Abstract
Large amounts of literature and long-term clinical practice have confirmed that Danshen offers protection over myocardial ischemia and reperfusion injury as a kind of traditional Chinese medicine to promote blood circulation and remove blood stasis. Moreover, it can also inhibit myocardial cell hypertrophy, prevent cardiac arrhythmia, and treat viral myocarditis. Danshen is clinically used for the protection of cardiac muscle and as an adjunctive therapy for pneumocardial disease during operations on the heart. Danshen can directly relax the coronary artery muscle muscle , and thus it can be clinically applied to the treatment of coronary heart disease and can improve microcirculation by promoting blood circulation , removing blood stasis, and inhibiting blood clotting, can reduce the viscosity of blood and significantly improve the hyperviscosity of blood, and finally inhibit thrombogenesis. Danshen can inhibit the proliferation and migration of vascular smooth muscle cells, protect the functions of blood vessel endothelium, and indirectly exert its regulatory functions through the inhibitory effects of the “dangerous risks” of hypertension, and its injection can be used for the treatment of acute hypertensive cerebral hemorrhage. The pharmacological action of Danshen on cardiovascular system diseases and its mechanisms will be discussed in full scale in this chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sun J, Huang SH, Tan BK, et al. Life Sci. 2005;76(24):2849.
Chen SL, Wu XH, Wang XD. Chin Med Res Clin. 2005;3(5):13.
Yan XJ, Wu TF. Tianjin Pharm. 1992;4(4):22.
Zhang J, Zeng XR, Yang Y, et al. J Luzhou Med Coll. 2000;23(3):177.
Liu QG, Wang L, Lu ZY, et al. Chin J Hosp Pharm. 1999;19(11):653.
Liu QG, Sun YM, Cheng YZ, et al. China J Mod Med. 2005;5(8):2257.
Liu QG, Sun YM, Cheng YZ, et al. Chin Pharmacol Bull. 2005;21(9):1078.
Zhang ZX, Ren CL, Chen SX, et al. J Jiangsu Univ (Med Ed). 2003;13(5):391.
Su XH, Wang XM. Chin J Pathophysiol. 1996;12(2):186.
Tang LH, Wang XM, Liang DQ. Chin J Pathophysiol. 1989;5(2):65.
Fan YC, Zhan GF, Zhang WZ. J Tianjin Univ Tradit Chin Med. 2004;23(1):12.
Jiang HP, Wu YT, Chen JG. Chin J Microcirc. 2006;16(1):40.
Ke SS, Zhao ZD. Tianjin Med. 1996;24(12):715.
Ke YH, Qu SB. J Beijing Coll Acupuncture-Moxibustion. 2001;8(1):17.
Zhang DF, Ruan CW, Liu ZM, et al. Shanghai Med J. 2003;26(9):669.
Xie H, Zheng Z. Chin J Hypertens. 2004;12(4):359.
Lu WF, Xia Q, Zhang X. Chin Tradit Herbal Drugs. 1998;(29):460.
Wang R, Chen LB, Zeng XR. J Shandong Univ. 2005;43(4):280.
Wang GJ. J Jinzhou Med Coll. 2003;24(1):47.
Tang ZZ, Tang Y. J Fourth Mil Med Univ. 2004;24(2):100.
Feng J, Li SS. Chin J Hypertens. 2005;13(8):488.
Chen BH, Gong LY, Xu W, et al. Chin J Prim Med Pharm. 2005;12(7):775.
Zhan CY, Tao XL, Han SJ, et al. Chin J Clin Rehabil. 2005;9(23):243.
Zhan CY, Tao XL, Tian C, et al. Chin Clin Rehabil. 2005;9(19):254.
Sun LP, Zheng Z. Pract Geriatr. 2004;18(1):25.
Liu F, Zheng Z, Zhong Q. Chin J Pract Chin W Med. 2004;4(17):1096.
Guo ZQ, Wang SR, Zhu LQ, et al. Chin J Integr Med. 2005;25(4):342.
Maki T, Kawahara Y, Tanonaka K, et al. Planta Med. 2002;68(12):1103.
Zhu LM, Zeng XT. Shandong Med J. 2005;15(20):22.
Zhao YW, Xie WL, Sun WJ, et al. Acta Acad Med CPAF. 2005;14(4):256.
Yu HB, Xu CQ, Shan HL, et al. J Harbin Med Univ. 2002;36(2):112.
Cheng GZ, Hu XH, Li Y. Jilin J Tradit Chin Med. 2000;20(4):17.
An XF. Tianjin Med J. 1997;25(8):502.
van der Wal AC, Das PK, Tigges AJ, et al. Am J Pathol. 1992;141(1):161.
Meng ZX, Zhu FX, Han CL, et al. J Cardiovasc Pulm Dis. 1995;14(2):101.
Wang P, Zhang Y, Fan YM, et al. J Cardiovasc Pulm Dis. 1996;15(1):52.
Tian JY, Chen JZ, Gu Y, et al. Chin J Clin Rehabil. 2000;9(8):1708.
Sun XM. Chin Tradit Herbal Drugs. 1991;22(1):22.
Han F, Xie ML, Zhu LJ, et al. Chin J New Drugs Clin Remedies. 2002;21(7):389.
Jiang CC, Cai HH, Fan LM, et al. Acta Univ Med Nanjing. 1994;14(4):522.
Qin PS, Fan LJ, Liu KY, et al. Chin Tradit Pat Med. 2000;22(9):630.
Sun L, Dai PS, Shao J, et al. Tianjin J Tradit Chin Med. 2000;17(3):61.
Li L. Chin J Geriatr. 2003;22(11):706.
