Advertisement

Ptychopetalum olacoides Benth.

  • Leonardo Frasson dos Reis
  • Fúlvio Rieli Mendes
Chapter
Part of the Medicinal and Aromatic Plants of the World book series (MAPW, volume 5)

Abstract

The Ptychopetalum olacoides Benth. (Olacaceae) is an Amazonian tree popularly known as muirapuama or marapuama, among other names, which is used for several central nervous system related problems. The roots and occasionally the bark roots are the main medicinal parts employed and are prepared as an alcoholic infusion, tinctures, and tea. Phytochemical studies revealed that the roots contain tannins, flavonoids, and several terpenoids, while the presence of alkaloids is not clear. Most studies used ethanolic or hydroalcoholic extracts prepared with the roots of the plant. These studies indicate that the species has promising potential for treating central nervous system disorders, acting as an antidepressant, an anti-stress, a neuroprotective agent, and improving cognition. Although some herbal products contain P. olacoides in their composition, clinical studies are still needed to confirm the effects observed in pre-clinical studies.

Keywords

Ptychopetalum olacoides Olacaceae Muirapuama Neuroprotective Neurotonic Catuama 

Notes

Acknowledgements

The authors thank Prof. Wayne Losano for the grammar review.

References

  1. Anselmino E (1932) Die Stammpflanzen der droge Muira-puama. Notizblatt Königl Bot Gartens Mus Berl 11(107):623–629 GermanCrossRefGoogle Scholar
  2. Anselmino E (1933) Die Stammpflanzen von Muira-puama. Arch Pharm (Weinheim) 271(5):296–314 GermanCrossRefGoogle Scholar
  3. Antunes E, Gordo WM, de Oliveira JF, Teixeira CE, Hyslop S, De Nucci G (2001) The relaxation of isolated rabbit corpus cavernosum by the herbal medicine Catuama and its constituents. Phytother Res 15(5):416–421CrossRefGoogle Scholar
  4. Auterhoff H, Pankow E (1968) Inhaltsstoffe von Muira puama. Arch Pharm (Weinheim) 301(7):481–489 GermanCrossRefGoogle Scholar
  5. Bonnard M (1999) The Viagra alternative: the complete guide to overcoming erectile dysfunction naturally. Healing Arts Press, Rochester, p 226Google Scholar
  6. Braz R, Wolf LG, Lopes GC, Mello JCP (2012) Quality control and TLC profile data on selected plant species commonly found in the Brazilian market. Rev Bras Farmacog 22(5):1111–1117CrossRefGoogle Scholar
  7. Bucci LR (2000 Aug) Selected herbals and human exercise performance. Am J Clin Nutr 72(2 Suppl):624S–636SCrossRefGoogle Scholar
  8. Bucek EU, Fournier G, Dadoun H (1987) Volatile constituents of Ptychopetalum olacoides root oil. Planta Med 53(2):231CrossRefGoogle Scholar
  9. Calixto JB, Cabrini DA (1997) Herbal medicine Catuama induces endothelium-dependent and independent vasorelaxant action on isolated vessels from rats, Guinea-pigs and rabbits. Phytother Res 11(1):32–38CrossRefGoogle Scholar
  10. Campos MM, Fernandes ES, Ferreira J, Bortolanza LB, Santos ARS, Calixto JB (2004) Pharmacological and neurochemical evidence for antidepressant-like effects of the herbal product Catuama. Pharmacol Biochem Behav 78(4):757–764CrossRefGoogle Scholar
  11. Chalchat J-C, Garry R-P, Michet A, Benjilali B, Chabart JL (1993) Essential oils of Rosemary (Rosmarinus officinalis L.). The chemical composition of oils of various origins (Morocco, Spain, France). J Essent Oil Res 5(6):613–618CrossRefGoogle Scholar
  12. Da Silva AL, Bardini S, Nunes DS, Elisabetsky E (2002) Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama). Phytother Res 16(3):223–226CrossRefGoogle Scholar
  13. Da Silva AL, Piato ALS, Bardini S, Netto CA, Nunes DS, Elisabetsky E (2004) Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice. J Ethnopharmacol 95(2–3):199–203CrossRefGoogle Scholar
  14. Da Silva AL, Piato AL, Ferreira JG, Martins BS, Nunes DS, Elisabetsky E (2007) Promnesic effects of Ptychopetalum olacoides in aversive and non-aversive learning paradigms. J Ethnopharmacol 109(3):449–457CrossRefGoogle Scholar
  15. Da Silva AL, Ferreira JG, da Silva Martins B, Oliveira S, Mai N, Nunes DS et al (2008) Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama). Physiol Behav 95(1–2):88–92CrossRefGoogle Scholar
