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Aquaporins and Gland Secretion

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Aquaporins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 969))

Abstract

Aquaporins (AQPs ) are expressed in most exocrine and endocrine secretory glands. Consequently, summarizing the expression and functions of AQPs in secretory glands represents a daunting task considering the important number of glands present in the body, as well as the number of mammalian AQPs – thirteen. The roles played by AQPs in secretory processes have been investigated in many secretory glands. However, despite considerable research, additional studies are clearly needed to pursue our understanding of the role played by AQPs in secretory processes. This book chapter will focus on summarizing the current knowledge on AQPs expression and function in the gastrointestinal tract , including salivary glands, gastric glands, Duodenal Brunner’s gland, liver and gallbladder, intestinal goblets cells, exocrine and endocrine pancreas, as well as few other secretory glands including airway submucosal glands, lacrimal glands, mammary glands and eccrine sweat glands.

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References

  1. Abdul-Wahab A, Takeichi T, Liu L, Lomas D, Hughes B, Akiyama M, McGrath JA, Mellerio JE (2015) Autosomal dominant diffuse non-epidermolytic palmoplantar keratoderma due to a recurrent mutation in aquaporin-5. Brit J Dermatol 174(2):430–432 [PubMed: 26032342]

    Article  CAS  Google Scholar 

  2. Abu-Hamdah R, Cho WJ, Cho SJ, Jeremic A, Kelly M, Ilie AE, Jena BP (2004) Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex. Cell Biol Int 28:7–17 [PubMed: 14759764]

    Article  CAS  PubMed  Google Scholar 

  3. Akamatsu T, Parvin MN, Murdiastuti K, Kosugi-Tanaka C, Yao C, Miki O, Kanamori N, Hosoi K (2003) Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland. Pflugers Arch Eur J Physiol 446:641–651 [PubMed: 12838423]

    Article  CAS  Google Scholar 

  4. Amano O, Mizobe K, Bando Y, Sakiyama K (2012) Anatomy and histology of rodent and human major salivary glands: -overview of the Japan salivary gland society-sponsored workshop. Acta Histochem Cytochem 45:241–250 [PubMed: 23209333]

    Article  PubMed  PubMed Central  Google Scholar 

  5. Asari T, Maruyama K, Kusama H (2009) Salivation triggered by pilocarpine involves aquaporin-5 in normal rats but not in irradiated rats. Clin Exp Pharmacol Physiol 36:531–538 [PubMed: 19673936]

    Article  CAS  PubMed  Google Scholar 

  6. Aure MH, Ruus AK, Galtung HK (2014) Aquaporins in the adult mouse submandibular and sublingual salivary glands. J Mol Histol 45:69–80 [PubMed: 23880985]

    Article  CAS  PubMed  Google Scholar 

  7. Ballard ST, Inglis SK (2004) Liquid secretion properties of airway submucosal glands. J Physiol 556:1–10 [PubMed: 14660706]

    Article  CAS  PubMed  Google Scholar 

  8. Baum BJ, Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Goldsmith CM, Burbelo PD, Citrin DE, Mitchell JB, Nottingham LK, Rudy SF, Van Waes C, Whatley MA, Brahim JS, Chiorini JA, Danielides S, Turner RJ, Patronas NJ, Chen CC, Nikolov NP, Illei GG (2012) Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proc Natl Acad Sci U S A 109:19403–19407 [PubMed: 23129637]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Baum BJ, Zheng C, Cotrim AP, Goldsmith CM, Atkinson JC, Brahim JS, Chiorini JA, Voutetakis A, Leakan RA, Van Waes C, Mitchell JB, Delporte C, Wang S, Kaminsky SM, Illei GG (2006) Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction. Biochim Biophys Acta 1758:1071–1077 [PubMed: 16368071]

    Article  CAS  PubMed  Google Scholar 

  10. Beroukas D, Hiscock J, Gannon BJ, Jonsson R, Gordon TP, Waterman SA (2002) Selective down-regulation of aquaporin-1 in salivary glands in primary Sjogren’s syndrome. Lab Investig 82:1547–1552 [PubMed: 12429814]

    Article  CAS  PubMed  Google Scholar 

  11. Beroukas D, Hiscock J, Jonsson R, Waterman SA, Gordon TP (2001) Subcellular distribution of aquaporin 5 in salivary glands in primary Sjogren’s syndrome. Lancet 358:1875–1876 [PubMed: 11741631]

    Article  CAS  PubMed  Google Scholar 

  12. Best L, Brown PD, Yates AP, Perret J, Virreira M, Beauwens R, Malaisse WJ, Sener A, Delporte C (2009) Contrasting effects of glycerol and urea transport on rat pancreatic beta-cell function. Cell Physiol Biochem 23:255–264 [PubMed: 19471093]

    Article  CAS  PubMed  Google Scholar 

  13. Best L, Miley HE, Yates AP (1996) Activation of an anion conductance and beta-cell depolarization during hypotonically induced insulin release. Exp Physiol 81:927–933 [PubMed: 8960699]

    Article  CAS  PubMed  Google Scholar 

  14. Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJ, Wilson NJ, McLean WH, Munro CS, South AP, Leigh IM, O’Toole EA, Lundstrom A, Kelsell DP (2013) Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. Am J Hum Genet 93:330–335 [PubMed: 23830519]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Bovell DL, Lindsay SL, Corbett AD, Steel C (2006) Immunolocalization of aquaporin-5 expression in sweat gland cells from normal and anhidrotic horses. Vet Dermatol 17:17–23 [PubMed: 16412116]

    Article  PubMed  Google Scholar 

  16. Boyer JL (2013) Bile formation and secretion. Commun Phys 3:1035–1078 [PubMed: 23897680]

    Google Scholar 

  17. Burghardt B, Elkaer ML, Kwon TH, Racz GZ, Varga G, Steward MC, Nielsen S (2003) Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut 52:1008–1016 [PubMed: 12801959]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Burghardt B, Nielsen S, Steward MC (2006) The role of aquaporin water channels in fluid secretion by the exocrine pancreas. J Membr Biol 210:143–153 [PubMed: 16868672]

    Article  CAS  PubMed  Google Scholar 

  19. Calamita G, Mazzone A, Bizzoca A, Cavalier A, Cassano G, Thomas D, Svelto M (2001) Expression and immunolocalization of the aquaporin-8 water channel in rat gastrointestinal tract. Eur J Cell Biol 80:711–719 [PubMed: 11824790]

    Article  CAS  PubMed  Google Scholar 

  20. Calamita G, Ferri D, Gena P, Liquori GE, Marinelli RA, Meyer G, Portincasa P, Svelto M (2005) Water transport into bile and role in bile formation. Curr Drug Targets 5:137–142 [PubMed: 16089345]

