Surgical Treatments for Anorexia Nervosa

  • Bomin SunEmail author
  • Dianyou Li
  • Wei Liu
  • Shikun Zhan
  • Yixin Pan
  • Xiaoxiao Zhang


Anorexia nervosa (AN) is a severe psychiatric disorder with high rates of morbidity and mortality. An estimated 21 % of patients experience a chronic course despite treatment with the best available medications and behavioral therapies. Existing data suggest that lesioning and deep brain stimulation can benefit a large proportion (ranging from 60 to 80 %) of patients with medically intractable AN. Long-term serious adverse events are very infrequent. Functional neuroimaging studies have increased our understanding of the mechanisms of disease development and therapeutic action. At our institution, we grade AN on a four-point scale based on patient clinical characteristics and our surgical experience over the past 8 years. This scale is particularly useful for guiding the selection of surgical procedures. Such treatment options include deep brain stimulation or lesioning of the nucleus accumbens , anterior capsulotomy, and anterior cingulotomy. Data suggest that surgical treatment is a viable option for intractable AN, and can alleviate suffering and improve the quality of life of patients with these disabling disorders.


Anorexia nervosa Surgery Deep brain stimulation Capsulotomy Cingulotomy 


Conflict of Interest Statement

The authors declare that there are no conflicts of interest.


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Copyright information

© Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Bomin Sun
    • 1
    Email author
  • Dianyou Li
    • 1
  • Wei Liu
    • 1
  • Shikun Zhan
    • 1
  • Yixin Pan
    • 1
  • Xiaoxiao Zhang
    • 1
  1. 1.Department of Stereotactic and Functional NeurosurgeryRuijin Hospital, Shanghai Jiaotong University School of MedicineShanghaiChina

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