Pluchea carolinensis (Jacq.) G. Don

  • Carles RoerschEmail author
Part of the Medicinal and Aromatic Plants of the World book series (MAPW, volume 5)


Pluchea carolinensis, is widely distributed in Central America, the Caribbean, the North of South America, and is naturalized in Florida, Hawaii, Islands of the Pacific, and Taiwan. The large number of common names given to P. carolinensis indicates the popularity of this medicinal plant. Also, the conformity in traditional uses between Spanish, French and English speaking cultures is remarkable. However, until now very few biological, pharmacological experiment are carried out to corroborate the traditional uses. Clinical experiments are completely absent. The anti-Leishmania activity of the extracts and pure compounds are promising.


Pluchea carolinensis Traditional uses Chemical compounds Anti-Leishmania activity 


  1. Acevedo-Rodriguez P, collaborators (1996) Flora of St. John, U.S. Virgin Islands. Mem N Y Bot Gard 78:1–581Google Scholar
  2. Ahmed AA, Ali BA, Krawiec M, Watson WH (1996) 5-O-Acetylcuauhtemonyl 6-O-2′,3′-epoxy-2′-methylbutyrate. Acta Crystallogr C52:235–237Google Scholar
  3. Ahmed AA, El-Seed HR, Mahmoud AA, El-Douski AEA, Zeid IF, Bohlin L (1998) Eudesmane derivates from Laggera crispata and Pluchea carolonesis. Phytochemistry 49(8):2421–2424CrossRefGoogle Scholar
  4. Alvarado-Guzmán JA, Gavillán-Suárez J, Germosén-Robineau L (2009) TRAMIL Ethnopharmacological survey: knowledge distribution of medicinal plant use in the southeast region of Puerto Rico. P R Health Sci J 28(4):329–339PubMedPubMedCentralGoogle Scholar
  5. Ankli A, Sticher O, Heinrich M (1999) Medical ethnobotany of the Yucatec Maya: healers’ consensus as a quantitative criterion. Econ Bot 53(2):144–160CrossRefGoogle Scholar
  6. Anonymous (2010) US Forest Service, Pacific Island Ecosystems at Risk (PIER). Online resource at Accessed: 15/02/11
  7. Arteaga ME, Payo AL, González C, Bada AM, González BO, Curbelo A (2008) Evaluación del extracto fluido de Pluchea carolinensis (Jacq.) G.Don. por el método de clases de toxicidad en ratas. Revista Cubana de Plantas Medicinales (on line) 13(4)Google Scholar
  8. Arvigo R, Balick M (1993) Rainforest remedies. One hundred healing herbs of Belize. Lotus Press, Twin LakesGoogle Scholar
  9. Austin DF (2004) Florida ethnobotany. CRC Press, Boca RatonCrossRefGoogle Scholar
  10. Bahadir O, Çitoğlu GS, Šmejkal K, Dall’Acqua S, Özbek H, Cvacka J, Zemlicka M (2010) Analgesic compounds from Scorzonera latifolia (Fisch. And Mey.) DC. J Ethnopharmacol 131:83–87CrossRefGoogle Scholar
  11. Balick MJ, Kronenberg F, Ososki AL, Reiff M, Fugh-Berman A, O’Conner B, Roble M, Lohr P, Atha D (2000) Medicinal plants used by Latino healers for women’s health conditions in New York City. Econ Bot 54(3):344–357CrossRefGoogle Scholar
  12. Barreto A, Pérez E, Reyes G, Enríquez N, Primelles J, Sedeño E (2002) Aportes al conocimiento de la riqueza florística para la gestión ambiental de la Sierra de Najasa. Camagüey Cuba Rodriguésia 53(82):131–145CrossRefGoogle Scholar
  13. Barreto A, Godínez D, Enríquez N, Reyes G (2007) Riqueza florística del complejo orográfico Sierra de Najasa, provincia Camagüey, Cuba. Rodriguésia 58(1):59–71CrossRefGoogle Scholar
