Abstract
Two main functions of taurine in the brain are here discussed: the role of taurine in cell volume regulation and the neuromodulatory actions of taurine liberated by depolarization. Taurine takes part in cell volume regulation with other small-molecular compounds. Extracellular taurine inhibits neuronal firing through GABA and glycine receptors. However, the existence of specific taurine receptors is still not excluded.
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References
Ament ME, Geggel HS, Heckenlively JR, Martin DA, Kopple JD (1986) Taurine supplementation in infants receiving long-term total parenteral nutrition. J Am Coll Nutr 5:127–135
David-Watine B, Goblet C, de Saint JD, Fucile S, Devignot V, Bregestovski P, Korn H (1999) Cloning, expression and electrophysiological characterization of glycine receptor alpha subunit from zebrafish. Neuroscience 90:303–317
El Idrissi A (2006) Taurine and brain excitability. Adv Exp Med Biol 583:315–322
Guevara-Guzman R, Emson PC, Kendrick KM (1994) Modulation of in vivo striatal transmitter release by nitric oxide and cyclic GMP. J Neurochem 62:807–810
Hilgier W, Oja SS, Saransaari P, Albrecht J (2005) Taurine prevents ammonia-induced accumulation of cyclic AMP in rat striatum by interaction with GABAA and glycine receptors. Brain Res 1043:242–246
Horikoshi T, Asanuma A, Yanagisawa K, Anzai K, Goto S (1988) Taurine and β-alanine act on both GABA and glycine receptors in Xenopus oocyte injected with mouse brain messenger RNA. Brain Res 464:97–105
Imaki H, Moretz RC, Wisniewski HM, Sturman JA (1986) Feline maternal taurine deficiency: effects on retina and tapetum of the offspring. Dev Neurosci 8:160–181
Jacobson I, Hamberger A (1985) Kainic acid-induced changes of extracellular amino acid levels, evoked potentials and EEG activity in the rabbit olfactory bulb. Brain Res 348:289–296
Kimelberg HK, Goderie SK, Higman S, Pang S, Waniewski RA (1990) Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J Neurosci 10:1583–1591
Kontro P, Oja SS (1987a) Glycinergic systems in the brain stem of developing and adult mice: effects of taurine. Int J Dev Neurosci 5:461–470
Kontro P, Oja SS (1987b) Taurine and GABA release from mouse cerebral cortex slices: potassium stimulation releases more taurine than GABA from developing brain. Dev Brain Res 37:277–291
Lerma J, Herranz AS, Herreras O, Abraira V, Martín del Río R (1986) In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Res 384:145–155
Malminen O, Kontro P (1987) Actions of taurine on the GABA-benzodiazepine receptor complex solubilized from rat brain. Neurochem Int 11:113–117
Molchanova S, Kööbi P, Oja SS, Saransaari P (2004) Interstitial concentrations of amino acids during global forebrain ischemia and potassium-evoked spreading depression. Neurochem Res 29:1519–1527
Oja SS, Saransaari P (1992) Taurine release and swelling of cerebral cortex slices from adult and developing mice in media of different ionic composition. J Neurosci Res 32:551–561
Oja SS, Saransaari P (1996) Kinetic analysis of taurine influx into cerebral cortical slices from adult and developing mice in different incubation conditions. Neurochem Res 21:161–166
Oja SS, Saransaari P (2007) Taurine. In: Lajtha A, Oja SS, Schousboe A, Saransaari P (eds) Handbook of neurochemistry and molecular neurobiology, Amino acids and peptides in the nervous system, vol 6, 3rd edn. Springer, New York, pp 155–206
Oja SS, Uusitalo AJ, Vahvelainen ML, Piha RS (1968) Changes in cerebral and hepatic amino acids in the rat and guinea pig during development. Brain Res 11:655–661
Oja SS, Korpi ER, Saransaari P (1990) Modification of chloride flux across brain membranes by inhibitory amino acids in developing and adult mice. Neurochem Res 15:797–804
Pasantes-Morales H, Franco R (2002) Influence of protein tyrosine kinases and cell volume change-induced taurine release. Cerebellum 1:103–109
Pasantes-Morales H, Schousboe A (1988) Volume regulation in astrocytes: a role of taurine as an osmoeffector. J Neurosci Res 20:505–509
Pasantes-Morales H, Schousboe A (1997) Role of taurine in osmoregulation in brain cells: mechanisms and functional implications. Amino Acids 12:281–292
Saransaari P, Oja SS (2002) Taurine release in the developing and adult mouse hippocampus: involvement of cyclic guanosine monophosphate. Neurochem Res 27:15–20
Saransaari P, Oja SS (2003) Characterization of N-methyl-D-aspartate-evoked taurine release in the developing and adult mouse hippocampus. Amino Acids 24:213–221
Saransaari P, Oja SS (2008) Taurine in neurotransmission. In: Lajtha A, Vizi ES (eds) Handbook of neurochemistry and molecular neurobiology, Neurotransmitter systems, vol 2, 3rd edn. Springer, New York, pp 326–342
Scheller D, Korte M, Szathmary S, Tegtmeier F (2000) Cerebral taurine release mechanisms in vivo: pharmacological investigation in rats using microdialysis for proof of principle. Neurochem Res 25:801–807
Schousboe A, Pasantes-Morales H (1989) Potassium-stimulated release of [3H]taurine from cultured GABAergic and glutamatergic neurons. J Neurochem 53:1309–1315
Solís JM, Herranz AS, Herreras O, Lerma J, Martín del Río R (1988) Low chloride-dependent release of taurine by a furosemide-sensitive process in the in vivo rat hippocampus. Neuroscience 24:885–891
Walz W, Allen AF (1987) Evaluation of the osmoregulatory function of taurine in brain cells. Exp Brain Res 68:290–298
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Oja, S.S., Saransaari, P. (2017). Significance of Taurine in the Brain. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_8
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DOI: https://doi.org/10.1007/978-94-024-1079-2_8
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