    CAS  Google Scholar 

  21. Calamita G, Gena P, Ferri D, Rosito A, Rojek A, Nielsen S, Marinelli RA, Fruhbeck G, Svelto M (2012) Biophysical assessment of aquaporin-9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol. Biol Cell 104:342–351 [PubMed: 22316404]

    Article  CAS  PubMed  Google Scholar 

  22. Calamita G, Delporte C, Marinelli PA (2015) Hepatobiliary, salivary glands and pancreatic aquaporins in health and disease. In: Soveral G, Nielsen S, Casini A (eds) Aquaporins in heath and disease: new molecular targets for drug discovery. CRC Press, Boca Raton, pp 183–205

    Google Scholar 

  23. Cao X, Yin J, Wang H, Zhao J, Zhang J, Dai L, Jiang H, Lin Z, Yang Y (2014) Mutation in AQP5, encoding aquaporin 5, causes palmoplantar keratoderma Bothnia type. J Invest Dermatol 1:284–287 [PubMed: 23867895]

    Article  CAS  Google Scholar 

  24. Carmosino M, Procino G, Tamma G, Mannucci R, Svelto M, Valenti G (2007) Trafficking and phosphorylation dynamics of AQP4 in histamine-treated human gastric cells. Biol Cell 99:25–36 [PubMed: 16895520]

    Article  CAS  PubMed  Google Scholar 

  25. Catalan V, Gomez-Ambrosi J, Pastor C, Rotellar F, Silva C, Rodriguez A, Gil MJ, Cienfuegos JA, Salvador J, Vendrell J, Fruhbeck G (2008) Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. Obes Surg 18:695–701 [PubMed: 18401671]

    Article  PubMed  Google Scholar 

  26. Ceperuelo-Mallafre V, Miranda M, Chacon MR, Vilarrasa N, Megia A, Gutierrez C, Fernandez-Real JM, Gomez JM, Caubet E, Fruhbeck G, Vendrell J (2007) Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. J Clin Endocrinol Metab 92:3640–3645 [PubMed: 17566090]

    Article  CAS  PubMed  Google Scholar 

  27. Chen J, Wang T, Zhou YC, Gao F, Zhang ZH, Xu H, Wang SL, Shen LZ (2014) Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer. J Exp Clin Cancer Res 33:38 [PubMed: 24887009]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Cho G, Bragiel AM, Wang D, Pieczonka TD, Skowronski MT, Shono M, Nielsen S, Ishikawa Y (2015) Activation of muscarinic receptors in rat parotid acinar cells induces AQP5 trafficking to nuclei and apical plasma membrane. Biochim Biophys Acta 1850:784–793 [PubMed: 25603543]

    Article  CAS  PubMed  Google Scholar 

  29. Cho SJ, Sattar AK, Jeong EH, Satchi M, Cho JA, Dash S, Mayes MS, Stromer MH, Jena BP (2002) Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles. Proc Natl Acad Sci U S A 99:4720–4724 [PubMed: 11917120]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Choi JH, Wu HG, Jung KC, Lee SH, Kwon EK (2009) Apoptosis and expression of AQP5 and TGF-beta in the irradiated rat submandibular gland. Cancer Res Treat 41:145–154 [PubMed: 19809564]

    Article  PubMed  PubMed Central  Google Scholar 

  31. Collaco AM, Jakab RL, Hoekstra NE, Mitchell KA, Brooks A, Ameen NA (2013) Regulated traffic of anion transporters in mammalian Brunner’s glands: a role for water and fluid transport. Am J Physiol Gastrointest Liver Physiol 305:G258–G275 [PubMed: 23744739]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Dartt DA, Moller M, Poulsen JH (1981) Lacrimal gland electrolyte and water secretion in the rabbit: localization and role of (Na+ + K+)-activated ATPase. J Physiol 321:557–569 [PubMed: 6461755]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Delporte C (2014) Aquaporins in salivary glands and pancreas. Biochim Biophys Acta 1840:1524–1532 [PubMed: 23954206]

    Article  CAS  PubMed  Google Scholar 

  34. Delporte C, O’Connell BC, He X, Lancaster HE, O’Connell AC, Agre P, Baum BJ (1997) Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci U S A 97:3268–3273 [PubMed: 9096382]

    Article  Google Scholar 

  35. Delporte C, Virreira M, Crutzen R, Louchami K, Sener A, Malaisse WJ, Beauwens R (2009) Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11. J Cell Physiol 221:424–429 [PubMed: 19585522]

    Article  CAS  PubMed  Google Scholar 

  36. Ding C, Nandoskar P, Lu M, Thomas P, Trousdale MD, Wang Y (2011) Changes of aquaporins in the lacrimal glands of a rabbit model of Sjogren’s syndrome. Curr Eye Res 36:571–578 [PubMed: 21524183]

    Article  PubMed  PubMed Central  Google Scholar 

  37. Ding C, Parsa L, Nandoskar P, Zhao P, Wu K, Wang Y (2010) Duct system of the rabbit lacrimal gland: structural characteristics and role in lacrimal secretion. Invest Ophthalmol Vis Sci 51:2960–2967 [PubMed: 20107177]

    Article  PubMed  PubMed Central  Google Scholar 

  38. Drews G, Krippeit-Drews P, Dufer M (2010) Oxidative stress and beta-cell dysfunction. Pflugers Arch Eur J Physiol 460:703–718 [PubMed: 20652307]

    Article  CAS  Google Scholar 

  39. Elkjaer M, Vajda Z, Nejsum LN, Kwon T, Jensen UB, Amiry-Moghaddam M, Frokiaer J, Nielsen S (2000) Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain. Biochem Biophys Res Commun 276:1118–1128 [PubMed: 11027599]

    Article  CAS  PubMed  Google Scholar 

  40. Elkjaer ML, Nejsum LN, Gresz V, Kwon TH, Jensen UB, Frokiaer J, Nielsen S (2001) Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways. Am J Physiol Ren Physiol 281:F1047–F1057 [PubMed: 11704555]

    Article  CAS  Google Scholar 

  41. Enger TB, Aure MH, Jensen JL, Galtung HK (2014) Calcium signaling and cell volume regulation are altered in Sjogren’s Syndrome. Acta Odontol Scand 72:549–556 [PubMed: 24471729]

    Article  CAS  PubMed  Google Scholar 

  42. Ferri D, Mazzone A, Liquori GE, Cassano G, Svelto M, Calamita G (2003) Ontogeny, distribution, and possible functional implications of an unusual aquaporin, AQP8, in mouse liver. Hepatology 38:947–957 [PubMed: 14512882]

