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Regulation of Interleukin-12 Production in Antigen-Presenting Cells

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Book cover Regulation of Cytokine Gene Expression in Immunity and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 941))

Abstract

Interleukin-12 is a heterodimeric cytokine produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells, during encountering with intracellular microbes. IL-12 plays a key role in the activation of natural killer cells and CD4+ T helper cells in both innate and adaptive immune responses against infectious agents and immunosurveillance against endogenous malignancies. However, the potency of IL-12 makes it a target for stringent regulation. Indeed, the temporal, spatial, and quantitative expression of IL-12 during an immune response in a microenvironment contributes critically to the determination of the type, extent, and ultimate resolution of the reaction. Breaching of the delicate control and balance involving IL-12 frequently leads to autoimmune inflammatory disorders and pathogenesis. Thus, a better understanding of the regulatory mechanisms in the production and control of this cytokine is both scientifically significant and clinically beneficial. Here we provide an update on the research that has been conducted on this subject particularly in the last 10 years since the publication of a major thesis of this nature.

The authors declare no conflict of interest.

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  1. State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, China

    Hua Zheng, Fang Wei & Xiaojing Ma

  2. Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA

    Yi Ban & Xiaojing Ma

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  1. Hua Zheng
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    Xiaojing Ma

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Zheng, H., Ban, Y., Wei, F., Ma, X. (2016). Regulation of Interleukin-12 Production in Antigen-Presenting Cells. In: Ma, X. (eds) Regulation of Cytokine Gene Expression in Immunity and Diseases. Advances in Experimental Medicine and Biology, vol 941. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-0921-5_6

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