Abstract
Water transport through membrane is so intricate that there are still some debates. (Aquaporins) AQPs are entirely accepted to allow water transmembrane movement depending on osmotic gradient. Cotransporters and uniporters , however, are also concerned in water homeotatsis. Urea transporter B (UT-B) has a single-channel water permeability that is similar to AQP1. Cystic fibrosis transmembrane conductance regulator (CFTR ) was initially thought as a water channel but now not believed to transport water directly. By cotranporters, water is transported by water osmosis coupling with substrates, which explains how water is transported across the isolated small intestine. This chapter provides information about water transport mediated by other membrane proteins except AQPs .
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sands JM, Blount MA (2014) Genes and proteins of urea transporters. Subcell Biochem 73:45–63
Yang B, Verkman AS (2002) Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J Biol Chem 277(39):36782–36786
Ogami A, Miyazaki H, Niisato N, Sugimoto T, Marunaka Y (2006) UT-B1 urea transporter plays a noble role as active water transporter in C6 glial cells. Biochem Biophys Res Commun 351(3):619–624
Yang B, Verkman AS (1998) Urea transporter UT3 functions as an efficient water channel. Direct evidence for a common water/urea pathway. J Biol Chem 273(16):9369–9372
Yang B (2014) Transport characteristics of urea transporter-B. Subcell Biochem 73:127–135
Sidoux-Walter F, Lucien N, Olives B, Gobin R, Rousselet G, Kamsteeg EJ, Ripoche P, Deen PM, Cartron JP, Bailly P (1999) At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel. J Biol Chem 274(42):30228–30235
Azouzi S, Gueroult M, Ripoche P, Genetet S, Colin Aronovicz Y, Le Van Kim C, Etchebest C, Mouro-Chanteloup I (2013) Energetic and molecular water permeation mechanisms of the human red blood cell urea transporter B. PLoS One 8(12):e82338
Levin EJ, Quick M, Zhou M (2009) Crystal structure of a bacterial homologue of the kidney urea transporter. Nature 462(7274):757–761
Gadsby DC, Vergani P, Csanady L (2006) The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature 440(7083):477–483
Sheppard DN, Welsh MJ (1999) Structure and function of the CFTR chloride channel. Physiol Rev 79(1 Suppl):S23–S45
Poulsen JH, Fischer H, Illek B, Machen TE (1994) Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A 91(12):5340–5344
Shcheynikov N, Yang D, Wang Y, Zeng W, Karniski LP, So I, Wall SM, Muallem S (2008) The Slc26a4 transporter functions as an electroneutral Cl−/I−/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct. J Physiol 586(16):3813–3824
Hyde SC, Emsley P, Hartshorn MJ, Mimmack MM, Gileadi U, Pearce SR, Gallagher MP, Gill DR, Hubbard RE, Higgins CF (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346(6282):362–365
Schreiber R, Greger R, Nitschke R, Kunzelmann K (1997) Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes. Pflugers Arch 434(6):841–847
Hasegawa H, Skach W, Baker O, Calayag MC, Lingappa V, Verkman AS (1992) A multifunctional aqueous channel formed by CFTR. Science 258(5087):1477–1479
Schreiber R, Pavenstadt H, Greger R, Kunzelmann K (2000) Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator. FEBS Lett 475(3):291–295
Boj M, Chauvigne F, Cerda J (2015) Aquaporin biology of spermatogenesis and sperm physiology in mammals and teleosts. Biol Bull 229(1):93–108
Suzuki-Toyota F, Ishibashi K, Yuasa S (1999) Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis. Cell Tissue Res 295(2):279–285
Huang HF, He RH, Sun CC, Zhang Y, Meng QX, Ma YY (2006) Function of aquaporins in female and male reproductive systems. Hum Reprod Update 12(6):785–795
Jesus TT, Bernardino RL, Martins AD, Sa R, Sousa M, Alves MG, Oliveira PF (2014) Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells. Biochem Biophys Res Commun 446(4):1017–1021
Cheung KH, Leung CT, Leung GP, Wong PY (2003) Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis. Biol Reprod 68(5):1505–1510
Jesus TT, Bernardino RL, Martins AD, Sa R, Sousa M, Alves MG, Oliveira PF (2014) Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator. IUBMB Life 66(9):639–644
Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S (2008) Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem 283(5):2986–2996
