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TRPC Channels and Stroke

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Transient Receptor Potential Canonical Channels and Brain Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 976))

Abstract

TRPC channels play important roles in neuronal death/survival in ischemic stroke, vasospasm in hemorrhagic stroke, thrombin-induced astrocyte pathological changes, and also in the initiation of stroke by affecting blood pressure and atherogenesis. TRPCs’ unique channel characters and downstream pathways make them possible new targets for stroke therapy. TRPC proteins have different functions in different cell types. Considering TRPCs’ extensive distribution in various tissues and cell types, drugs targeting them could induce more complicated effects. More specific agonists/antagonists and antibodies are required for future study of TRPCs as potential targets for stroke therapy.

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  1. Toronto Western Hospital Research Institute, Toronto, ON, Canada

    Junbo Huang

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Correspondence to Junbo Huang .

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  1. Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, China

    Yizheng Wang

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Huang, J. (2017). TRPC Channels and Stroke. In: Wang, Y. (eds) Transient Receptor Potential Canonical Channels and Brain Diseases. Advances in Experimental Medicine and Biology, vol 976. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1088-4_6

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