    Article  CAS  PubMed  Google Scholar 

  43. Frigeri A, Gropper MA, Turck CW, Verkman AS (1995) Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci U S A 92:4328–4331 [PubMed: 7538665]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Fujita A, Horio Y, Nielsen S, Nagelhus EA, Hata F, Ottersen OP, Kurachi Y (1999) High-resolution immunogold cytochemistry indicates that AQP4 is concentrated along the basal membrane of parietal cell in rat stomach. FEBS Lett 459:305–309 [PubMed: 10526154]

    Article  CAS  PubMed  Google Scholar 

  45. Funaki H, Yamamoto T, Koyama Y, Kondo D, Yaoita E, Kawasaki K, Kobayashi H, Sawaguchi S, Abe H, Kihara I (1998) Localization and expression of AQP5 in cornea, serous salivary glands, and pulmonary epithelial cells. Am J Phys 275:C1151–C1157 [PubMed: 9755069]

    CAS  Google Scholar 

  46. Furuya S, Naruse S, Ko SB, Ishiguro H, Yoshikawa T, Hayakawa T (2002) Distribution of aquaporin 1 in the rat pancreatic duct system examined with light- and electron-microscopic immunohistochemistry. Cell Tissue Res 308:75–86 [PubMed: 12012207]

    Article  CAS  PubMed  Google Scholar 

  47. Garcia F, Kierbel A, Larocca MC, Gradilone SA, Splinter P, LaRusso NF, Marinelli RA (2001) The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP. J Biol Chem 276:12147–12152 [PubMed: 11278499]

    Article  CAS  PubMed  Google Scholar 

  48. Gradilone SA, Tietz PS, Splinter PL, Marinelli RA, LaRusso NF (2005) Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line WIF-B. BMC Physiol 5:13 [PubMed: 16109175]

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  49. Gregoire F, Lucidi V, Zerrad-Saadi A, Virreira M, Bolaky N, Delforge V, Lemmers A, Donckier V, Deviere J, Demetter P, Perret J, Delporte C (2015) Analysis of aquaporin expression in liver with a focus on hepatocytes. Histochem Cell Biol 144:347–363 [PubMed: 26126651]

    Article  CAS  PubMed  Google Scholar 

  50. Gresz V, Burghardt B, Ferguson CJ, Hurley PT, Takacs M, Nielsen S, Varga G, Zelles T, Case RM, Steward MC (1999) Expression of aquaporin 1 (AQP1) water channels in human labial salivary glands. Arch Oral Biol 44(Suppl 1):S53–S57 [PubMed: 10414857]

    CAS  PubMed  Google Scholar 

  51. Gresz V, Horvath A, Gera I, Nielsen S, Zelles T (2015) Immunolocalization of AQP5 in resting and stimulated normal labial glands and in Sjogren’s syndrome. Oral Dis 21:e114–e120 [PubMed: 24661359]

    Article  CAS  PubMed  Google Scholar 

  52. Groneberg DA, Gerber A, Fischer A (2001) Trafficking of lacrimal aquaporin-5 in Sjogren’s syndrome. Lancet 357:2054–2055 [PubMed: 11441861]

    Article  CAS  PubMed  Google Scholar 

  53. Hayakawa J, Mizukawa Y, Kurata M, Shiohara T (2013) A syringotropic variant of cutaneous sarcoidosis: presentation of 3 cases exhibiting defective sweating responses. J Am Acad Dermatol 68:1016–1021 [PubMed: 23374232]

    Article  PubMed  Google Scholar 

  54. He X, Tse CM, Donowitz M, Alper SL, Gabriel SE, Baum BJ (1997) Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflugers Arch Eur J Physiol 433:260–268 [PubMed: 9064641]

    Article  CAS  Google Scholar 

  55. Henquin JC, Nenquin M, Ravier MA, Szollosi A (2009) Shortcomings of current models of glucose-induced insulin secretion. Diabetes Obes Metab 11(Suppl 4):168–179 [PubMed: 19817799]

    Article  CAS  PubMed  Google Scholar 

  56. Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, Kishida K, Inoue K, Kuriyama H, Nakamura T, Fushiki T, Kihara S, Shimomura I (2005) Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc Natl Acad Sci U S A 102:10993–10998 [PubMed: 16009937]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Hill AE, Shachar-Hill B (2006) A new approach to epithelial isotonic fluid transport: an osmosensor feedback model. J Membr Biol 210:77–90 [PubMed: 16868677]

    Article  CAS  PubMed  Google Scholar 

  58. Huang Y, Tola VB, Fang P, Soybel DI, Van Hoek AN (2003) Partitioning of aquaporin-4 water channel mRNA and protein in gastric glands. Dig Dis Sci 48:2027–2036 [PubMed: 14627352]

    Article  CAS  PubMed  Google Scholar 

  59. Huang YH, Zhou XY, Wang HM, Xu H, Chen J, Lv NH (2013) Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells. Tumour Biol 34:1743–1751 [PubMed: 23436048]

    Article  CAS  PubMed  Google Scholar 

  60. Huebert RC, Splinter PL, Garcia F, Marinelli RA, LaRusso NF (2002) Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. J Biol Chem 277:22710–22717 [PubMed: 11932260]

    Article  CAS  PubMed  Google Scholar 

  61. Hurley PT, Ferguson CJ, Kwon TH, Andersen ML, Norman AG, Steward MC, Nielsen S, Case RM (2001) Expression and immunolocalization of aquaporin water channels in rat exocrine pancreas. Am J Physiol Gastrointest Liver Physiol 280:G701–G709 [PubMed: 11254497]

    CAS  PubMed  Google Scholar 

  62. Inoue N, Iida H, Yuan Z, Ishikawa Y, Ishida H (2003) Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands. J Dent Res 82:476–480 [PubMed: 12766202]

    Article  CAS  PubMed  Google Scholar 

  63. Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, Uchida S (2013) Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. J Dermatol Sci 70:26–33 [PubMed: 23473857]

    Article  CAS  PubMed  Google Scholar 

  64. Ishibashi K, Tanaka Y, Morishita Y (2014) The role of mammalian superaquaporins inside the cell. Biochim Biophys Acta 1840:1507–1512 [PubMed: 24189537]

    Article  CAS  PubMed  Google Scholar 

  65. Ishida N, Hirai SI, Mita S (1997) Immunolocalization of aquaporin homologs in mouse lacrimal glands. Biochem Biophys Res Commun 238:891–895 [PubMed: 9325187]