  14. Barrett B (1994) Medicinal plants of Nicaragua’s Atlantic coast. Econ Bot 48(1):8–20CrossRefGoogle Scholar
  15. Beauvoir MG, Defillips RA, Wolpert BJ, Crepin J (2001) Selected medicinal plants of Haitian Vodou. Typescript. Smithsonian Institution, Washington, DCGoogle Scholar
  16. Beyra A, León M, Iglesias E, Ferrándiz D, Herrera R, Volpato G, Godínez D, Guimarais M, Álvarez R (2004) Estudios etnobotánicos sobre plantas medicinales en la provincia de Camagüey (Cuba). An Jard Bot Madr 61(2):185–203Google Scholar
  17. Biabiany M, Roumy V, Hennebelle T, François N, Sendid B, Pottier M, Aliouat E, Rouaud I, Lohézic-Le Dévéhat F, Joseph H, Bourgeois P, Sahpaz S, Bailleul F (2013) Antifungal activity of 10 Guadeloupian plants. Phytother Res 27:1640–1645CrossRefGoogle Scholar
  18. Bork PM, Schmitz ML, Kuhnt M, Escher C, Heinrich M (1997) Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF- κB. FEBS Lett 402:85–90CrossRefGoogle Scholar
  19. British Herbal Medicine Association (1983) British herbal pharmacopoeia. Bournemouth, EnglandGoogle Scholar
  20. Calderón JM, Burgos E, Pérez G, López M (2011) A review on the dietary flavonoid Kaempferol. Mini-Rev Med Chem 11:298–344CrossRefGoogle Scholar
  21. Cordero AB (1986) Manual de Medicina Domestica; Plantas Medicinales Dominicanas. Colección Ciencia y Tecnología no. 7, vol CCLII, 2nd edn. Publicaciones de la Universidad Autónoma de Santo Domingo, Santo DomingoGoogle Scholar
  22. Defilipps RA, Maina SL, Crepin J (2008) Medicinal plants of the Guianas (Guyana, Surinam, French Guiana). Smithsonian National Museum of Natural History, Smithsonian Inst, Washington, DCGoogle Scholar
  23. Dillon MO (2006) Nuevos registros de Asteraceae para la flora de Peru. New records in the Asteracea flora of Peru. Amaldoa 13(2):314–317Google Scholar
  24. Duke JA, Bogenschutz-Godwin MJ, Ottensen AR (2009) Duke’s handbook of medicinal plants of Latin America. CRC Press, Taylor & Francis Group, Boca RatonGoogle Scholar
  25. Eldridge J (1975) Bush medicine in the Exumas and Long Osland, Bahamas. A field study. Econ Bot 29:307–332CrossRefGoogle Scholar
  26. Englund RA, Imada C, Preston DJ (2002) Stream and botanical survey of an unnamed tributary flowing into Pu’u Ka ‘Ele reservoir and Pila’a stream, Pila’a, Kilauea, kaua’i, Final Report. Contribution No. 2002–001 to the Hawaii Biological Survey. Bishop Museum, Honolulu, Hawaii, USAGoogle Scholar
  27. Escandón M, Méndez M (2006) Enfermedades, insectos, y malezas observadas en Pluchea carolinensis (Jacq.) G. Don (Asteraceae) cultivada en el Instituto de Ecología y Sistemática. Accessed on 10 Feb 2011
  28. Feng PC, Hayes LJ, Magnus KE, Plimmer JR, Sherratt HSA (1962) Pharmacological screening of some West Indian medicinal plants. J Pharm Pharmacol 14:556–561CrossRefGoogle Scholar
  29. Fernández F, Torres M (2006) Evaluation of Pluchea carolinensis extracts as antioxidants by the epinephrine oxidation method. Fitoterapia 77:221–226CrossRefGoogle Scholar
  30. Fosberg FR, Sachet MH (1987) Flora of the Gilbert islands, Kiribati, checklist. The Smithsonian Institution, Washington, DCGoogle Scholar
  31. Frei B, Baltisberger M, Sticher O, Heinrich M (1998) Medical ethnobotany of the Zapotecs of the isthmus-sierra (Oaxaca, Mexico): documentation and assessment of indigenous uses. J Etnopharmacol 62:149–165CrossRefGoogle Scholar
