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FOXP3+ Treg Cells and Systems Biology Approaches to Studying Their Function

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Single Cell Sequencing and Systems Immunology

Part of the book series: Translational Bioinformatics ((TRBIO,volume 5))

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Abstract

Regulatory T (Treg) cells play a key role in immunological homeostasis in health and disease. The molecular mechanisms underlying the differentiation, maintenance and function of Treg cells remains largely unclear. However, recent studies have shown that Treg development is not simply controlled by a series of linear signaling pathways, but rather a complex and dynamic regulatory network. This section provides an overview of the applications of systems biological tools in the Treg field. These approaches have brought to the field new insights into the complexities of Treg biology.

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Authors and Affiliations

  1. Unit of Molecular Immunology, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 411 Hefei Road, Shanghai, 200025, China

    Xuerui Luo B.S., Andy Tsun, Jing Yang B.S., Zuojia Chen Ph.D., Yayi Gao Ph.D., Kongchen Li M.S., Miranda Piccioni Ph.D. & Bin Li Ph.D.

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  1. Xuerui Luo B.S.
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  2. Andy Tsun
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  3. Jing Yang B.S.
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  4. Zuojia Chen Ph.D.
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  5. Yayi Gao Ph.D.
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  7. Miranda Piccioni Ph.D.
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  8. Bin Li Ph.D.
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Correspondence to Miranda Piccioni Ph.D. or Bin Li Ph.D. .

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  1. Zhongshan Hospital Fudan University, Shanghai, China

    Xiangdong Wang

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Luo, X. et al. (2015). FOXP3+ Treg Cells and Systems Biology Approaches to Studying Their Function. In: Wang, X. (eds) Single Cell Sequencing and Systems Immunology. Translational Bioinformatics, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9753-5_6

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