  16. Da Silva AL, da Silva Martins B, Linck Vde M, Herrmann AP, Mai N, Nunes DS et al (2009) MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a “brain tonic”. Psychopharmacology 202(1–3):165–172CrossRefGoogle Scholar
  17. Duke JA (2000) Handbook of phytochemical constituents of GRAS herbs and other economic plants. Herbal Reference Library. CRC Press, Boca Raton, p 497Google Scholar
  18. Elisabetsky E (1987) From indigenous disease concepts to laboratory working hypothesis: the case of “nerve tonics” from the Brazilian Amazon, Provisional Report Series, vol 19. International Foundation for Science, Stockholm, p S-11438Google Scholar
  19. Elisabetsky E, Netto CA, da Silva AL, Siqueira IS, Nunes DS (2005, December 20 ) BR Patent No PI 0307637-4 AGoogle Scholar
  20. Figueiró M, Ilha J, Pochmann D, Porciúncula LO, Xavier LL, Achaval M et al (2010) Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama). Phytomedicine 17(12):956–962CrossRefGoogle Scholar
  21. Figueiró M, Ilha J, Linck VM, Herrmann AP, Nardin P, Menezes CB et al (2011) The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model. Phytomedicine 18(4):327–333CrossRefGoogle Scholar
  22. Gallina G, Ferretti G, Merlanti R, Civitareale C, Capolongo F, Draisci R et al (2007) Boldenone, boldione, and milk replacers in the diet of veal calves: the effects of phytosterol content on the urinary excretion of boldenone metabolites. J Agric Food Chem 55(20):8275–8283CrossRefGoogle Scholar
  23. Gruenwald J, Brendler T, Jaenicke C (2000) PDR for herbal medicines. Thomson Medical Economics Co, Montvale, p 990Google Scholar
  24. Howes MJR, Houghton PJ (2012) Ethnobotanical treatment strategies against Alzheimer’s disease. Curr Alzheimer Res 9(1):67–85CrossRefGoogle Scholar
  25. Lorenzi H, Matos FJA (2002) Plantas medicinais no Brasil: nativas e exóticas, 2nd edn. Instituto Plantarum de Estudos da Flora, Nova Odessa, p 512Google Scholar
  26. Malécot V, Nickrent DL (2008) Molecular phylogenetic relationships of Olacaceae and related Santalales. Syst Bot: Am Soc Plant Taxonomists 33(1):97–106CrossRefGoogle Scholar
  27. Malécot V, Nickrent DL, Baas P, van den Oever L, Lobreau-Callen DA (2004) morphological cladistic analysis of Olacaceae. Syst Bot Am Soc Plant Taxonomists 29(3):569–586Google Scholar
  28. Mello JRB, Mello FB, Langeloh A (2010) Toxicity study of a phytotherapic with Anemopaegma mirandum, Cola nitida, Passiflora alata, Paullinia cupana, Ptychopetalum olacoides and thiamin in rabbits. Lat Am J Pharm 29(8):1431–1435Google Scholar
  29. Mendes FR (2011) Tonic, fortifier and aphrodisiac: adaptogens in the Brazilian folk medicine. Rev Bras Farmacog 21(4):754–763CrossRefGoogle Scholar
  30. Mendes FR, Carlini EA (2007) Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in Brazil. J Ethnopharmacol 109(3):493–500CrossRefGoogle Scholar
  31. Mendes FR, Negri G, Duarte-Almeida JM, Tabach R, Carlini EA (2012) The action of plants and their constituents on the central nervous system. In: Cechinel Filho V. Planta bioactives and drug discovery: principles, practice, and perspectives, 4th edn, pp 161–204CrossRefGoogle Scholar
  32. Novello C, Marques LC, Miyazaki CR, Milaneze-Gutierre MA, Carneiro-Torres DS, Sarragiotto MH, Mello JCP (2012) Morphoanatomy and pharmacognostic study of the wood of Croton echioides, the northeastern marapuama. Rev Bras Pharmacog 22(5):946–956CrossRefGoogle Scholar
  33. Oliveira CH, Moraes MEA, Moraes MO, Bezerra FAF, Abib E, De Nucci G (2005) Clinical toxicology study of an herbal medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers. Phytother Res 19(1):54–57CrossRefGoogle Scholar
  34. Paiva LAF, Rao VSN, Silveira ER (1998) Effects of Ptychopetalum olacoides extract on mouse behaviour in forced swimming and open field tests. Phytother Res 12(4):294–296CrossRefGoogle Scholar
  35. Peckolt T (1901) Heil und Nutzpflanzen Brasiliens. Ber Dtsch Pharm Ges 11:40Google Scholar
  36. Piato AL, Detanico BC, Jesus JF, Lhullier FLR, Nunes DS, Elisabetsky E (2008) Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties. J Ethnopharmacol 118(2):300–304CrossRefGoogle Scholar
