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Uncaria tomentosa (Willd. ex Schult.) DC. and Uncaria guianensis (Aubl.) J.F. Gmell

  • Izaskun UrdanibiaEmail author
  • Peter Taylor
Chapter
Part of the Medicinal and Aromatic Plants of the World book series (MAPW, volume 5)

Abstract

The jungles of Central and South America contain two predominant species of cat’s claw (Uña de Gato), Uncaria tomentosa (Willd. ex Schult.) DC. and Uncaria guianensis (Aubl.) J.F. Gmell, which are used in traditional medicine mainly for their anti-inflammatory properties. However, a wealth of compounds have been isolated from these two vines of the Rubiaceae family, including alkaloids, flavonoids and terpenoids, showing a wide range of activities: anti-inflammatory, anti-oxidative, hypotensor, antiviral, smooth muscle relaxant, antispasmodic, gastrointestinal mucosa protector, antiarrhythmic, anticonvulsant, analgesic, anti-leishmaniosis, cytostatic, cytotoxic, hypoglycaemizing, anticholestatic, antihistaminic, hepatoprotective, diuretic, antiulcer, immunostimulating and sedative effects. Some of these activities have been confirmed in both in vitro and in vivo models.

Keywords

Uncaria tomentosa Uncaria guianensis Cat’s claw Medicinal plant Peru Inflammation Cancer 

Abbreviations

POA

Pentacyclic Oxindole Alkaloids

TOA

Tetracyclic Oxindole Alkaloids

NF-κB

Nuclear Transcription Factor

TNF-α

Tumour Necrosis Factor alpha

IL-1

Interleukin-1

PGE2

Prostaglandin E2

NO

Nitric Oxide

COX-1

Cyclooxygenase-1

iNOS

inducible Nitric Oxygen Synthase

MAPK

Mitogen-Activated Protein Kinase

MMP

Matrix Metalloproteinases

VEGF

Vascular Endothelial Growth Factor

Notes

Acknowledgments

We would like to thank Ilsa Coronel for her help in the preparation of this manuscript.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Centre for Experimental MedicineVenezuelan Institute for Scientific Research (IVIC)CaracasVenezuela

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