Lauf PK, Adragna NC (2000) K-Cl cotransport: properties and molecular mechanism. Cell Physiol Biochem 10(5–6):341–354
Zeuthen T, MacAulay N (2002) Cotransporters as molecular water pumps. Int Rev Cytol 215:259–284
Ringel F, Plesnila N (2008) Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells. Neurosci Lett 442(3):219–223
Karadsheh MF, Byun N, Mount DB, Delpire E (2004) Localization of the KCC4 potassium-chloride cotransporter in the nervous system. Neuroscience 123(2):381–391
Zeuthen T (1991) Water permeability of ventricular cell membrane in choroid plexus epithelium from Necturus maculosus. J Physiol 444:133–151
Zeuthen T (1994) Cotransport of K+, Cl− and H2O by membrane proteins from choroid plexus epithelium of Necturus maculosus. J Physiol 478(Pt 2):203–219
Mollajew R, Zocher F, Horner A, Wiesner B, Klussmann E, Pohl P (2010) Routes of epithelial water flow: aquaporins versus cotransporters. Biophys J 99(11):3647–3656
Mercado A, Song L, Vazquez N, Mount DB, Gamba G (2000) Functional comparison of the K+−Cl− cotransporters KCC1 and KCC4. J Biol Chem 275(39):30326–30334
Plotkin MD, Kaplan MR, Peterson LN, Gullans SR, Hebert SC, Delpire E (1997) Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system. Am J Phys 272(1 Pt 1):C173–C183
Chen PY, Verkman AS (1988) Sodium-dependent chloride transport in basolateral membrane vesicles isolated from rabbit proximal tubule. Biochemistry 27(2):655–660
Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC (1994) Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269(26):17713–17722
Dunn JJ, Lytle C, Crook RB (2001) Immunolocalization of the Na-K-Cl cotransporter in bovine ciliary epithelium. Invest Ophthalmol Vis Sci 42(2):343–353
O'Donnell ME, Tran L, Lam TI, Liu XB, Anderson SE (2004) Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab 24(9):1046–1056
Hamann S, Herrera-Perez JJ, Bundgaard M, Alvarez-Leefmans FJ, Zeuthen T (2005) Water permeability of Na+−K+−2Cl- cotransporters in mammalian epithelial cells. J Physiol 568(Pt 1):123–135
Hamann S, Herrera-Perez JJ, Zeuthen T, Alvarez-Leefmans FJ (2010) Cotransport of water by the Na+−K+−2Cl(−) cotransporter NKCC1 in mammalian epithelial cells. J Physiol 588(Pt 21):4089–4101
Zeuthen T, Macaulay N (2012) Cotransport of water by Na(+)-K(+)-2Cl(−) cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2. J Physiol 590(5):1139–1154
Halestrap AP, Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343(Pt 2):281–299
Hamann S, Kiilgaard JF, la Cour M, Prause JU, Zeuthen T (2003) Cotransport of H+, lactate, and H2O in porcine retinal pigment epithelial cells. Exp Eye Res 76(4):493–504
Zeuthen T, Hamann S, la Cour M (1996) Cotransport of H+, lactate and H2O by membrane proteins in retinal pigment epithelium of bullfrog. J Physiol 497(Pt 1):3–17
Hamann S, la Cour M, Lui GM, Bundgaard M, Zeuthen T (2000) Transport of protons and lactate in cultured human fetal retinal pigment epithelial cells. Pflugers Arch 440(1):84–92
MacAulay N, Hamann S, Zeuthen T (2004) Water transport in the brain: role of cotransporters. Neuroscience 129(4):1031–1044
Loo DD, Hirayama BA, Meinild AK, Chandy G, Zeuthen T, Wright EM (1999) Passive water and ion transport by cotransporters. J Physiol 518(Pt 1):195–202
MacAulay N, Zeuthen T, Gether U (2002) Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1. J Physiol 544(Pt 2):447–458
Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW (1994) Localization of neuronal and glial glutamate transporters. Neuron 13(3):713–725
Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 14(9):5559–5569
MacAulay N, Gether U, Klaerke DA, Zeuthen T (2001) Water transport by the human Na+−coupled glutamate cotransporter expressed in Xenopus oocytes. J Physiol 530(Pt 3):367–378
Meinild A, Klaerke DA, Loo DD, Wright EM, Zeuthen T (1998) The human Na+−glucose cotransporter is a molecular water pump. J Physiol 508(Pt 1):15–21
Kwon HM, Yamauchi A, Uchida S, Preston AS, Garcia-Perez A, Burg MB, Handler JS (1992) Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein. J Biol Chem 267(9):6297–6301
Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (1998) Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. J Biol Chem 273(13):7501–7506
