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Natural Products from Corals

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Symbiotic Microbiomes of Coral Reefs Sponges and Corals

Abstract

Cnidarians (mainly corals) are one of the most important resources of marine natural products (MNPs). Corals have rich species diversity, with more than 10 orders having 7000 species been found. The orders Alcyonacea (soft corals) and Gorgonacea (sea fans) which are referred to as ahermatypes, or non-reef building corals, have contributed with promising bioactive marine compounds. Till now, there have been more than 5800 compounds obtained from corals all over the world, attributing almost 20% of the total MNPs. These secondary metabolites are mostly representative as terpenoids and steroids. More than a hundred of the coral-derived natural products have great potential for the development of new pharmaceuticals and antifoulants. In this section, the research progress on coral-derived MNPs during the past two decades was included, mainly focusing on five points: (1) coral-produced structures with brand-new skeleton, (2) coral-derived MNPs with significant bioactivities, (3) some representative approaches on total synthesis of coral-derived novel compounds, (4) a short review of the coral-derived compounds in preclinical and clinical development, and (5) Conclusion.

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Authors and Affiliations

  1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People’s Republic of China

    Guoqiang Li, Pinglin Li & Xuli Tang

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  1. Marine Biotechnology Laboratory, State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

    Zhiyong Li

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Li, G., Li, P., Tang, X. (2019). Natural Products from Corals. In: Li, Z. (eds) Symbiotic Microbiomes of Coral Reefs Sponges and Corals. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1612-1_16

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