Advancements in Life Sciences and Characteristic Features of Cancer Cells

  • Kyu-Won Kim
  • Jae Kyung Roh
  • Hee-Jun Wee
  • Chan Kim


Advances in modern life sciences have primarily focused on cellular research because of the “Cell Theory” (Schleiden and Schwann 1838), which defines the cell as the basic unit of all organisms. Since cells are the common structural unit of a variety of organisms including animals and plants, it was hypothesized that complex life phenomena of multicellular organisms could be understood by studying individual cells. Molecular-level research began in 1953, when the double helix structure of DNA—the genetic material that transmits cellular characteristics to the next generation—was elucidated by Watson and Crick. Subsequently, advances in the understanding of the functions and mechanisms of cells were made rapidly.


Cancer Cell Vascular Endothelial Growth Factor Telomere Length Aerobic Glycolysis Tumor Blood Vessel 
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  1. 1.
    Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674CrossRefPubMedGoogle Scholar
  2. 2.
    Luca AD, Maiello MR et al (2012) The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets 2:17–27CrossRefGoogle Scholar
  3. 3.
    Kleinsmith LJ (2005) Principles of cancer biology. Pearson, San FranciscoGoogle Scholar
  4. 4.
    Li W, Giancott FG (2010) Merlin’s tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4(DCAF1). Cell Cycle 9:4433–4436CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Kang MH, Reynolds CP (2009) Bcl-2 Inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 15:1126–1132CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Mu J, Wei LX (2002) Telomere and telomerase in oncology. Cell Res 12:1–7CrossRefPubMedGoogle Scholar
  7. 7.
    Murnane JP (2010) Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res 70:4255–4259CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Vander Heiden MG, Cantley LC, Thompson CB (2010) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029–1033CrossRefGoogle Scholar
  9. 9.
    Balkwill FR, Capasso M, Hagemann T (2012) The tumor microenvironment at a glance. J Cell Sci 125:5591–5596CrossRefPubMedGoogle Scholar
  10. 10.
    Dudley AC (2012) Tumor endothelial cells. Cold Spring Harb Perspect Med 2(3):a006536Google Scholar
  11. 11.
    Sundar SS, Ganesan TS (2007) Role of lymphangiogenesis in cancer. J Clin Oncol 25:4298–4307CrossRefPubMedGoogle Scholar
  12. 12.
    Mantovani A et al (2008) Cancer-related inflammation. Nature 454:436–444CrossRefPubMedGoogle Scholar
  13. 13.
    Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6:392–401CrossRefPubMedGoogle Scholar
  14. 14.
    Pardal R, Clarke MF, Morrison SJ (2003) Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3:895–902CrossRefPubMedGoogle Scholar
  15. 15.
    Weis SM, Cheresh DA (2011) Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med 17:1359–1370CrossRefPubMedGoogle Scholar
  16. 16.
    Grothey A, Galanis E (2009) Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol 6:507–518CrossRefPubMedGoogle Scholar
  17. 17.
    Zhang YW, Su Y, Volpert OV, Vande Woude GF (2003) Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin-1 regulation. Proc Natl Acad Sci U S A 100:12718–12723CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    de la Puente P, Muz B, Azab F et al (2013) Cell trafficking of endothelial progenitor cells in tumor progression. Clin Cancer Res 19:3360–3368CrossRefPubMedGoogle Scholar
  19. 19.
    Alberts B, Johnson A, Lewis J et al (2002) Molecular biology of the cell. 4th ed. Garland Science, New YorkGoogle Scholar
  20. 20.
    Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420–1428CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4:71–78Google Scholar
  22. 22.
    Goldman B, DeFrancesco L (2009) The cancer vaccine roller coaster. Nat Biotechnol 27:129–139CrossRefPubMedGoogle Scholar
  23. 23.
    Gyrd-Hansen M, Meier P (2010) IAPs: from caspase inhibitors to modulators of NF-kappa B, inflammation and cancer. Nat Rev Cancer 10:561–574CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Kyu-Won Kim
    • 1
  • Jae Kyung Roh
    • 2
  • Hee-Jun Wee
    • 1
  • Chan Kim
    • 3
  1. 1.College of PharmacySeoul National UniversitySeoulKorea (Republic of)
  2. 2.Department of Internal MedicineYonsei University College of MedicineSeoulKorea (Republic of)
  3. 3.Department of Internal MedicineCHA Bundang Medical CenterSeongnamKorea (Republic of)

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