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Kinesin-13 Microtubule Depolymerizing Proteins as Targets for Cancer Therapy

  • Anutosh Ganguly
  • Fernando CabralEmail author
Chapter

Abstract

The success of drugs that target mitotic spindle microtubules to treat cancer has spurred an interest in identifying other spindle proteins as potential drug targets that may be similarly effective yet have fewer side effects. The known activities of kinesin-13 family members to promote spindle bipolarity and faithful chromosome segregation, along with their ability to influence microtubule behavior, suggest that these proteins would be particularly effective targets for drug development. This chapter reviews the activities of kinesin-13 proteins in the context of how they might be manipulated to affect spindle structure and advance cancer treatment by direct targeting, by enhancing the effectiveness of other current treatments, or by reversing resistance to other treatments.

Keywords

Vinca Alkaloid Spindle Pole Microtubule Inhibitor Microtubule Attachment Tongue Squamous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Department of Microbiology and Infectious DiseasesSnyder Institute, University of CalgaryCalgaryCanada
  2. 2.Department of Integrative Biology and PharmacologyUniversity of Texas Medical SchoolHoustonUSA

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