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Multifunctional Hollow Mesoporous Silica Nanoparticles for MR/US Imaging-Guided Tumor Therapy

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Advances in Nanotheranostics II

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 7))

Abstract

Biocompatible mesoporous silica nanoparticles and their multifunctionalization have attracted ever-increasing attentions in the biomedical research fields recently. In this chapter, we particularly focus on the controlled fabrication of hollow mesoporous silica nanoparticles (HMSNs) for their applications in magnetic resonance imaging (MRI), ultrasonography (US), and MRI/US-guided cancer synergistic therapy. The content of this chapter includes: (1) design, synthesis, surface modification and multifunctionalization of HMSNs with high dispersity and desirable crucial structural/compositional parameters, (2) HMSNs as the contrast agents (CAs) for MR imaging, (3) HMSN-based nanocomposites for US imaging, and (4) HMSN-based nanosystems for high-intensity focused ultrasound (HIFU) synergistic therapy. The unsolved critical issues and future developments of HMSNs for clinical translation are also briefly outlooked.

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Authors and Affiliations

  1. Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295, Dingxi Road, Shanghai, 200050, China

    Yu Chen, Ming Ma, Hangrong Chen & Jianlin Shi

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  1. Yu Chen
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  2. Ming Ma
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Correspondence to Hangrong Chen .

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  1. College of Engineering, Peking University, Beijing, China

    Zhifei Dai

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Chen, Y., Ma, M., Chen, H., Shi, J. (2016). Multifunctional Hollow Mesoporous Silica Nanoparticles for MR/US Imaging-Guided Tumor Therapy. In: Dai, Z. (eds) Advances in Nanotheranostics II. Springer Series in Biomaterials Science and Engineering, vol 7. Springer, Singapore. https://doi.org/10.1007/978-981-10-0063-8_6

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