Abstract
DNA origami is the science of folding DNA molecules to make novel two and three dimensional shapes. The science of folding of DNA into pre-decided shapes was started by Paul Rothemund at California Institute of Technology. Rothemund explored a number of ways by which 7000 base pair viral genome could be folded into three dimensional shapes. He ordered DNA staples from a synthesis company, added them to the hybridization mixture and allowed sing stranded DNA to fold along the path of staples. The result was a smiley face visualized using atomic force microscopy. A number of novel inventions have come up in the recent years, inspired by Rothmund’s work. More complex three dimensional shapes like drug-delivery nanocages, alphabets and numbers have been developed by self-folding DNA.
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Joshi, M., Kundapura, S., Poovaiah, T., Dhar, P. (2015). DNA Origami: What, How and Where. In: Singh, V., Dhar, P. (eds) Systems and Synthetic Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9514-2_19
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DOI: https://doi.org/10.1007/978-94-017-9514-2_19
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