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Clinical Trials of Mitotic Kinesin Inhibitors

  • Steven S. RosenfeldEmail author
Chapter

Abstract

Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

Keywords

Multiple Myeloma Small Molecule Inhibitor Vinca Alkaloid Synthetic Lethality High Mitotic Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Department of Cancer Biology and Rose Ella Burkhardt Brain Tumor CenterCleveland Clinic FoundationClevelandUSA

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