Abstract
Soft tissue sarcoma is an extremely rare disease with an annual incidence of 3 per 100,000 people, accounting for 1 % or less of all malignant tumors. High-grade soft tissue sarcoma requires multidisciplinary therapy including chemotherapy, surgery, and radiotherapy, though surgery remains the primary therapy. Nowadays more than 90 % of patients undergo surgery preserving the affected limb. However, postoperative local recurrence and loss of function after wide excision remains a concern. We have performed radio-hyperthermo-chemotherapy (RHC) for patients with high-grade soft tissue sarcoma with the goal of improving local control, reducing the resection margin, improving postoperative function, and controlling distant metastasis by improving chemotherapy sensitivity. In this chapter, we first reviewed the previous reports of hyperthermia for soft tissue sarcomas, and discuss our treatment protocol and treatment outcomes.
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Hattori M. Effect of hyperthermia on cultured malignant musculoskeletal tumor cells. Nagoya Med J. 1993;37:135–50.
Yonezawa M, Otsuka T, Matsui N, Tsuji H, Kato KH, Moriyama A, Kato T. Hyperthermia induces apoptosis in malignant fibrous histiocytoma cells in vitro. Int J Cancer. 1996;66:347–51.
Tsuji H. Experimental study of radio-hyperthermia for the malignant fibrous histiocytoma in vivo. The Journal of the Nagoya City University Medical Association. 2002;53:77–85 (Japanese).
Kal HB, Hahn GM. Kinetic responses of murine sarcoma cells to radiation and hyperthermia in vivo and in vitro. Cancer Res. 1976;36:1923–9.
Westermann AM, Wiedemann GJ, Jager E, Jager D, Katschinski DM, Knuth A, Vörde Sive Vörding PZ, Van Dijk JD, Finet J, Neumann A, Longo W, Bakhshandeh A, Tiggelaar CL, Gillis W, Bailey H, Peters SO, Robins HI; Systemic Hyperthermia Oncologic Working Group. Oncology.A systemic hyperthermia oncologic working group trial. Ifosfamide, carboplatin, and etoposide combined with 41.8 degrees C whole-body hyperthermia for metastatic soft tissue sarcoma. 2003;64:312–321.
Lehti PM, Moseley HS, Janoff K, Stevens K, Fletcher WS. Improved survival for soft tissue sarcoma of the extremities by regional hyperthermic perfusion, local excision and radiation therapy. Surg Gynecol Obstet. 1986;162:149–52.
Hill S, Fawcett WJ, Sheldon J, Soni N, Williams T, Thomas JM. Low-dose tumour necrosis factor alpha and melphalan in hyperthermic isolated limb perfusion. Br J Surg. 1993;80:995–7.
Grunhagen DJ, de Wilt JH, Graveland WJ, Verhoef C, van Geel AN, Eggermont AM. Outcome and prognostic factor analysis of 217 consecutive isolated limb perfusions with tumor necrosis factor-alpha and melphalan for limb-threatening soft tissue sarcoma. Cancer. 2006;106:1776–84.
Issels RD, Abdel-Rahman S, Wendtner C, Falk MH, Kurze V, Sauer H, Aydemir U, Hiddemann W. Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study. Eur J Cancer. 2001;37:1599–608.
Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, Abdel-Rahman S, Daugaard S, Salat C, Wendtner CM, Vujaskovic Z, Wessalowski R, Jauch KW, Dürr HR, Ploner F, Baur-Melnyk A, Mansmann U, Hiddemann W, Blay JY, Hohenberger P; European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC-STBSG); European Society for Hyperthermic Oncology (ESHO). Neo-adjuvant chemotherapy alone or with regional hyperthermia for localized high-risk soft-tissue sarcoma: a randomized phase 3 multicenter study. Lancet Oncol. 2010;11:561–570.
Willett CG, Schiller AL, Suit HD, Mankin HJ, Rosenberg A. The histologic response of soft tissue sarcoma to radiation therapy. Cancer. 1987;60:1500–4.
Hayashi K, Yamada S, Inatani H, Okamoto H, Takeuchi A, Nishida H, Yamamoto N, Tsuchiya H, Otsuka T. Salvage method for unplanned excision of soft tissue sarcoma: long-term results of second-look surgery following radio-hyperthermo-chemotherapy. Anticancer Res. 2015;35:493–8.
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© 2016 Springer Science+Business Media Singapore
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Aiba, H., Kimura, H., Otsuka, T. (2016). Combination by Hyperthermia and Radiation and Chemotherapy: Soft Tissue Sarcoma. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_21
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DOI: https://doi.org/10.1007/978-981-10-0719-4_21
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