    Article  CAS  PubMed  Google Scholar 

  66. Ishikawa Y, Eguchi T, Skowronski MT, Ishida H (1998) Acetylcholine acts on M3 muscarinic receptors and induces the translocation of aquaporin5 water channel via cytosolic Ca2+ elevation in rat parotid glands. Biochem Biophys Res Commun 245:835–840 [PubMed: 9588201]

    Article  CAS  PubMed  Google Scholar 

  67. Ishikawa Y, Iida H, Ishida H (2002) The muscarinic acetylcholine receptor-stimulated increase in aquaporin-5 levels in the apical plasma membrane in rat parotid acinar cells is coupled with activation of nitric oxide/cGMP signal transduction. Mol Pharmacol 61:1423–1434 [PubMed: 12021404]

    Article  CAS  PubMed  Google Scholar 

  68. Isokpehi RD, Rajnarayanan RV, Jeffries CD, Oyeleye TO, Cohly HH (2009) Integrative sequence and tissue expression profiling of chicken and mammalian aquaporins. BMC Genet 10(Suppl 2):S7 [PubMed: 19607658]

    Article  CAS  Google Scholar 

  69. Itoh T, Rai T, Kuwahara M, Ko SB, Uchida S, Sasaki S, Ishibashi K (2005) Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochem Biophys Res Commun 330:832–838 [PubMed: 15809071]

    Article  CAS  PubMed  Google Scholar 

  70. Kabashima K, Shimauchi T, Kobayashi M, Fukamachi S, Kawakami C, Ogata M, Kabashima R, Mori T, Ota T, Fukushima S, Hara-Chikuma M, Tokura Y (2008) Aberrant aquaporin 5 expression in the sweat gland in aquagenic wrinkling of the palms. J Am Acad Dermatol 59(2 Suppl 1):S28–S32 [PubMed: 18625374]

    Article  PubMed  Google Scholar 

  71. King LS, Nielsen S, Agre P (1997) Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat. Am J Phys 273:C1541–C1548 [PubMed: 9374639]

    CAS  Google Scholar 

  72. Kirkegaard P, Lundberg JM, Poulsen SS, Olsen PS, Fahrenkrug J, Hokfelt T, Christiansen J (1981) Vasoactive intestinal polypeptidergic nerves and Brunner’s gland secretion in the rat. Gastroenterology 81:872–878 [PubMed: 6116642]

    CAS  PubMed  Google Scholar 

  73. Ko SB, Naruse S, Kitagawa M, Ishiguro H, Furuya S, Mizuno N, Wang Y, Yoshikawa T, Suzuki A, Shimano S, Hayakawa T (2002) Aquaporins in rat pancreatic interlobular ducts. Am J Physiol Gastrointest Liver Physiol 282:G324–G331 [PubMed: 11804854]

    Article  CAS  PubMed  Google Scholar 

  74. Koelz HR (1992) Gastric acid in vertebrates. Scand J Gastroenterol Suppl 193:2–6 [PubMed: 1290053]

    Article  CAS  PubMed  Google Scholar 

  75. Kondo H, Shimomura I, Kishida K, Kuriyama H, Makino Y, Nishizawa H, Matsuda M, Maeda N, Nagaretani H, Kihara S, Kurachi Y, Nakamura T, Funahashi T, Matsuzawa Y (2002) Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. Eur J Biochem 269:1814–1826 [PubMed: 11952783]

    Article  CAS  PubMed  Google Scholar 

  76. Konttinen YT, Tensing EK, Laine M, Porola P, Tornwall J, Hukkanen M (2005) Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjogren’s syndrome. J Rheumatol 32:1071–1075 [PubMed: 15940770]

    CAS  PubMed  Google Scholar 

  77. Konturek SJ, Zabielski R, Konturek JW, Czarnecki J (2003) Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion. Eur J Pharmacol 481:1–14 [PubMed: 14637169]

    Article  CAS  PubMed  Google Scholar 

  78. Koyama Y, Yamamoto T, Kondo D, Funaki H, Yaoita E, Kawasaki K, Sato N, Hatakeyama K, Kihara I (1997) Molecular cloning of a new aquaporin from rat pancreas and liver. J Biol Chem 272:30329–30333 [PubMed: 9374520]

    Article  CAS  PubMed  Google Scholar 

  79. Koyama Y, Yamamoto T, Tani T, Nihei K, Kondo D, Funaki H, Yaoita E, Kawasaki K, Sato N, Hatakeyama K, Kihara I (1999) Expression and localization of aquaporins in rat gastrointestinal tract. Am J Phys 276:C621–C627 [PubMed: 10069989]

    CAS  Google Scholar 

  80. Krane CM, Melvin JE, Nguyen HV, Richardson L, Towne JE, Doetschman T, Menon AG (2001) Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem 276:23413–23420 [PubMed: 11290736]

    Article  CAS  PubMed  Google Scholar 

  81. Kreda SM, Gynn MC, Fenstermacher DA, Boucher RC, Gabriel SE (2001) Expression and localization of epithelial aquaporins in the adult human lung. Am J Respir Cell Mol Biol 24:224–234 [PubMed: 11245621]

    Article  CAS  PubMed  Google Scholar 

  82. Laforenza U (2012) Water channel proteins in the gastrointestinal tract. Mol Asp Med 33:642–650 [PubMed: 22465691]

    Article  CAS  Google Scholar 

  83. Langerhans P (1869) Beiträge zur mikroscopischen anatomie der bauchspeichel druse. In: Inaugural-dissertation. Gustav Lange, Berlin

    Google Scholar 

  84. Larsen HS, Aure MH, Peters SB, Larsen M, Messelt EB, Kanli GH (2011) Localization of AQP5 during development of the mouse submandibular salivary gland. J Mol Histol 42:71–81 [PubMed: 21203896]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Lastraioli E, Iorio J, Arcangeli A (2015) Ion channel expression as promising cancer biomarker. Biochim Biophys Acta 1848:2685–2702 [PubMed: 25542783]

    Article  CAS  PubMed  Google Scholar 

  86. Lee BH, Gauna AE, Perez G, Park YJ, Pauley KM, Kawai T, Cha S (2013) Autoantibodies against muscarinic type 3 receptor in Sjogren’s syndrome inhibit aquaporin 5 trafficking. PLoS One 8:e53113 [PubMed: 23382834]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Lee MG, Ohana E, Park HW, Yang D, Muallem S (2012) Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev 92:39–74 [PubMed: 22298651]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Lehmann GL, Larocca MC, Soria LR, Marinelli RA (2008) Aquaporins: their role in cholestatic liver disease. World J Gastroenterol 14:7059–7067 [PubMed: 19084912]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Li J, Ha YM, Ku NY, Choi SY, Lee SJ, Oh SB, Kim JS, Lee JH, Lee EB, Song YW, Park K (2004) Inhibitory effects of autoantibodies on the muscarinic receptors in Sjogren’s syndrome. Lab Investig 84:1430–1438 [PubMed: 15448705]

