Phyllanthus niruri L.

  • Valdir Cechinel FilhoEmail author
Part of the Medicinal and Aromatic Plants of the World book series (MAPW, volume 5)


Phyllanthus niruri L. (Euphorbiaceae), known as “quebra-pedra” or “stone breaker” is widely employed in folk medicine to treat ailments including disturbances of kidney and urinary bladder, intestinal infections, diabetes, hepatitis B virus, pain disorders, dyspepsia, vaginitis, tumors, diarrhea, epilepsy, malaria, hypertension, fever, inflammatory and dolorous processes. It is the most studied species of the Genus as regards chemical and biological aspects. Several experimental models have confirmed its medicinal properties, which are in general, related to the presence of phenolic compounds (flavonoids, tannins) and lignans. Interestingly, this plant was one of the first clinically studied species in Brazil, demonstrating the significant increase in renal calculi elimination.


Phyllanthus niruri Renal and urinary problems Phenolic compounds 


  1. Bagalkotar G, Sagineedu SR, Saad MS, Stanslas J (2006) Phytochemical from Phyllanhtus niruri Linn. and their pharmacological properties: a review. J Pharm Pharmacol 58:1559–1570CrossRefGoogle Scholar
  2. Calixto JB, Santos ARSS, Cechinel Filho V, Yunes RA (1998) A review of the plants of the genus Phyllanthus: their chemistry, pharmacology and therapeutic potential. Med Res Rev 18(4):225–258CrossRefGoogle Scholar
  3. Da Silva MJ, Sales MF (2008) Sinopse do gênero Phyllanthus (Phyllanthaceae) no nordeste do Brasil. Rodriguésia 59(2):407–422CrossRefGoogle Scholar
  4. De Melo MN, Soares LA, Porto CR, De Araújo AA, Almeida MD, De Souza TP, Petrovick PR, De Araújo RF Jr, Guerra GC (2015) Spray-dried extract of Phyllanthus niruri L. reduces mucosal damage in rats with intestinal inflammation. J Pharm Pharmacol 67:1107–1118CrossRefGoogle Scholar
  5. Gupta MP (ed) (2008) Plantas medicinales iberoamericanas. Convenio Andrés Bello y CYTED, Bogotá, pp 415–425Google Scholar
  6. Ibrahim D, Hong LS, Kuppan N (2013) Antimicrobial activity of crude methanolic extract from Phyllanthus niruri. Nat Prod Comm 8(4):493–496Google Scholar
  7. Liu S, Wei W, Li Y, Lin X, Shi K, Cao X, Zhou M (2014a) In vitro and in vivo anti-hepatitis B virus activities of the lignan nirtetralin B isolated from Phyllanthus niruri L. J Ethnopharmacol 157:62–68CrossRefGoogle Scholar
  8. Liu S, Wei W, Shi K, Cao X, Zhou M, Liu Z (2014b) In vitro and in vivo anti-hepatitis B virus activities of the lignan niranthin isolated from Phyllanthus niruri L. J Ethnopharmacol 155:1061–1067CrossRefGoogle Scholar
  9. Mediani A, Abas F, Khatib A, Tan CP, Ismail IS, Shaari K, Ismail A, Lajis NH (2015) Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction. Plant Foods Hum Nutr 70, 184–192CrossRefGoogle Scholar
  10. Miguel OG, Calixto JB, Santos AR, Messana I, Ferrari F, Cechinel Filho V, Pizzolatti MG, Yunes RA (1996) Chemical and preliminary analgesic evaluation of geraniin and furosin isolated from Phyllanthus sellowianus. Planta Med 62(2):146–149CrossRefGoogle Scholar
  11. Moreira J, Klein-Júnior LC, Cechinel Filho V, de Campos Buzzi F (2013) Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae). J Ethnopharmacol 146(1):318–323CrossRefGoogle Scholar
  12. Qi W, Hua L, Gao K (2014) Chemical constituents of the plants from the Genus Phyllanthus. Chem Biodivers 11:364–395CrossRefGoogle Scholar
  13. Santos ARS, Cechinel Filho V, Yunes RA, Calixto JB (1995) Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus. Gen Pharmacol 26(7):1499–1506CrossRefGoogle Scholar
  14. Ulysséa M, Amaral LG (1997) Contribution to the study of the genus Phyllanthus (Euphorbiaceae) in Santa Catarina island. Brazil Insula 26:1–28Google Scholar
  15. Webster GL (1956) Studies of the Euphorbiaeeae, Phyllanthoideae. 11. The american species of Phyllanthus described by Linnaeus. J Arnold Arb 37:1–14Google Scholar
  16. Webster GL (1970) A revision of Phyllanthus (Euphorbiaeeae) in the Continental United States. Brittonia 22:44–76CrossRefGoogle Scholar

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© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Programa de Pós-Graduação em Ciências, Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)Universidade do Vale do Itajaí (UNIVALI)ItajaíBrazil

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