosystems

  • Costas Demetzos


The principles of physical sciences and the application of physical laws in the field of medicines and in pharmaceutical sciences are considered as effective tools in order to develop nanotechnological products. Biomolecules and biomaterials that are the building blocks of nanosystems and their similarity with the structural elements of the human cell are important factors for the understanding of the physicochemical behavior of nanosystems. Biophysics and thermodynamics of cell membranes reflect to the behavior of nanoparticulate systems that are able to deliver bioactive molecules to the target tissues. The liquid crystalline state of nanosystems leads their behavior, while their thermotropic properties can provide information regarding their physicochemical profile and consequently their therapeutic effectiveness. Their stability is considered as a crucial issue, and DLVO theory efficiently explains their behavior and provides evidence that corresponds to their behavior in in vitro media and in vivo experiments. Thermal analysis is also a useful technique that is used to measure thermodynamic parameter that project to their thermotropic behavior. Freeze-drying process is an extensive studied technique that applied in dispersed systems to secure their lifelong physicochemical stability.


Physical pharmacy Biophysics Thermal analysis Microscopy DLVO theory Stability 


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Copyright information

© Springer Science+Business Media Singapore 2016

Authors and Affiliations

  • Costas Demetzos
    • 1
  1. 1.Faculty of PharmacyNational & Kapodistrian University of AthensZografouGreece

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