  32. Fuentes VF, Granda MM, Armas I, Izquierdo M, Martínez M, Rodríguez CA (1989) Estudios sobre la medicina tradicional en Cuba. IV Rev Cubana Farm 23(1–2):99–115Google Scholar
  33. Garcia M, Monzote L, Montalvo AM, Scull R (2010) Screening of medicinal plants against Leishmania amazonensis. Pharm Biol 48(9):1053–1058CrossRefGoogle Scholar
  34. Garcia M, Perera WH, Scull R, Monzote L (2011) Antileishmanial assessment of leaf extracts from Pluchea carolinensis, Pluchea odorata and Pluchea rosea. Asian Pac J Trop Med:1836–1840Google Scholar
  35. Gillis WT (1977) Pluchea revisited. Taxon 26:587–591CrossRefGoogle Scholar
  36. Global Invasive Species Database (2008) Pluchea carolinensis. Available from: Accessed 9 Feb 2011
  37. Godfrey RK (1952) Pluchea, section Stylimnus, in North America. J Elisha Mitchell Sci Soc 68:238–279Google Scholar
  38. Godínez D, Volpato G (2008) Plantas medicinales que se venden en el mercado El Río, Camagüey, Cuba. Rev Mex Biodiversidad 79(1):243–259Google Scholar
  39. Goldsmith DJ, Sakano I (1976) Synthesis of Cuauhtemone. J Org Chem 41(12):2095–2098CrossRefGoogle Scholar
  40. Gómez-Beloz AG, Chávez N (2001) The Botánica as a culturally appropriate health care option for Latinos. J Altern Complement Med 7(5):537–546CrossRefGoogle Scholar
  41. Grieve M (n.d.) A modern herbal. Accessed 14 Mar 2012
  42. Gupta M (1995) 270 Plantas medicinales Iberoamericanas. CYTED-SECAB, BogotaGoogle Scholar
  43. Hammer K, Esquivel M, Fuentes V, Lima H (1990) Additional notes to the checklist of Cuban cultivated plants (1). Genet Resour Crop Ev 38(3):325–343Google Scholar
  44. Haslam E (1996) Natural polyphenols (vegetable tannins) as drugs: possible modes of action. J Nat Prod 59:205–215CrossRefGoogle Scholar
  45. Heinrich M (1989) Ethnobotanik der Tieflandmixe (Oaxaca, Mexico) und phytochemische Untersuchung von Capraria biflora L. (Scrophulariaceae). Dissertationes Botanicae No. 144. J.Cramer, Berlin and Stuttgart, GermanyGoogle Scholar
  46. Heinrich M, Rimpler H, Antonio N (1992) Indigenous phytotherapy of gastrointestinal disorders in a lowland Mixe community (Oaxaca, Mexico): ethnopharmacological evaluation. J Ethnopharmacol 36:63–80CrossRefGoogle Scholar
  47. Hernández J, Volpato G (2004) Herbal mixtures in the traditional medicine of eastern Cuba. J Ethnopharmacol 90:293–316CrossRefGoogle Scholar
  48. Hodges S, Bennett BC (2006) The ethnobotany of Pluchea carolinensis (Jacq.)G.Don (Asteraceae) in the Botánicas of Miami, Florida. Econ Bot 60(1):75–84CrossRefGoogle Scholar
  49. Honychurch PN (1986) Caribbean wild plants and their uses: an illustrated guide to some medicinal and wild ornamental plants of the West Indies. Macmillan Publishers, Ltd., LondonGoogle Scholar
  50. House PL, Witte S, Torres C (1990) Manual popular de 50 plantas medicinales de Honduras. CONS-H, CIIR, UNAH, HondurasGoogle Scholar
  51. Iijima K, Kiyohara H, Tanaka M, Matsumoto T, Cyong J, Yamada H (1995) Preventive effect of Taraxasteryl acetate from Inula britannica subsp. japonica on experimental hepatitis in vivo. Planta Med 61(1):50–53CrossRefGoogle Scholar