    Article  CAS  PubMed  Google Scholar 

  90. Li J, Nielsen S, Dai Y, Lazowski KW, Christensen EI, Tabak LA, Baum BJ (1994) Examination of rat salivary glands for the presence of the aquaporin CHIP. Pflugers Arch Eur J Physiol 428:455–460 [PubMed: 7530838]

    Article  CAS  Google Scholar 

  91. Li L, Zhang H, Ma T, Verkman AS (2009) Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am J Physiol Gastrointest Liver Physiol 296:G816–G822 [PubMed: 19179619]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Lin X, Shaw PC, Sze SC, Tong Y, Zhang Y (2011) Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjogren’s syndrome mice. Int Immunopharmacol 11:2025–2032 [PubMed: 21890001]

    Article  CAS  PubMed  Google Scholar 

  93. Louchami K, Best L, Brown P, Virreira M, Hupkens E, Perret J, Devuyst O, Uchida S, Delporte C, Malaisse WJ, Beauwens R, Sener A (2012) A new role for aquaporin 7 in insulin secretion. Cell Physiol Biochem 29:65–74 [PubMed: 22415076]

    Article  CAS  PubMed  Google Scholar 

  94. Ma T, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS (2001) Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Phys Cell Phys 280:C126–C134 [PubMed: 11121384]

    CAS  Google Scholar 

  95. Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (1999) Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem 274:20071–20074 [PubMed: 10400615]

    Article  CAS  PubMed  Google Scholar 

  96. Maclaren OJ, Sneyd J, Crampin EJ (2013) What do aquaporin knockout studies tell us about fluid transport in epithelia? J Membr Biol 246:297–305 [PubMed: 23430220]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Maeda N (2012) Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome. Mol Asp Med 33:665–675 [PubMed: 22425521]

    Article  CAS  Google Scholar 

  98. Mailleux AA, Overholtzer M, Brugge JS (2008) Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle 7:57–62 [PubMed: 18196964]

    Article  CAS  PubMed  Google Scholar 

  99. Marinelli RA, LaRusso NF (1997) Aquaporin water channels in liver: their significance in bile formation. Hepatology 26:1081–1084 [PubMed: 9362345]

    Article  CAS  PubMed  Google Scholar 

  100. Marinelli RA, Lehmann GL, Soria LR, Marchissio MJ (2011) Hepatocyte aquaporins in bile formation and cholestasis. Front Biosci 16:2642–2652 [PubMed: 21622200]

    Article  CAS  Google Scholar 

  101. Matsuki-Fukushima M, Fujita-Yoshigaki J, Murakami M, Katsumata-Kato O, Yokoyama M, Sugiya H (2013) Involvement of AQP6 in the Mercury-sensitive osmotic lysis of rat parotid secretory granules. J Membr Biol 246:209–214 [PubMed: 23183829]

    Article  CAS  PubMed  Google Scholar 

  102. Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L (2007) Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol 27:6026–6037 [PubMed: 17576812]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Matsuzaki T, Ablimit A, Suzuki T, Aoki T, Hagiwara H, Takata K (2006) Changes of aquaporin 5-distribution during release and reaccumulation of secretory granules in isoproterenol-treated mouse parotid gland. J Electron Microsc 55:183–189 [PubMed: 16899467]

    Article  CAS  Google Scholar 

  104. Matsuzaki T, Machida N, Tajika Y, Ablimit A, Suzuki T, Aoki T, Hagiwara H, Takata K (2005) Expression and immunolocalization of water-channel aquaporins in the rat and mouse mammary gland. Histochem Cell Biol 123:501–512 [PubMed: 15844003]

    Article  CAS  PubMed  Google Scholar 

  105. Matsuzaki T, Suzuki T, Koyama H, Tanaka S, Takata K (1999) Aquaporin-5 (AQP5), a water channel protein, in the rat salivary and lacrimal glands: immunolocalization and effect of secretory stimulation. Cell Tissue Res 295:513–521 [PubMed: 10022971]

    Article  CAS  PubMed  Google Scholar 

  106. McManaman JL, Neville MC (2003) Mammary physiology and milk secretion. Adv Drug Deliv Rev 55:629–641 [PubMed: 12706546]

    Article  CAS  PubMed  Google Scholar 

  107. McManaman JL, Reyland ME, Thrower EC (2006) Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland. J Mammary Gland Biol Neoplasia 11:249–268 [PubMed: 17136613]

    Article  PubMed  Google Scholar 

  108. Mei WX, Lao SX, Yu N, Zhou Z, Huang LP, Hu B (2010) Relationship between gene expressions of aquaporin 3 and 4 and various degrees of spleen-stomach dampness-heat syndrome in chronic superficial gastritis. J Chin Integr Med 8:111–115 [PubMed: 20141731]

    Article  CAS  Google Scholar 

  109. Melvin JE, Yule D, Shuttleworth T, Begenisich T (2005) Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Annu Rev Physiol 67:445–469 [PubMed: 15709965]

    Article  CAS  PubMed  Google Scholar 

  110. Mendez-Gimenez L, Rodriguez A, Balaguer I, Fruhbeck G (2014) Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis. Mol Cell Endocrinol 397:78–92 [PubMed: 25008241]

    Article  CAS  PubMed  Google Scholar 

  111. Mennone A, Verkman AS, Boyer JL (2002) Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am J Physiol Gastrointest Liver Physiol 283:G739–G746 [PubMed: 12181190]

    Article  CAS  PubMed  Google Scholar 

  112. Miley HE, Sheader EA, Brown PD, Best L (1997) Glucose-induced swelling in rat pancreatic beta-cells. J Physiol 504:191–198 [PubMed: 9350629]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Miranda M, Ceperuelo-Mallafre V, Lecube A, Hernandez C, Chacon MR, Fort JM, Gallart L, Baena-Fustegueras JA, Simo R, Vendrell J (2009) Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalities. Metab Clin Exp 58:1762–1768 [PubMed: 19615702]

    Article  CAS  PubMed  Google Scholar 

  114. Misaka T, Abe K, Iwabuchi K, Kusakabe Y, Ichinose M, Miki K, Emori Y, Arai S (1996) A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach. FEBS Lett 381:208–212 [PubMed: 8601457]