  37. Piato AL, Rizon LP, Martins BS, Nunes DS, Elisabetsky E (2009) Antidepressant profile of Ptychopetalum olacoides Bentham (Marapuama) in mice. Phytother Res 23(4):519–524CrossRefGoogle Scholar
  38. Piato AL, Detanico BC, Linck VM, Herrmann AP, Nunes DS, Elisabetsky E (2010) Anti-stress effects of the “tonic” Ptychopetalum olacoides (Marapuama) in mice. Phytomedicine 17(3–4):248–253CrossRefGoogle Scholar
  39. Rolim A, Oishi T, Maciel CPM, Zague V, Pinto CASO, Kaneko TM et al (2006) Total flavonoids quantification from O/W emulsion with extract of Brazilian plants. Int J Pharm 308(1–2):107–114CrossRefGoogle Scholar
  40. Rossi AMA (2015) [Internet]. Olacaceae in Lista de Espécies da Flora do Brasil. Jardim Botânico do Rio de Janeiro. Access 2015. Available from: http://floradobrasil.jbrj.gov.br/
  41. Shanley P, Luz L, Swingland IR (2001) The faint promise of a distant market: a survey of Belém’s trade in non-timber forest products. Biodivers Conserv 11(4):615–636CrossRefGoogle Scholar
  42. Silva RAD (1925) Plantas medicinaes brasileiras. Estudo botanico e pharmacognostico. Muirapuama. Rev Bras Med Pharm 1(1):37–41 PortugueseGoogle Scholar
  43. Silva RAD (1926) Pharmacopeia dos Estados Unidos do Brasil. Companhia Editora Nacional, Rio de JaneiroGoogle Scholar
  44. Siqueira IR, Lara DR, Silva D, Gaieski FS, Nunes DS, Elisabetsky E (1998) Psychopharmacological Properties of Ptychopetalum olacoides bentham (Olacaceae). Pharm Biol 36(5):327–334CrossRefGoogle Scholar
  45. Siqueira IR, Cordova CAS, Creczynski-Pasa TB, Elisabetsky E, Nunes DS, Netto CA (2002) Antioxidant action of an ethanol extract of Ptychopetalum olacoides. Pharm Biol 40(5):374–379CrossRefGoogle Scholar
  46. Siqueira IR, Fochesatto C, da Silva AL, Nunes DS, Battastini AM, Netto CA et al (2003) Ptychopetalum olacoides, a traditional Amazonian “nerve tonic”, possesses anticholinesterase activity. Pharmacol Biochem Behav 75(3):645–650CrossRefGoogle Scholar
  47. Siqueira IR, Cimarosti H, Fochesatto C, Nunes DS, Salbego C, Elisabetsky E et al (2004) Neuroprotective effects of Ptychopetalum olacoides Bentham (Olacaceae) on oxygen and glucose deprivation induced damage in rat hippocampal slices. Life Sci 75(15):1897–1906CrossRefGoogle Scholar
  48. Siqueira IR, Fochesatto C, Torres ILS, da Silva AL, Nunes DS, Elisabetsky E et al (2007) Antioxidant activities of Ptychopetalum olacoides (“muirapuama”) in mice brain. Phytomedicine 14(11):763–769CrossRefGoogle Scholar
  49. Steinmetz EF (1962) Muira Puama (“Potency wood”). Pharm Biol 2:229–232Google Scholar
  50. Tang W, Hioki H, Harada K, Kubo M, Fukuyama Y (2008) Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides. J Nat Prod 71:1760–1763CrossRefGoogle Scholar
  51. Tang W, Kubo M, Harada K, Hioki H, Fukuyama Y (2009) Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides. Bioorg Med Chem Lett 19(3):882–886CrossRefGoogle Scholar
  52. Tang W, Harada K, Kubo M, Hioki H, Fukuyama Y (2011) Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides. Nat Prod Commun 6(3):327–332PubMedGoogle Scholar
  53. Toyota A, Ninomiya R, Kobayashi H, Kawanish K, Uhara Y, Kato A et al (1979) Studies of Brazilian crude drugs 1 muirapurama. Shoyakugaku Zasshi 33:57–64Google Scholar
  54. Tropicos.org (2015) [Internet]. Missouri Botanical Garden. Access 2015 Apr 16. Available from: http://www.tropicos.org
  55. Vaz ZR, Mata LV, Calixto JB (1997) Analgesic effect of the herbal medicine Catuama in thermal and chemical models of nociception in mice. Phyther Res 11(2):101–106CrossRefGoogle Scholar
  56. Waynberg J, Brewer S (2000) Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Adv Ther 17(5):255–262CrossRefGoogle Scholar
  57. Youngken HW (1921) Observations of Muira-Puama. J Am Pharm Assoc 10(9):690–692Google Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Leonardo Frasson dos Reis
    • 1
  • Fúlvio Rieli Mendes
    • 2
  1. 1.Centro de Matemática, Computação e CogniçãoUniversidade Federal do ABCSão Bernardo do CampoBrazil
  2. 2.Centro de Ciências Naturais e HumanasUniversidade Federal do ABCSão Bernardo do CampoBrazil

Personalised recommendations