Kif15: A Useful Target for Anti-cancer Therapy?
Kif15 (kinesin-12) was discovered a decade ago as a kinesin motor involved in bipolar spindle assembly. Although its exact molecular function is still under debate, data from recent studies indicate that Kif15 cooperates with Eg5 (kinesin-5) to promote centrosome separation and bipolar spindle assembly. Due to the essential function of Eg5 in bipolar spindle assembly, inhibitors of this protein recently entered clinical trails as anti-cancer therapy. However, several studies from past years indicate that Eg5 is not essential for bipolar spindle assembly under certain conditions and Kif15 seems to the central player in mediating Eg5-independent bipolar spindle assembly. In this chapter, we describe the function of Kif15 during mitosis and discuss if Kif15 could be a target for drug development in anticancer therapy.
KeywordsSpindle Assembly Bipolar Spindle Nuclear Envelope Breakdown Monopolar Spindle Centrosome Separation
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