Dai G, Levy O, Carrasco N (1996) Cloning and characterization of the thyroid iodide transporter. Nature 379(6564):458–460
Tappenden KA (1999) The human Na+ glucose cotransporter is a molecular water pump. JPEN J Parenter Enteral Nutr 23(3):173–174
Loo DD, Zeuthen T, Chandy G, Wright EM (1996) Cotransport of water by the Na+/glucose cotransporter. Proc Natl Acad Sci U S A 93(23):13367–13370
Zeuthen T, Meinild AK, Loo DD, Wright EM, Klaerke DA (2001) Isotonic transport by the Na+−glucose cotransporter SGLT1 from humans and rabbit. J Physiol 531(Pt 3):631–644
Charron FM, Blanchard MG, Lapointe JY (2006) Intracellular hypertonicity is responsible for water flux associated with Na+/glucose cotransport. Biophys J 90(10):3546–3554
Zeuthen T, Zeuthen E (2007) The mechanism of water transport in Na+−coupled glucose transporters expressed in Xenopus oocytes. Biophys J 93(4):1413–1416 Discussion 1417–1419
Zeuthen T, Belhage B, Zeuthen E (2006) Water transport by Na+−coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substrate size studied at high resolution. J Physiol 570(Pt 3):485–499
Zeuthen T (2010) Water-transporting proteins. J Membr Biol 234(2):57–73
O'Neill MA, Ishii T, Albersheim P, Darvill AG (2004) Rhamnogalacturonan II: structure and function of a borate cross-linked cell wall pectic polysaccharide. Annu Rev Plant Biol 55:109–139
Groger N, Frohlich H, Maier H, Olbrich A, Kostin S, Braun T, Boettger T (2010) SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria. J Biol Chem 285(19):14467–14474
Parker MD, Ourmozdi EP, Tanner MJ (2001) Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney. Biochem Biophys Res Commun 282(5):1103–1109
Vilas GL, Loganathan SK, Liu J, Riau AK, Young JD, Mehta JS, Vithana EN, Casey JR (2013) Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases. Hum Mol Genet 22(22):4579–4590
Pajor AM (2006) Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch 451(5):597–605
Markovich D, Forgo J, Stange G, Biber J, Murer H (1993) Expression cloning of rat renal Na+/SO4(2−) cotransport. Proc Natl Acad Sci U S A 90(17):8073–8077
Wright EM (1985) Transport of carboxylic acids by renal membrane vesicles. Annu Rev Physiol 47:127–141
Meinild AK, Loo DD, Pajor AM, Zeuthen T, Wright EM (2000) Water transport by the renal Na(+)-dicarboxylate cotransporter. Am J Physiol Ren Physiol 278(5):F777–F783
Pajor AM, Sun NN (2010) Single nucleotide polymorphisms in the human Na+−dicarboxylate cotransporter affect transport activity and protein expression. Am J Physiol Ren Physiol 299(4):F704–F711
Olson AL, Pessin JE (1996) Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu Rev Nutr 16:235–256
Fischbarg J, Kuang KY, Hirsch J, Lecuona S, Rogozinski L, Silverstein SC, Loike J (1989) Evidence that the glucose transporter serves as a water channel in J774 macrophages. Proc Natl Acad Sci U S A 86(21):8397–8401
Fischbarg J, Kuang KY, Vera JC, Arant S, Silverstein SC, Loike J, Rosen OM (1990) Glucose transporters serve as water channels. Proc Natl Acad Sci U S A 87(8):3244–3247
Dempster JA, van Hoek AN, de Jong MD, van Os CH (1991) Glucose transporters do not serve as water channels in renal and intestinal epithelia. Pflugers Arch 419(3–4):249–255
Zeuthen T, Zeuthen E, Macaulay N (2007) Water transport by GLUT2 expressed in Xenopus laevis oocytes. J Physiol 579(Pt 2):345–361
Salas-Burgos A, Iserovich P, Zuniga F, Vera JC, Fischbarg J (2004) Predicting the three-dimensional structure of the human facilitative glucose transporter glut1 by a novel evolutionary homology strategy: insights on the molecular mechanism of substrate migration, and binding sites for glucose and inhibitory molecules. Biophys J 87(5):2990–2999
Zeuthen T, Stein WD (1994) Cotransport of salt and water in membrane proteins: membrane proteins as osmotic engines. J Membr Biol 137(3):179–195
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Huang, B., Wang, H., Yang, B. (2017). Water Transport Mediated by Other Membrane Proteins. In: Yang, B. (eds) Aquaporins. Advances in Experimental Medicine and Biology, vol 969. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1057-0_17
Download citation
DOI: https://doi.org/10.1007/978-94-024-1057-0_17
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-024-1055-6
Online ISBN: 978-94-024-1057-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)