  52. Jakupovic J, Misra LN, Chau Thi TV, Bohlmann F, Castro V (1985) Cuauthemone derivates from Tessaria integrifolia and Pluchea symphytifolia. Phytochemistry 24(12):3053–3055CrossRefGoogle Scholar
  53. Khan R, Jarvis CE (1989) The correct name for the plant known as Pluchea symphythifolia (Miller) Gillis (Asteracea). Taxon 38:659–662CrossRefGoogle Scholar
  54. Kufer J, Förther H, Pöll E, Heinrich M (2005) Historical and modern medicinal plant uses – the example of the Ch’orti’ Maya and Ladinos in Eastern Guatemala. J Pharm Pharmacol 57:1127–1152CrossRefGoogle Scholar
  55. Lee HJ, Lee HJ, Ko SG, Bae HS, Kim CH, Ahn KS, Lu J, Kim SH (2008) Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin induced apoptosis. Cancer Lett 270(2):342–353CrossRefGoogle Scholar
  56. Lin LS (2009) Studies on the constituents of the roots and stems of Pluchea carolinensis (Jacq.) G.Don. Accessed on 10 Feb 2011
  57. Liogier AH (1990) Plantas medicinales de Puerto Rico y del Caribe. Iberoamericana Ediciones, Hato Rey, Puerto RicoGoogle Scholar
  58. Liogier AH (1996) La Flora de la Española, Vol. LXXII, serie Científica 29, vol VIII. Universidad Central del Este, San Pedro de Macorís, Dominican RepublicGoogle Scholar
  59. Liogier AH (2000) Diccionario Botánico de Nombres Vulgares de la Española, 2nd edn. Jardín Botánico “Dr. Rafael M. Moscoso” y Universidad Nacional Pedro Henriquez Ureña, Santo Domingo, Dominican RepublicGoogle Scholar
  60. Longuefosse J-L, Nossin E (1996) Medical ethnobotany survey in Martinique. J Ethnopharmacol 53:117–142CrossRefGoogle Scholar
  61. Ma G, Yang C, Qu Y, Wei H, Zhang T, Zhang N (2007) The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. Chem Biol Interact 167(2):153–160CrossRefGoogle Scholar
  62. Mañon DI, Haché Ll I, García SE (1992) Medicina Tradicional Dominicana (una contribución a su estudio). Universidad Nacional Pedro Henriquez Ureña, Academia Dominicana de Medicina, Museo del Hombre Dominicana, Instituto Dominicano de Ambiente y Sociedad, Santo Domingo, Dominican RepublicGoogle Scholar
  63. Milanés R, Alonso D, González G, Espín G (1999) Farmacognosia de la droga <Flores de Majagua> (Hibiscus elatus Sw., familia Malvaceae). I: farmacogeografia, farmacoetimología, farmacoergasia y farmacoetnología. Rev Cuba Plantas Medicinales 3(3):98–101Google Scholar
  64. Montrieux E, Perera WH, García M, Maes L, Cos P, Monzote L (2014) In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis. Parasitol Res 113:2925–2932CrossRefGoogle Scholar
  65. Morton JF (1981) Atlas of medicinal plants of middle America, Bahamas to Yucatan. Charles C. Thomas, Publisher, SpringfieldGoogle Scholar
  66. Morton JF (1981) Atlas of medicinal plants of middle America, Bahamas to Yucatan. Charles C. Thomas, Publisher, Springfield, USAGoogle Scholar
  67. Nakanishi K, Crouch R, Miura I, Dominguez X, Zamudio A, Villareal R (1974) Structure of a sesquiterpene, Cuauhtemone, and its derivative. Application of partially relaxed Fourier transform 13C nuclear magnetic resonance. J Am Chem Soc 96(2):609–611CrossRefGoogle Scholar
  68. Nuñez E (1992) Plantas Medicinales de Puerto Rico, Reimpresión. Editorial de la Universidad de Puerto Rico, Puerto RicoGoogle Scholar