    Article  CAS  PubMed  Google Scholar 

  115. Mobasheri A, Barrett-Jolley R (2014) Aquaporin water channels in the mammary gland: from physiology to pathophysiology and neoplasia. J Mammary Gland Biol Neoplasia 19:91–102 [PubMed: 24338153]

    Article  PubMed  Google Scholar 

  116. Mobasheri A, Kendall BH, Maxwell JE, Sawran AV, German AJ, Marples D, Luck MR, Royal MD (2011) Cellular localization of aquaporins along the secretory pathway of the lactating bovine mammary gland: an immunohistochemical study. Acta Histochem 113:137–149 [PubMed: 19853284]

    Article  CAS  PubMed  Google Scholar 

  117. Mobasheri A, Marples D (2004) Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology. Am J Phys Cell Phys 286:C529–C537 [PubMed: 14592814]

    Article  CAS  Google Scholar 

  118. Moore M, Ma T, Yang B, Verkman AS (2000) Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res 70:557–562 [PubMed: 10870513]

    Article  CAS  PubMed  Google Scholar 

  119. Morishita Y, Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K (2005) Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol 25:7770–7779 [PubMed: 16107722]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  120. Murdiastuti K, Miki O, Yao C, Parvin MN, Kosugi-Tanaka C, Akamatsu T, Kanamori N, Hosoi K (2002) Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats. Pflugers Arch Eur J Physiol 445:405–412 [PubMed: 12466944]

    Article  Google Scholar 

  121. Murdiastuti K, Purwanti N, Karabasil MR, Li X, Yao C, Akamatsu T, Kanamori N, Hosoi KA (2006) Naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands. Am J Physiol Gastrointest Liver Physiol 291:G1081–G1088 [PubMed: 16901987]

    Article  CAS  PubMed  Google Scholar 

  122. Nakamura M, Saga T, Watanabe K, Takahashi N, Tabira Y, Kusukawa J, Yamaki K (2013) An immunohistochemistry-based study on aquaporin (AQP)-1, 3, 4, 5 and 8 in the parotid glands, submandibular glands and sublingual glands of Sjogren’s syndrome mouse models chronically administered cevimeline. Kurume Med J 60(1):7–19 [PubMed: 23925155]

    Article  CAS  PubMed  Google Scholar 

  123. Nazemi S, Rahbek M, Parhamifar L, Moghimi SM, Babamoradi H, Mehrdana F, Klaerke DA, Knight CH (2014) Reciprocity in the developmental regulation of aquaporins 1, 3 and 5 during pregnancy and lactation in the rat. PLoS One 9:e106809 [PubMed: 25184686]

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  124. Nejsum LN, Kwon TH, Jensen UB, Fumagalli O, Frokiaer J, Krane CM, Menon AG, King LS, Agre PC, Nielsen S (2002) Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc Natl Acad Sci U S A 99:511–516 [PubMed: 11773623]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Nielsen S, King LS, Christensen BM, Agre P (1997) Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. Am J Phys 273:C1549–C1561 [PubMed: 9374640]

    CAS  Google Scholar 

  126. Nielsen S, Smith BL, Christensen EI, Agre P (1993) Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci U S A 90:7275–7279 [PubMed: 8346245]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  127. O’Connell AC, Baccaglini L, Fox PC, O’Connell BC, Kenshalo D, Oweisy H, Hoque AT, Sun D, Herscher LL, Braddon VR, Delporte C, Baum BJ (1999) Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates. Cancer Gene Ther 6:505–513 [PubMed: 10608347]

    Article  PubMed  Google Scholar 

  128. O’Hara SP, Tabibian JH, Splinter PL, LaRusso NF (2013) The dynamic biliary epithelia: molecules, pathways, and disease. J Hepatol 58:575–582 [PubMed: 23085249]

    Article  PubMed  Google Scholar 

  129. Okada S, Misaka T, Matsumoto I, Watanabe H, Abe K (2003) Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine. FEBS Lett 540:157–162 [PubMed: 12681500]

    Article  CAS  PubMed  Google Scholar 

  130. Parvin MN, Kurabuchi S, Murdiastuti K, Yao C, Kosugi-Tanaka C, Akamatsu T, Kanamori N, Hosoi K (2005) Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide in the Brunner’s gland of the rat duodenum. Am J Physiol Gastrointest Liver Physiol 288:G1283–G1291 [PubMed: 15650134]

    Article  CAS  PubMed  Google Scholar 

  131. Parvin MN, Tsumura K, Akamatsu T, Kanamori N, Hosoi K (2002) Expression and localization of AQP5 in the stomach and duodenum of the rat. Biochim Biophys Acta 1542:116–124 [PubMed: 11853885]

    Article  CAS  PubMed  Google Scholar 

  132. Poling HM, Mohanty SK, Tiao GM, Huppert SS (2014) A comprehensive analysis of aquaporin and secretory related gene expression in neonate and adult cholangiocytes. Gene Expr Patterns 15:96–103 [PubMed: 24929031]

    Google Scholar 

  133. Portincasa P, Palasciano G, Svelto M, Calamita G (2008) Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease. Eur J Clin Investig 38:1–10 [PubMed: 18173545]

    Article  CAS  Google Scholar 

  134. Prudente S, Flex E, Morini E, Turchi F, Capponi D, De Cosmo S, Tassi V, Guida V, Avogaro A, Folli F, Maiani F, Frittitta L, Dallapiccola B, Trischitta V (2007) A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. Diabetes 56:1468–1474 [PubMed: 17351148]

    Article  CAS  PubMed  Google Scholar 

  135. Raina S, Preston GM, Guggino WB, Agre P (1995) Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. J Biol Chem 270:1908–1912 [PubMed: 7530250]

    Article  CAS  PubMed  Google Scholar 

  136. Redman RS (1987) Development of salivary glands. In: Sreebny LM (ed) The salivary system. CRC Press, Boca Raton, pp 1–20

    Google Scholar 

  137. Ring T, Kallenbach M, Praetorius J, Nielsen S, Melgaard B (2006) Successful treatment of a patient with primary Sjogren’s syndrome with Rituximab. Clin Rheumatol 25(6):891–894 [PubMed: 16283417]

    Article  PubMed  Google Scholar 

  138. Rojek A, Fuchtbauer EM, Fuchtbauer A, Jelen S, Malmendal A, Fenton RA, Nielsen S (2013) Liver-specific Aquaporin 11 knockout mice show rapid vacuolization of the rough endoplasmic reticulum in periportal hepatocytes after amino acid feeding. Am J Physiol Gastrointest Liver Physiol 304:G501–G515 [PubMed: 23275615]

