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Recent Advances on the Modular Organization of the Cortex pp 157–179Cite as

Prefrontal Cortical Microcircuits for Executive Control of Behavior

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Abstract

During the perception-to-action cycle, our cerebral cortex mediates the interactions between the environment and the perceptual-executive systems of the brain. At the top of the executive hierarchy, prefrontal cortical microcircuits are assumed to bind perceptual and executive control information to guide goal-driven behavior. Here, we discuss new results that show the involvement of prefrontal cortical inter-laminar microcircuits in the executive control of behavior. Recent results show that during perception and executive selection phases, cell firing in the localized prefrontal layers and caudate-putamen region exhibited a similar location preference on spatial-trials, but less on object- trials. When the perceptual-executive microcircuit became facilitated by electrically micro-stimulating the prefrontal infra-granular-cell layers with signal patterns previously derived from neuron firing in the supra-granular-layers, it was shown to produce stimulation-induced spatial preference (similar to neural tuning) in the percent correct performance only during spatial trials. These results suggested that inter-laminar prefrontal microcircuits play causal roles to the executive control of behavior across the perception-to-action cycle.

Keywords

  • Cortical microcircuits
  • Executive control
  • Minicolumn
  • Prefrontal cortex
  • Primates
  • MIMO model
  • Causal relationship
  • Perception-to-action

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC, 27103, USA

    Ioan Opris Ph.D.

  2. Department of Cognitive Science, University of Vienna, Vienna, Austria

    Ioana L. Popa

  3. Department of Psychiatry, University of Louisville, Louisville, KY, USA

    Manuel F. Casanova M.D.

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  1. Ioan Opris Ph.D.
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  2. Ioana L. Popa
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  3. Manuel F. Casanova M.D.
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Corresponding author

Correspondence to Ioan Opris Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Louisville, Louisville, Kentucky, USA

    Manuel F. Casanova

  2. Dept. of Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

    Ioan Opris

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Opris, I., Popa, I.L., Casanova, M.F. (2015). Prefrontal Cortical Microcircuits for Executive Control of Behavior. In: Casanova, M., Opris, I. (eds) Recent Advances on the Modular Organization of the Cortex. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9900-3_10

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