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Case Studies: Function Predictions of Structural Genomics Results

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From Protein Structure to Function with Bioinformatics

Abstract

The various Structural Genomics initiatives around the globe succeeded in solving several thousand protein structures, many of which were novel folds or structures of biological interest. Nevertheless, because of the high-throughput strategies employed, a significant proportion of the proteins were of unknown function, and remain so to this day. A number of computational methods have been developed to help ascertain protein function from three dimensional structure, the approaches ranging from large scale fold comparison to highly specific residue template matching. Each has its own advantages and disadvantages. Here we look at various analyses conducted to assess function prediction from structure, with specific examples of some of the success stories.

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Acknowledgements

The authors would like to thank Vicky Schneider for her useful comments on the first version of this chapter.

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Authors and Affiliations

  1. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK

    James D. Watson, Roman A. Laskowski & Janet M. Thornton

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  1. James D. Watson
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  2. Roman A. Laskowski
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  3. Janet M. Thornton
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Correspondence to Janet M. Thornton .

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  1. Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

    Daniel J. Rigden

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Watson, J.D., Laskowski, R.A., Thornton, J.M. (2017). Case Studies: Function Predictions of Structural Genomics Results. In: J. Rigden, D. (eds) From Protein Structure to Function with Bioinformatics. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1069-3_14

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