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Identification of Volatile Organic Compound Biomarkers Associated with Gastric Cancer Cells and Their Ultrasensitive Electrochemical Detection

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Gastric Cancer Prewarning and Early Diagnosis System

Part of the book series: Translational Medicine Research ((TRAMERE))

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Abstract

To look for gastric cancer cell volatile organic compound biomarkers is helpful to develop simple fast diagnosis method for gastric cancer. This chapter summarizes eight volatile organic compound biomarkers that were recognized from gastric cancer MGC803 cells and normal gastric mucous GES-1 cells. The MCNTs covered with Au-Ag nanocomposites were used as a sensing film and an ultrasensitive electrochemical detection system was established. Identified VOCs associated with gastric cancer cells and established electrochemical assay systems have great potential in applications such as early diagnosis and prognosis of gastric cancer.

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Abbreviations

CNTs:

Carbon nanotubes

GC/MS:

Gas chromatography/mass spectrometer

GCE:

Glass carbon electrode

MWNTs:

Multiwalled carbon nanotubes

SPME:

Headspace solid-phase microextraction

VOCs:

Volatile organic compounds

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Authors and Affiliations

  1. Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China

    Yixia Zhang & Daxiang Cui

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  1. Yixia Zhang
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  2. Daxiang Cui
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Correspondence to Yixia Zhang .

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Editors and Affiliations

  1. Institute of Nano Biomedicine and Engineering, Shanghai Jiao Tong University, Shanghai, China

    Daxiang Cui

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Zhang, Y., Cui, D. (2017). Identification of Volatile Organic Compound Biomarkers Associated with Gastric Cancer Cells and Their Ultrasensitive Electrochemical Detection. In: Cui, D. (eds) Gastric Cancer Prewarning and Early Diagnosis System. Translational Medicine Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-0951-2_6

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