  69. Palacios E, Déciga M, Mata R (2008) Antinociceptive, hypoglycemic and spasmolytic effects of Brickellia veronicifolia. J Ethnopharmacol 118:448–454CrossRefGoogle Scholar
  70. Peng C-I, Chen C-H, Leu W-P, Yen H-F (1998) Pluchea Cass. (Asteraceae: Inuleae) in Taiwan. Bot Bull Acad Sinica 39:287–297Google Scholar
  71. Perera WH (2012) Isolation and identification of antioxidant phytochemicals from Cuban species of the genera Erythroxylum P. Browne and Pluchea Cass. PhD Thesis, Laboratory of Molecular Biology and Plant Biotechnology, University of Liege, BelgiumGoogle Scholar
  72. Perera WH, González L, Payo, AL (2006a) Metabolitos secundarios y actividad antimicrobiana de Pluchea carolinensis. Revista Cubana de Farmacia; 40(2). ISSN 0034-7515
  73. Perera WH, González L, Payo AL, Nogueiras C, Delgado G, Oquendo M, Sarduy R (2006b) Antimicrobial activity of crude extracts and flavonoids from leaves of Pluchea carolinensis (Jacq.) G.Don. Pharmacol Ther 3:757–761Google Scholar
  74. Perera WH, Nogueiras C, Payo A, Queiroz B, Sarduy R, Oquendo M (2007) Flavonols from the leaves of Pluchea carolinensis (Jacq.) G.Don (Asteraceae). Rev Latinoamer Quim 35(3):68–73Google Scholar
  75. Perera WH, Tabart J, Gómez A, Sipel A, Payo AL, Kevers C, Dommes J (2010) Antioxidant capacity of three Cuban species of the genus Pluchea Cass. (Asteraceae). J Food Chem 34:249–261Google Scholar
  76. Pérez C, Balcinde Y, Suárez C, Hernández V, Falero A, Hung BR (2007) Ensayo de la actividad antimicrobiana de Pluchea carolinensis (salvia de playa). Rev CENIC Cienc Biológicas 38(2):150–154Google Scholar
  77. Peter SR (n.d.) Conservation of the biodiversity of medicinal plants in Barbados Accessed on 03 Apr 2008
  78. Pino JA, Marbot R, Payo A, Chao D, Herrera P, Martí MP (2005) Leaf oils of two Cuban Asteraceae species: Pluchea carolinensis Jacq. and Ambrosia hispida Pursh. J Essent Oil Res 17:318–320CrossRefGoogle Scholar
  79. Pino JA, Perera WH, Sarduy R, Oviedo R, Quijano CE (2009) Essential oil from flowers of Pluchea carolinensis (Jacq.) G.Don. J Essent Oil Res 21:45–47CrossRefGoogle Scholar
  80. Quinlan MB, Quinlan RJ (2007) Modernization and medicinal plant knowledge in a Caribbean horticultural village. Med Anthropol Q 21(2):169–192CrossRefGoogle Scholar
  81. Roig, Mesa JT (1928) Diccionario Botánico de Nombres Vulgares Cubanos. Imprenta y papeleria Ramela Bauzá y Cia, La Habana (On line by Ann Arbor Michigan, University of Michigan Library, 2005)Google Scholar
  82. Roig y Mesa JT (1965) Diccionario Botánico de Nombres Vulgares Cubanos. 3, ampliada y corregida. Editora del Consejo Nacional de Universidades, La Habana, CubaGoogle Scholar
  83. Rosales VP, Gross MC, Rosales RA, García RC, León JE (1999) Evaluación farmacológica de Pluchea carolinensis Jacq. (Salvia de playa) en animales de experimentación. Rev Cuba Plantas Medicinales 3(2):65–67Google Scholar
  84. Sardans J, Llusià J, Niinemets U, Owen S, Peñuelas J (2010) Foliar mono- and Sesquiterpene contents in relation to leaf economic spectrum in native and alien species in Oahu (Hawai’i). J Chem Ecol 36:210–226CrossRefGoogle Scholar
  85. Scholz E, Heinrich M, Hunkler D (1994) Caffeoylquinic acids and some biological activities of Pluchea symphytifolia. Planta Med 60(3):360–364CrossRefGoogle Scholar
