Retroperitoneal Neurilemmoma

  • Cheng-Hua Luo
  • Xueyan Lv


Retroperitoneal neurilemmoma is a rare benign tumor originated in the retroperitoneal spinal nerve sheath. Its malignant transformation is extremely rare. Neurilemmoma was firstly described by Verocay and also called Schwann’s tumor (Stout, 1946) because of Schwann’s cellular origin. In recent years, some studies suggest that Schwann’s cells with multiple differentiation potential can form a variety of mesenchymal cells and transform backward to the original neuroepithelial cells. Therefore, Schwann’s cells are not only neurilemmoma cells but also metrocytes of soft tissue tumors. Malignant neurilemmomas usually are transformed from neurofibromas or neurofibromatosis; however, benign neurilemmoma rarely undergoes malignant transformation. Both benign and malignant neurilemmomas are very rare, commonly seen in people aged 20–50 years, with the incidence rate approximately equivalent between men and women.


  1. Murray MR, Stout AP, Bradley CF. Schwann cell versus fibroblast as the origin of the specific nerve sheath tumor: observations upon normal nerve sheaths and neurilemomas in vitro. Am J Pathol. 1940;16(1):41–60. 17PubMedPubMedCentralGoogle Scholar
  2. Stout AP. Neurofibroma and neurilemoma. Clin Proc. 1946; 5:1–12Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2018

Authors and Affiliations

  1. 1.Peking University International HospitalBeijingChina

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