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The Human Kinesin-14 Motor KifC1/HSET Is an Attractive Anti-cancer Drug Target

  • Vaishali Pannu
  • Padmashree C. G. Rida
  • Ritu AnejaEmail author
Chapter

Abstract

KifC1/HSET is a kinesin-14 motor protein recently recognized as a crucial player in the bi-focal clustering of supernumerary centrosomes in human cancer cells during mitosis. Various threads of evidence also implicate HSET as a potential driver of tumor evolution, with overexpression resulting in the emergence of more aggressive traits in tumors. Since HSET function appears to be dispensable for the viability of healthy somatic cells, these observations raise the tantalizing possibility that targeting HSET might be a promising cancer-selective chemotherapeutic approach. In this chapter, we summarize the multiple cellular roles played by HSET in various model systems and enumerate the steps required to validate and develop HSET as an anti-cancer drug target.

Keywords

Spindle Pole Spindle Assembly Bipolar Spindle Centrosome Amplification Central Spindle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Vaishali Pannu
    • 1
  • Padmashree C. G. Rida
    • 1
  • Ritu Aneja
    • 1
    Email author
  1. 1.Department of BiologyGeorgia State UniversityAtlantaUSA

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