Skip to main content

Prosexual Effects of Lycium Barbarum

  • Chapter
  • First Online:
Book cover Lycium Barbarum and Human Health

Abstract

Lycium barbarum, also known as wolfberry, has been commonly used as an oriental herb in China for a long period. Wolfberry is suggested to be antiaging and used to maintain health of kidneys, liver, and the eyes. In the practice of traditional Chinese medicine, wolfberry was also prescribed for patients who suffered from dysfunctions of sexual desire. Although it has been put into application for a long history, the underlying mechanism is still elusive. In the past decades, increasing lines of evidence support the roles of wolfberry in promoting male sexual functioning. The benefit of wolfberry was shown on different aspects including preventing the reproductive tissues from oxidative insult, improving motility of sperm, maintaining a testosterone level, and promoting sexual performance of the hemicastrated rats. This chapter discusses on the recent research findings, both from bench and bedside, which support the prosexual function of wolfberry, and discusses the potential clinical application of wolfberry on the treatment of sexual behavior.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Reference

  • Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) juice, GoChi. J Altern Complement Med. 2008;14:403–12. doi:10.1089/acm.2008.0004.

    Article  PubMed  Google Scholar 

  • Amagase H, Sun B, Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr Res. 2009;29:19–25. doi:10.1016/j.nutres.2008.11.005.

    Article  CAS  PubMed  Google Scholar 

  • Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483–95. doi:10.1016/j.cell.2005.02.001.

    Article  CAS  PubMed  Google Scholar 

  • Bonde JP. Male reproductive organs are at risk from environmental hazards. Asian J Androl. 2010;12:152–6. doi:10.1038/aja.2009.83.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Chao S-L, Huang L-W, Yen H-R. Pregnancy in premature ovarian failure after therapy using Chinese herbal medicine. Chang Gung Med J. 2003;26:449–52.

    PubMed  Google Scholar 

  • Clément C, Witschi U, Kreuzer M. The potential influence of plant-based feed supplements on sperm quantity and quality in livestock: a review. Anim Reprod Sci. 2012;132:1–10. doi:10.1016/j.anireprosci.2012.04.002.

    Article  PubMed  Google Scholar 

  • Feng Z, Jia H, Li X, Bai Z, Liu Z, Sun L, Zhu Z, Bucheli P, Ballèvre O, Wang J, Liu J. A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro. Neurochem Res. 2010;35:702–11. doi:10.1007/s11064-010-0123-5.

    Article  CAS  PubMed  Google Scholar 

  • Hasegawa M, Wilson G, Russell LD, Meistrich ML. Radiation-induced cell death in the mouse testis: relationship to apoptosis. Radiat Res. 1997;147:457–67.

    Article  CAS  PubMed  Google Scholar 

  • Huang J, Li Q, Zhao R, Li W, Han Z, Chen X, Xiao B, Wu S, Jiang Z, Hu J, Liu L. Effect of sugars on maturation rate of vitrified-thawed immature porcine oocytes. Anim Reprod Sci. 2008;106:25–35. doi:10.1016/j.anireprosci.2007.03.023.

    Article  CAS  PubMed  Google Scholar 

  • Lau BW-M, Yau S-Y, So K-F. Reproduction: a new venue for studying function of adult neurogenesis? Cell Transplant. 2011;20:21–35. doi:10.3727/096368910X532765.

    Article  PubMed  Google Scholar 

  • Lau BW-M, Lee JC-D, Li Y, Fung SM-Y, Sang Y-H, Shen J, Chang RC-C, So K-F. Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PLoS One. 2012;7:e33374. doi:10.1371/journal.pone.0033374.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Leuner B, Glasper ER, Gould E. Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormones. PLoS One. 2010;5:e11597. doi:10.1371/journal.pone.0011597.

    Article  PubMed Central  PubMed  Google Scholar 

  • Li Y-J, Song T-B, Cai Y-Y, Zhou J-S., Song X, Zhao X, Wu X-L. Bisphenol A exposure induces apoptosis and upregulation of Fas/FasL and caspase-3 expression in the testes of mice. Toxicol Sci. 2009;108:427–36. doi:10.1093/toxsci/kfp024.

    Article  CAS  PubMed  Google Scholar 

  • Luo Q, Li Z, Huang X, Yan J, Zhang S, Cai Y-Z. Lycium barbarum polysaccharides: protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life Sci. 2006;79:613–21. doi:10.1016/j.lfs.2006.02.012.

