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Genetic Aberrations and Molecular Pathways in Head and Neck Cancer

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Squamous cell Carcinoma

Abstract

In this chapter, we provide a comprehensive overview of common genetic aberrations so far discovered in head and neck cancer. We discuss how these genetic alterations may affect protein structure and function. We also highlight the latest discoveries in signalling pathways affected as a result of these genetic aberrations. A better understanding of these mechanisms underlying cancer formation, progression and resistance to therapy leads us to the next five chapters that discuss each of the key driver mutations and tumour suppressors that are lost in head and neck cancer.

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Author information

Authors and Affiliations

  1. Department of Medicine and Oral Surgery, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Instituto Universitário de Ciências da Saúde (IUCS), CESPU, Gandra, Portugal

    Luis Monteiro

  2. Oral Medicine and Experimental Pathology, King’s College London, London, UK

    Saman Warnakulasuriya

Authors
  1. Luis Monteiro
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  2. Saman Warnakulasuriya
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Corresponding author

Correspondence to Luis Monteiro .

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Editors and Affiliations

  1. Oral Medicine, King's College London Oral Medicine, Surrey, United Kingdom

    Saman Warnakulasuriya

  2. Cedars-Sinai Medical Center, Department of Biomedical Sciences Cedars-Sinai Medical Center, Los Angeles, California, USA

    Zakir Khan

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Monteiro, L., Warnakulasuriya, S. (2017). Genetic Aberrations and Molecular Pathways in Head and Neck Cancer. In: Warnakulasuriya, S., Khan, Z. (eds) Squamous cell Carcinoma. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1084-6_4

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