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The Biology and Functions of Th22 Cells

Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 841)

Abstract

T helper (Th) cells develop from naïve CD4+ T cells under lineage-specific culture conditions and are nominated by their lineage-specific cytokines. Th22 cells, new players in adoptive immune responses, are identified by the production of interleukin (IL)-22. Plenty of observations are obtained over the past few years indicating that IL-22 is produced by activated T cells including Th22 cells, Th17 cells, Th1 cells, innate lymphoid cells and some nonlymphocytes. IL-22 functions synergistically with IL-17 or tumor necrosis factor (TNF), however, it plays different roles by IL-22/IL-22 receptor signal transductions in pathologic processes, including inflammations, autoimmunity, tumor, and digestive organs damages. In this chapter, we focus on the biology of IL-22, the generation and regulation of Th22 cells, the possible signal pathways that involved in the functions of Th22 cells, as well as the relationship between Th22 cells and various diseases.

Keywords

IL-22 STAT Th22 cell Disease 

Abbreviations

TNF

Tumor necrosis factor

IL-TIF

IL-10-related-T-cell-derived inducible factor

DC

Dendritic cell

ILC

Innate lymphoid cell

LTi cell

Lymphoid tissue inducer cell

NCR

Natural cytotoxicity triggering receptor

IL-22 BP

IL-22 binding protein

AHR

Aryl hydrocarbon receptor

CCR

Chemokine receptor

CCL

Chemokine ligand

SIRT

Sirtuin

ROR

Retinoic acid receptor-related orphan receptor

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© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Key Laboratory of Tropical Disease Control Research of Ministry of Education, Zhongshan School of Medicine, Institute of ImmunologySun Yat-Sen UniversityGuangzhouChina

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