    Article  CAS  PubMed  Google Scholar 

  139. Rojek AM, Skowronski MT, Fuchtbauer EM, Fuchtbauer AC, Fenton RA, Agre P, Frokiaer J, Nielsen S (2007) Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci U S A 104:3609–3614 [PubMed: 17360690]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. Ruiz-Ederra J, Levin MH, Verkman AS (2009) In situ fluorescence measurement of tear film [Na+], [K+], [Cl-], and pH in mice shows marked hypertonicity in aquaporin-5 deficiency. Invest Ophthalmol Vis Sci 50:2132–2138 [PubMed: 19136711]

    Article  PubMed  PubMed Central  Google Scholar 

  141. Sasaki Y, Tsubota K, Kawedia JD, Menon AG, Yasui M (2007) The difference of aquaporin 5 distribution in acinar and ductal cells in lacrimal and parotid glands. Curr Eye Res 32:923–929 [PubMed: 18027168]

    Article  CAS  PubMed  Google Scholar 

  142. Sato K, Cavallin S, Sato KT, Sato F (1994) Secretion of ions and pharmacological responsiveness in the mouse paw sweat gland. Clin Sci 86:133–139 [PubMed: 8143423]

    Article  CAS  PubMed  Google Scholar 

  143. Satoh K, Narita T, Matsuki-Fukushima M, Okabayashi K, Ito T, Senpuku H, Sugiya H (2013) E2f1-deficient NOD/SCID mice have dry mouth due to a change of acinar/duct structure and the down-regulation of AQP5 in the salivary gland. Pflugers Arch Eur J Physiol 465:271–281 [PubMed: 23179381]

    Article  CAS  Google Scholar 

  144. Sener A, Malaisse WJ (2002) The stimulus-secretion coupling of amino acid-induced insulin release. Insulinotropic action of L-alanine. Biochim Biophys Acta 1573:100–104 [PubMed: 12383948]

    Article  CAS  PubMed  Google Scholar 

  145. Shan Z, Li J, Zheng C, Liu X, Fan Z, Zhang C, Goldsmith CM, Wellner RB, Baum BJ, Wang S (2005) Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol Ther 11:444–451 [PubMed: 15727941]

    Article  CAS  PubMed  Google Scholar 

  146. Shen L, Zhu Z, Huang Y, Shu Y, Sun M, Xu H, Zhang G, Guo R, Wei W, Wu W (2010) Expression profile of multiple aquaporins in human gastric carcinoma and its clinical significance. Biomed Pharmacother 64:313–318 [PubMed: 20106632]

    Article  CAS  PubMed  Google Scholar 

  147. Shen Y, Wang Y, Chen Z, Wang D, Wang X, Jin M, Bai C (2011) Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice. J Cell Mol Med 15:1355–1363 [PubMed: 20550619]

    Article  CAS  PubMed  Google Scholar 

  148. Shennan DB, Peaker M (2000) Transport of milk constituents by the mammary gland. Physiol Rev 80:925–951 [PubMed: 10893427]

    CAS  PubMed  Google Scholar 

  149. Skowronski MT, Lebeck J, Rojek A, Praetorius J, Fuchtbauer EM, Frokiaer J, Nielsen S (2007) AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. Am J Physiol Ren Physiol 292:F956–F965 [PubMed: 17077387]

    Article  CAS  Google Scholar 

  150. Smith JK, Siddiqui AA, Modica LA, Dykes R, Simmons C, Schmidt J, Krishnaswamy GA, Berk SL (1999) Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands. J Interf Cytokine Res 19:929–935 [PubMed: 10476940]

    Article  CAS  Google Scholar 

  151. Sneyd J, Crampin E, Yule D (2014) Multiscale modelling of saliva secretion. Math Biosci 257:69–79 [PubMed: 25014770]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Song Y, Sonawane N, Verkman AS (2002) Localization of aquaporin-5 in sweat glands and functional analysis using knockout mice. J Physiol 541:561–568 [PubMed: 12042359]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  153. Song Y, Verkman AS (2001) Aquaporin-5 dependent fluid secretion in airway submucosal glands. J Biol Chem 276(44):41288–41292 [PubMed: 11514581]

    Article  CAS  PubMed  Google Scholar 

  154. Soria LR, Fanelli E, Altamura N, Svelto M, Marinelli RA, Calamita G (2010) Aquaporin-8-facilitated mitochondrial ammonia transport. Biochem Biophys Res Commun 393:217–221 [PubMed: 20132793]

    Article  CAS  PubMed  Google Scholar 

  155. Soyfoo MS, De Vriese C, Debaix H, Martin-Martinez MD, Mathieu C, Devuyst O, Steinfeld SD, Delporte C (2007) Modified aquaporin 5 expression and distribution in submandibular glands from NOD mice displaying autoimmune exocrinopathy. Arthritis Rheum 56:2566–2574 [PubMed: 17665453]

    Article  CAS  PubMed  Google Scholar 

  156. Soyfoo MS, Konno A, Bolaky N, Oak JS, Fruman D, Nicaise C, Takiguchi M, Delporte C (2012) Link between inflammation and aquaporin-5 distribution in submandibular gland in Sjogren’s syndrome? Oral Dis 18:568–574 [PubMed: 22320885]

    Article  CAS  PubMed  Google Scholar 

  157. Splinter PL, Masyuk AI, NF LR (2003) Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs. J Biol Chem 278:6268–6274 [PubMed: 12468529]

    Article  CAS  PubMed  Google Scholar 

  158. Steinfeld S, Cogan E, King LS, Agre P, Kiss R, Delporte C (2001) Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjogren’s syndrome patients. Lab Investig 81:143–148 [PubMed: 11232635]

    Article  CAS  PubMed  Google Scholar 

  159. Takagi K, Yamaguchi K, Sakurai T, Asari T, Hashimoto K, Terakawa S (2003) Secretion of saliva in X-irradiated rat submandibular glands. Radiat Res 159:351–360 [PubMed: 12600238]

    Article  CAS  PubMed  Google Scholar 

  160. Talbot NC, Garrett WM, Caperna TJ (2003) Analysis of the expression of aquaporin-1 and aquaporin-9 in pig liver tissue: comparison with rat liver tissue. Cells Tissues Organs 174:117–128 [PubMed: 12835575]

    Article  CAS  PubMed  Google Scholar 

  161. Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I (2015) IP3R deficit underlies loss of salivary fluid secretion in Sjogren’s Syndrome. Sci Report 5:13953 [PubMed: 26365984]