    Article  CAS  PubMed  Google Scholar 

  • Luo Q, Cui X, Yan J, Yang M, Liu J, Jiang Y, Li J, Zhou Y. Antagonistic effects of Lycium barbarum polysaccharides on the impaired reproductive system of male rats induced by local subchronic exposure to 60Co-γ irradiation. Phytother Res. 2011;25:694–701. doi:10.1002/ptr.3314.

    Article  CAS  PubMed  Google Scholar 

  • Luo Q, Li J, Cui X, Yan J, Zhao Q, Xiang C. The effect of Lycium barbarum polysaccharides on the male rats’ reproductive system and spermatogenic cell apoptosis exposed to low-dose ionizing irradiation. J Ethnopharmacol. 2014;154(1):249–58. doi:10.1016/j.jep.2014.04.013.

    Article  CAS  PubMed  Google Scholar 

  • Mathur PP, D’Cruz SC. The effect of environmental contaminants on testicular function. Asian J Androl. 2011;13:585–91. doi:10.1038/aja.2011.40.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004;56:185–229. doi:10.1124/pr.56.2.6.

    Article  CAS  PubMed  Google Scholar 

  • Podlipna D, Cichna-Markl M. Determination of bisphenol A in canned fish by sol—gel immunoaffinity chromatography, HPLC and fluorescence detection. Eur Food Res Technol. 2006;224:629–34. doi:10.1007/s00217-006-0350-9.

    Article  Google Scholar 

  • Sohn DW, Kim HY, Kim SD, Lee EJ, Kim HS, Kim JK, Hwang SY, Cho Y-H, Kim SW. Elevation of intracavernous pressure and NO-cGMP activity by a new herbal formula in penile tissues of spontaneous hypertensive male rats. J. Ethnopharmacol. 2008;120:176–80. doi:10.1016/j.jep.2008.08.005.

    Article  PubMed  Google Scholar 

  • Suzuki M, Osawa S, Hirano M. A Lycium chinense miller component inducing ovulation in adult female rabbits. Tohoku J Exp Med. 1972;106:219–31.

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Zhao H, Sheng X, Gambino PE, Costello B, Bojanowski K. Protective effect of Fructus Lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium. J Ethnopharmacol. 2002;82:169–75.

    Article  CAS  PubMed  Google Scholar 

  • Xiao S, Diao H, Smith MA, Song X, Ye X. Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice. Reprod Toxicol. 2011;32:434–41. doi:10.1016/j.reprotox.2011.08.010.

    PubMed Central  PubMed  Google Scholar 

  • Xin Y-F, You Z-Q, Gao H, Zhou G-L, Chen Y-X, Yu J, Xuan Y-X. Protective effect of Lycium barbarum polysaccharides against doxorubicin-induced testicular toxicity in rats. Phytother Res. 2012;26:716–21. doi:10.1002/ptr.3633.

    Article  CAS  PubMed  Google Scholar 

  • Zhang C, Wang A, Sun X, Li X, Zhao X, Li S, Ma A. Protective effects of Lycium barbarum polysaccharides on testis spermatogenic injury Induced by bisphenol A in mice. Evid Based Complement Altern Med. 2013;2013:690808. doi:10.1155/2013/690808.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Benson Wui-Man Lau .

Editor information

Editors and Affiliations

Conclusion

Conclusion

Apart from protecting the DNA and alleviating the reproductive tissue damage due to hypothermia, oxidative stress, and radiation, the fruit also protects testis from damage by environment pollutant like BPA. Female fertility is also restored by a herbal medicine containing wolfberry. The fruit also shows protective effect to the cognitive function of offspring with prenatal stress. Different pieces of evidence have shown that L. barbarum would be an all-round aphrodisiac agent that not only improves the sexual function of male individual and the fertility of female, but also the general health of both male and female. These beneficial effects imply L. barbarum would be a potent functional food. Nevertheless, the drug interaction between the fruit and common drugs, especially drugs for chronic diseases, still need to be clarified, in order to utilize wolfberry as an adjunctive therapy for sexual dysfunctions. Yet, further studies may be needed to determine the therapeutic dosage of wolfberry as the quality control of the fruit and the active components are still being elusive.

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Lau, BM., Leung, MP., Po, KT., Chang, RC., So, KF. (2015). Prosexual Effects of Lycium Barbarum . In: Chang, RC., So, KF. (eds) Lycium Barbarum and Human Health. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9658-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-9658-3_8

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-9657-6

  • Online ISBN: 978-94-017-9658-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics