Malignant Peritoneal Mesothelioma
In 1908, Miller and Wynn firstly described a malignant mesothelioma (MPM), a type of aggressive and dismal malignancies that originates in the serosal layer of pleura, peritoneum, pericardium, and tunica vaginalistestis. MPM is mostly located in the pleural region and accounts for 30% of all mesotheliomas, with an estimated annual incidence of approximately 10,000 cases in China. Notably, the prevalence of MPM has been increased rapidly worldwide since 1970 and is not expected to reach the peak in another 1–2 decades. It has been reported that the lifetime probability of developing a peritoneal mesothelioma is 1/10,000 in women and 1–1.5/10,000 in men. In developed countries, MPM is the most common peritoneal malignancy. Because of high malignancy and frequent recurrence, either untreated or conventionally treated, the life expectancy of patients is restricted to be 4–12 months.
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