    Article  CAS  Google Scholar 

  162. Tietz P, Jefferson J, Pagano R, Larusso NF (2005) Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion. J Lipid Res 46:1426–1432 [PubMed: 15834130]

    Article  CAS  PubMed  Google Scholar 

  163. Tietz PS, Marinelli RA, Chen XM, Huang B, Cohn J, Kole J, McNiven MA, Alper S, LaRusso NF (2003) Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. J Biol Chem 278:20413–20419 [PubMed: 12660234]

    Article  CAS  PubMed  Google Scholar 

  164. Tiwari S, Ali MJ, Vemuganti GK (2014) Human lacrimal gland regeneration: perspectives and review of literature. Saudi J Ophthalmol 28:12–18 [PubMed: 24526853]

    Article  PubMed  Google Scholar 

  165. Tradtrantip L, Tajima M, Li L, Verkman AS (2009) Aquaporin water channels in transepithelial fluid transport. J Med Investig 56(Suppl):179–184

    Article  Google Scholar 

  166. Tsubota K, Hirai S, King LS, Agre P, Ishida N (2001) Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren’s syndrome. Lancet 357:688–689 [PubMed: 11247557]

    Article  CAS  PubMed  Google Scholar 

  167. Turumin JL, Shanturov VA, Turumina HE (2013) The role of the gallbladder in humans. Rev Gastroenterol Mex 78:177–187 [PubMed: 23683886]

    CAS  PubMed  Google Scholar 

  168. Ueno Y, Alpini G, Yahagi K, Kanno N, Moritoki Y, Fukushima K, Glaser S, LeSage G, Shimosegawa T (2003) Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice. Liver Int 23(6):449–459 [PubMed: 14986819]

    Article  CAS  PubMed  Google Scholar 

  169. Verkman AS (2000) Physiological importance of aquaporins: lessons from knockout mice. Curr Opin Nephrol Hypertens 9:517–522 [PubMed: 10990371]

    Article  CAS  PubMed  Google Scholar 

  170. Verkman AS (2007) Role of aquaporins in lung liquid physiology. Respir Physiol Neurobiol 159:324–330 [PubMed: 17369110]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  171. Virreira M, Perret J, Delporte C (2011) Pancreatic beta-cells: role of glycerol and aquaglyceroporin 7. Int J Biochem Cell Biol 43:10–13 [PubMed: 21056684]

    Article  CAS  PubMed  Google Scholar 

  172. Wang D, Yuan Z, Inoue N, Cho G, Shono M, Ishikawa Y (2011) Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats. Biochim Biophys Acta 1810:543–554 [PubMed: 21295117]

    Article  CAS  PubMed  Google Scholar 

  173. Wang K, Feng YL, Wen FQ, Chen XR, Ou XM, Xu D, Yang J, Deng ZP (2007) Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease. Acta Pharmacol Sin 28:1166–1174 [PubMed: 17640479]

    Article  CAS  PubMed  Google Scholar 

  174. Wang KS, Komar AR, Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA (2000) Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol 279:G448–G453 [PubMed: 10915655]

    CAS  PubMed  PubMed Central  Google Scholar 

  175. Wellner RB, Redman RS, Swaim WD, Baum BJ (2006) Further evidence for AQP8 expression in the myoepithelium of rat submandibular and parotid glands. Pflugers Arch Eur J Physiol 451(5):642–645 [PubMed: 16311720]

    Article  CAS  Google Scholar 

  176. Yamamura Y, Aota K, Yamanoi T, Kani K, Takano H, Momota Y, Motegi K, Azuma M (2012b) DNA demethylating agent decitabine increases AQP5 expression and restores salivary function. J Dent Res 91:612–617 [PubMed: 22522773]

    Article  CAS  PubMed  Google Scholar 

  177. Yamamura Y, Motegi K, Kani K, Takano H, Momota Y, Aota K, Yamanoi T, Azuma M (2012a) TNF-alpha inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation. J Cell Mol Med 16:1766–1775 [PubMed: 21973049]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  178. Yang B, Song Y, Zhao D, Verkman AS (2005) Phenotype analysis of aquaporin-8 null mice. Am J Phys Cell Phys 288:C1161–C1170 [PubMed: 15647389]

    Article  CAS  Google Scholar 

  179. Yao C, Purwanti N, Karabasil MR, Azlina A, Javkhlan P, Hasegawa T, Akamatsu T, Hosoi T, Ozawa K, Hosoi K (2010) Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos. Am J Pathol 177:724–734 [PubMed: 20522648]

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  180. Young JA, Van Lennep EW (eds) (1978) The morphology of salivary glands. Academic Press, New York

    Google Scholar 

  181. Yoshimura S, Nakamura H, Horai Y, Nakajima H, Shiraishi H, Hayashi T, Takahashi T, Kawakami A (2015) Abnormal distribution of AQP5 in labial salivary glands is associated with poor saliva secretion in patients with Sjogren’s syndrome including neuromyelitis optica complicated patients. Modern Rheum:1–21 [PubMed: 26375433]

    Google Scholar 

  182. Yu D, Thelin WR, Randell SH, Boucher RC (2012) Expression profiles of aquaporins in rat conjunctiva, cornea, lacrimal gland and Meibomian gland. Exp Eye Res 103:22–32 [PubMed: 22828047]

    Article  CAS  PubMed  Google Scholar 

  183. Zhang M, Zeng S, Zhang L, Li H, Chen L, Zhang X, Li X, Lin C, Shu S, Xie S, He Y, Mao X, Peng L, Shi L, Yang L, Tang S, Fu X (2014) Localization of Na(+)-K(+)-ATPase alpha/beta, Na(+)-K(+)-2Cl-cotransporter 1 and aquaporin-5 in human eccrine sweat glands. Acta Histochem 116:1374–1381 [PubMed: 25218052]

    Article  CAS  PubMed  Google Scholar 

  184. Zhou Y, Wang Y, Wang S, Shen L (2015) Hyperglycemia Promotes Human Gastric Carcinoma Progression via Aquaporin 3. Dig Dis Sci 60:2338–2345 [PubMed: 25777259]

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by a Fund Doctor J.P. Naets from King Baudouin Foundation and a David & Alice Van Buuren Fund (Belgium). The author wishes to thank Prof. Jason Perret for helpful comments, discussion, and proofreading of the text.

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  1. Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium

    Christine Delporte Ph.D.

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  1. Christine Delporte Ph.D.
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Correspondence to Christine Delporte Ph.D. .

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  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Delporte, C. (2017). Aquaporins and Gland Secretion. In: Yang, B. (eds) Aquaporins. Advances in Experimental Medicine and Biology, vol 969. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1057-0_4

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