  86. Seaforth CE, Adams CD, Sylvester YA (1983) Guide to the medicinal plants of Trinidad & Tobago. Commonwealth Secretariat, LondonGoogle Scholar
  87. Sharma SK, Goyal N (2011) Biological studies of the plants from the genus Pluchea. Ann Biol Res 2(3):25–34Google Scholar
  88. Slama R, Gillet C, William R, Longuefosse JL, Brunod R (2003) Histoire de la folie à la Martinique. Inf Psychiatr 79(6):493–499Google Scholar
  89. Space JC, Imada CT (2004) Report to the Republic of Kiribati on invasive plant species on the islands of Tarawa, Abemama, Butaritari and Maiana. U.S.D.A. Forest Service, Pacific Southwest Research Station, Institute of Pacific Islands Forestry, and Bishop Museum, Pacific Biological Survey, Department of Natural Sciences, Honolulu, Hawaii, USAGoogle Scholar
  90. Starr F, Starr K, Wood K. (2006) Lanai offshore islets botanical survey. Department of Land and Natural Resources, Division of Forestry and Wildlife and Offshore Islet Restoration Committee, Honolulu, Hawaii, USAGoogle Scholar
  91. Steggerda M (1943) Some ethnological data concerning one hundred Yucatan plants. Anthropological Papers no. 29, Smithsonian Institution, Bureau of American Ethnology Bulletin 136:189–226Google Scholar
  92. Teng BS, Lu YH, Wang ZT, Tao XY, Wei DZ (2006) In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells. Pharmacol Res 54(3):186–194CrossRefGoogle Scholar
  93. Ticktin T, Dalle SP (2005) Medicinal plant use in the practice of midwifery in rural Honduras. J Ethnopharmacol 96:233–248CrossRefGoogle Scholar
  94. Torres-Valencia JM, Quintero-Mogica DL, Léon GI, Suárez-Castillo OR, Villagómez-Ibarra JB, Maldonado E, Cerda-García-Rojas CM, Joseph-Nathan P (2003) The absolute configuration of cuauhtemone and related compounds. Tetrahedron Asymmetry 14:543–548CrossRefGoogle Scholar
  95. US Forest Service, Pacific Island Ecosystems at Risk (PIER) (n.d.) Online resource at Accessed 09-02-2011
  96. van Belle J (n.d.) Inventarisatie Terrestrisch Milieu van het eiland Aruba. RuG, the Netherlands. (without date)Google Scholar
  97. Villaseñor JL, Villareal JA (2006) El género Pluchea (familia Asteraceae, tribu Plucheea) in Mexico. Rev Mex Biodiversidad 77:59–65Google Scholar
  98. Volpato G, Godínez D, Beyra A, Barreto A (2009) Uses of medicinal plants by Haitian immigrants and their descendants in the Province of Camagüey, Cuba. J Ethnobiol Ethnomed 5:16CrossRefGoogle Scholar
  99. Wilder GJ, Roche BJ (2009) A floristic inventory of Marco Island (Collier County), Florida. J Bot Res Inst Tex 3(2):873–899Google Scholar
  100. Wood KR, LeGrande M (2006) An annotated checklist and new island records of flowering plants from Lehua Islet, Ni’ihau, Hawai’i. Records of the Hawaii Biological Survey for 2004–2005. In: Evenhuis NL, Eldredge LG (eds) Bishop Museum Occasional Papers, vol 87, pp 19–29Google Scholar
  101. Woodmansee SW, Green SE (2006) A floristic survey and rare plant assessment of Caloosahatchee Creek Preserve, Lee County, Florida, Final Report (abridged online version). The Institute for Regional Conservation, Miami, FloridaGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Herbario “Dr. Henri Alain Liogier”Universidad Nacional Pedro Henriquez Ureña (UNPHU)Santo DomingoDominican Republic

Personalised recommendations