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TRPC Channels and Neuron Development, Plasticity, and Activities

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 976)

Abstract

In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity. We also notice emerging advances in understanding the functions of TRPC channels in periphery, especially their functions in sensation and nociception in dorsal root ganglion (DRG). Because TRPC channels are expressed in all major types of glial cells, which account for at least half of total cells in the brain, TRPC channels may act as modulators for glial functions as well. The future challenges for studying these channels could be (1) the detailed protein structures of these channels, (2) their cell type-specific functions, (3) requirement for their specific blockers or activators, and (4) change in the channel conformation in the brain.

Keywords

  • TRPC channels
  • Neuron
  • Development
  • Plasticity

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Fig. 9.1

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Acknowledgment

Dr. Yichang Jia acknowledges the funding support from “1000-talents Plan” for young researchers, the Chinese Central Government; from Peking-Tsinghua Joint Center for Life Sciences and IDG/McGovern Institute for Brain Research at Tsinghua; from National Science Foundation of China (31571097, 81371361); from ALS association (16-IIP-284); and from NIH Pathway to Independence Award (K99/R00, NS079476).

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Tai, Y., Jia, Y. (2017). TRPC Channels and Neuron Development, Plasticity, and Activities. In: Wang, Y. (eds) Transient Receptor Potential Canonical Channels and Brain Diseases. Advances in Experimental Medicine and Biology, vol 976. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1088-4_9

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