Advertisement

Mouse Skin Transplantation

  • Weihua GongEmail author
Chapter

Abstract

Mouse nonvascularized skin transplant model is used to investigate the immunological mechanisms of graft chronic/acute rejection and mainly characterized by its easy surgical procedure compared with other vascularized transplant models. Importantly, skin graft rejecting process is reliable and reproducible in the aspect of allogeneic responses, offering its wide use in the field of murine transplant researches. Skin grafting has become a basic and established operation technique, applicable to other small lab animals such as guinea pigs and rabbits.

Keywords

Skin Graft Tissue Adhesive Skin Allograft Donor Skin Skin Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Baldwin 3rd WM, Cohen N, Hrapchak BB. Prolonged survival of murine skin grafted across a weak histocompatibility barrier as a function of skin-grafting technique. Transplantation. 1973;15(4):419–22.PubMedCrossRefGoogle Scholar
  2. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature. 1953;172(4379):603–6.PubMedCrossRefGoogle Scholar
  3. Brown DM, Barton BR, Young VL, Pruitt BA. Decreased wound contraction with fibrin glue–treated skin grafts. Arch Surg. 1992;127(4):404–6.PubMedCrossRefGoogle Scholar
  4. Garrod KR, Cahalan MD. Murine skin transplantation. J Vis Exp. 2008;11:e634.Google Scholar
  5. Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, Austyn JM. Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med. 1990;172(5):1483–93.PubMedCrossRefGoogle Scholar
  6. Li QY, Chi YY, Liu SQ. Cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models. Immunopharmacol Immunotoxicol. 2008;30(2):365–81.PubMedCrossRefGoogle Scholar
  7. Matsuo S, Kurisaki A, Sugino H, Hashimoto I, Nakanishi H. Analysis of skin graft survival using green fluorescent protein transgenic mice. J Med Invest. 2007;54(3–4):267–75.PubMedCrossRefGoogle Scholar
  8. Schwoebel F, Barsig J, Wendel A, Hamacher J. Quantitative assessment of mouse skin transplant rejection using digital photography. Lab Anim. 2005;39(2):209–14.PubMedCrossRefGoogle Scholar
  9. Sugarbaker PH, Chang AE. Uncovered skin grafts in mice. J Immunol Methods. 1979;31(1–2):167–75.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.Department of SurgeryThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouPeople’s Republic of China

Personalised recommendations