Abstract
Parvalbumin-deficient mice (PVKO) are characterized by changes in the dynamics of firing activity in the thalamocortical circuit but their ability to learn instrumental conditioning was not yet assessed. This study reports that PVKO mice are ultimately able to learn an operant behavioral task and reach a level of performance similar to wild-type (WT) mice, although with a delayed and altered dynamics of learning. We have performed multisite recordings and analyzed multiunit activity in the basal ganglia–thalamocortical circuit and we observed a decreased oscillatory activity, as well as less synchronized activity between nucleus accumbens (NAc) and the prefrontal cortex of PVKO while the mice were freely roaming.
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Acknowledgments
We wish to thank B. Schwaller for his advice and providing the PVKO animals, J.M. González Martín, M. Sánchez Enciso, R. Sánchez-Campusano and J.A. Santos Naharro for technical assistance and A.E.P. Villa for his advice on spike sorting.
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Gruart, A., Delgado-García, J.M., Lintas, A. (2016). Effect of Parvalbumin Deficiency on Distributed Activity and Interactions in Neural Circuits Activated by Instrumental Learning. In: Wang, R., Pan, X. (eds) Advances in Cognitive Neurodynamics (V). Advances in Cognitive Neurodynamics. Springer, Singapore. https://doi.org/10.1007/978-981-10-0207-6_17
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DOI: https://doi.org/10.1007/978-981-10-0207-6_17
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