Abstract
Sleep loss leads to activation of the unfolded protein response (UPR) not only in the brain but also in peripheral organs (heart, lung, and pancreas). This has been shown in multiple species including mice, rats, Drosophila, and migratory birds. The unfolded protein response to sleep loss changes with age. In older mice, there is activation of the maladaptive response to sleep loss with increased expression of genes in the pro-apoptotic pathway. UPR is not simply a consequence of sleep loss but also affects sleep behavior. Alteration of the molecular machinery of the UPR alters baseline sleep as well as the degree of sleep recovery following sleep deprivation. Moreover, administration of drugs that alter the UPR can reduce the sleep fragmentation that occurs with age. UPR response to sleep loss has implications for neurodegenerative disorders and other medical conditions.
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Acknowledgments
Thanks to Sarah Ly for helpful comments and edits during the writing of the manuscript and Michael Paolini for assistance with figures. This study was supported by NIH/AG17628.
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Naidoo, N. (2022). Sleep Loss and the Unfolded Protein Response. In: Pack, A.I., Li, Q.Y. (eds) Sleep and its Disorders. Translational Medicine Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-2168-2_7
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