Abstract
WHO-CARDIAC (Cardiovascular Diseases and Alimentary Comparison) Study revealed the quintile analyses of 24-h urinary (24 U) taurine (T) and magnesium (Mg) excretions were inversely related with cardiometabolic risks (CMR) such as obesity, hypertension and hypercholesterolemia in 50 population samples in the world. To exclude the influence of ethnicity in the study, 24 U T and Mg excretions were analyzed for the association with CMR in one ethnicity, Japanese population.
24 U T/creatinine (C) ratios were divided into 5 quintiles and the ratios of Japanese to the total of each quintile were analyzed from CARDIAC Study samples. The highest 24 U T quintile consisted of 60% Japanese, indicating high seafood consumption in Japanese.
Over 600 Japanese aged 30–79 were invited to a health examination for blood pressure measurement and for fasting blood and 24 U samplings. Tertile analysis of 24 U T/C ratios in relation to CMR indicated the third tertile had significantly higher HDL cholesterol, 24 U potassium (K) and 24 U salt than the first (lowest) tertile. Tertile analysis of 24 U Mg/C ratios indicated the third tertile had significantly lower body mass index and significantly higher folic acid, 24 U isoflavones, K and salt than the first tertile after age and gender adjustment. The third tertile of both T/C and Mg/C had significantly lower body mass index, LDL/HDL and Na/K ratios, and significantly higher HDL cholesterol and folic acid than the first tertile, indicating seafood eaters taking Mg rich diets had lower risks of obesity, atherosclerosis, hypertension and higher folic acid, beneficial for healthy longevity.
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Abbreviations
- 24 U:
-
24-hour urine
- BP:
-
Blood pressure
- C:
-
Creatinine
- CMR:
-
Cardiometabolic risks
- HDL:
-
High density lipoprotein
- HOMA-IR:
-
Homeostasis model of assessment of insulin resistance
- K:
-
Potassium
- Mg:
-
Magnesium
- T:
-
Taurine
- WHO:
-
World Health Organization
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Acknowledgements
We express our appreciation to all participants in WHO-CARDIAC Study as well as in the health examination by Hyogo Prefecture Health Promotion Association (HPHPA). This work was supported by JSPS KAKENHI Grant Number A 20256001 and by HPHPA.
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Yamori, Y. et al. (2017). Taurine Intake with Magnesium Reduces Cardiometabolic Risks. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_80
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DOI: https://doi.org/10.1007/978-94-024-1079-2_80
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