Future Directions in Hydrogen Studies

  • Xiao Chen
  • Xuejun Sun
  • Shigeo OhtaEmail author


Although the biological effect of hydrogen was first reported in 1975, it did not draw much attention. Since the protective effects of small amount of hydrogen on oxidative stress were revealed in 2007, recent years have witnessed a tremendous development of hydrogen biology. Hydrogen has been proved effective in various diseases including ischemia/reperfusion injuries, diabetes, pancreatitis, ulcerative colitis, and so on. However, the underlying mechanism is still not clear. Neutralizing toxic oxygen species only explains part of the phenomena and is now being challenged by increasingly accumulated evidence. The future direction for hydrogen biology lies in molecular mechanism, clinical study, and in other biological systems. Besides, some other small molecules like helium and methane are worth exploring.


Hydrogen Development Biological effects Future direction 


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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Department of Orthopedics trauma, Shanghai Changhai HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.Department of Navy AeromedicineSecond Military Medical UniversityShanghaiChina
  3. 3.Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of MedicineNippon Medical SchoolKawasakiJapan

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