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Chromokinesins in Genome Maintenance and Cancer

  • Manjari MazumdarEmail author
  • Tom Misteli
Chapter

Abstract

The chromokinesins constitute a distinct and unique subfamily of kinesin motor proteins. Chromokinesins are predominantly nuclear and localize to condensed chromosome arms during mitosis. Although chromokinesins are generally thought to primarily be involved in production of polar ejection forces to push chromosomes away from the pole for metaphase alignment, more recent studies have revealed some chromokinesins as integral components of chromosome structure. The two major family members, chromokinesins 4 and 10, possess unique properties and perform critical functions, including chromatin organization during both interphase and mitosis. Interestingly, chromokinesins studies have also been implicated in a number of human cancers. In this chapter we review the current knowledge of the structure, function and potential role of chromokinesins in cancer as well as the promise of this class of kinesins as candidate targets for therapeutic strategies.

Keywords

Mitotic Chromosome Motor Domain Histone Chaperone Kinesin Motor Maintain Genome Stability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.HoustonUSA
  2. 2.National Cancer Institute, NIHBethesdaUSA

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