Liu J, Zhang HJ. Tianjin Pharm. 2003;15(3):38.
Whorton AR, Montgomery ME, Kent RS. J Clin Invest. 1985;76(1):295.
Lin RX, Liu GP, Zhao LC. J Guangzhou Univ Tradit Chin Med. 1997;14(4):288.
Lin Q, et al. Chin J Basic Med Tradit Chin Med. 2001;7(5):54.
Liu H. Hubei J Tradit Chin Med. 2001;23(8):11.
Lin Q, Lu JG. Shanxi J Tradit Chin Med. 2002;18(4):56.
Yu GY, Deng ZD, Qu ZL. Chin J Pathol. 1998;27:174.
Chen TZ, Lai JK. Chin J Pathol. 1989;18:15.
Xu DB, Zhang JP, Zhang WZ, et al. J Tianjin Med Univ. 2001;7(1):21.
Wang XX. Chin J Pharmacol Toxicol. 1993;7(2):157.
Stringer MD, Görög PG, Freeman A, et al. BMJ. 1989;298(6669):281.
Wu YJ, Hong CY, Lin SJ, et al. Arterioscler Thromb Vasc Biol. 1998;18(3):481.
Wu L, et al. Chin J Gerontol. 1996;16(4):239.
Wu WP. Beijing Med J. 1995;17(3):133.
Wang N, Cai HJ, Zhu Y, et al. Acta Uni Med Nanjing. 1994;14(4):529.
Zhang L, Wang XM, Zhao BL, et al. J Harbin Med Univ. 1992;26(4):255.
Zhao Y, Jiang W, Hou JW, et al. Acta Biochimica et Biophysica Sinica. 1995;27(6):610.
Xie HL, Gu ZL, Qian ZN, et al. Chin J Mod Appl Pharm. 1992;9(1):1.
Pryor WA, Squadrito GL. Am J Physiol. 1995;268(5Pt l):L699.
Liao LF, Zhou X. Chin J Mod Appl Pharm. 2002;4(2):132.
Raines EW, Ross R. BrHeart J. 1993;69(1 Suppl):S30.
Kuzuya M, Kuzuya F. Free Radic Biol Med. 1993;14(1):67.
Anderson TJ, Gerhard MD, Meredith IT, et al. Am J Cardiol. 1995;75(6):71B.
Cai HJ, editor. Basis and clinical investigations on artherosclerosis. JiangSu Science and Technology Press; 1996. p. 102.
Ross R. N Engl J Med. 1986;314(8):488.
Collins P, Fox K. Eul Heart J. 1992;13(4):560.
Xie HL, Gu ZL, Zhu LJ, et al. Chin Tradit Herbal Drugs. 2001;32(7):1007.
Shi YF. Chin J Cardiovasc Rehabil Med. 2002;11(6):226.
Xu JL, Wang XM, Wang DX. Chin J Pathophysiol. 2005;21(8):1659.
Lao J, Gu YD. Chin J Surg. 1993;9(1):39.
Jiang Z, Liu HX. Chin J Intern Med. 1997;36(11):778.
Zhang YY. Chin J Pathophysiol. 1998;14(6):626.
Li WQ, Xie MZ, Wei P, et al. Shanxi J Tradit Chin Med. 2000;16(4):25.
Feng PF, Qin NP, Qin YG, et al. Chin J Integr Med. 1999;19(5):286.
Luo WB, Wang YP. Acta Pharmacol Sin. 2001;22(12):1134.
Xie ML, Lu Q, Zhu LJ, et al. J Chin Med Mater. 2000;23(8):474.
Zhang YJ, Zhang FY, Fan YC. Tianjin J Tradit Chin Med. 2005;22(4):328.
Zu SY, Gao YM, Zhu GJ. Chin J Geriatr Heart Brain Vessel Dis. 2004;6(4):257.
Finkelstein JD. Eur J Pediatr. 1998;157(Suppl 2):S40.
Boushey CJ, Beresford SA, Omenn GS, et al. Probable benefits of increasing folic acid intakes. JAMA. 1995;274(13):1049.
Huang RX, Su ZP. Cerebral apoplexy. Beijing: The People’s Health Press; 2001. p. 48.
Bo QL. Chin Pharmacol Bull. 2003;7(24):3286.
Ross R. Transplant Proc. 1993;25(2):2041.
Plow EF, D’Souza SE. Circulation. 1997;95(6):1355.
Entwistle J, Hail CL, Turley EA. J Cell Biochem. 1996;61(4):569.
Zhang M, Wen JK, Sun HC, et al. Chin J Pathophysiol. 2004;20(10):1871.
Jiang KY, Gu ZL, Ruan CG. Chin Pharmacol Bull. 2000;16(6):682.
Stampfer MJ, Malinow MR, Willett WC, et al. JAMA. 1992;268(7):877.
Yuan XL, Hai CX, Liang X, et al. Chin J Clin Rehabil. 2003;7(24):3281.
Zhang XC. Chin J Arterioscler. 1999;7(4):179.
Chen JZ, Tian JY, Gu Y. Chin J Clin Rehabil. 2004;8(24):5048.
Xu T, Yu L, Zheng Z. J Clin Cardiol. 2005;21(1):54.
Jiang KY, Ruan CG, Gu ZL, et al. Acta Pharmacol Sin. 1998;19(1):47.
Wang L, Huang X, Ding ZH, et al. West China J Pharm Sci. 1995;10(4):193.
Cheng SW. Hunan Guiding J Tradit Chin Med Pharmacol. 2003;9(7):66.
Zhou HD, Ju YF. Sichuan Med J. 1997;18(3):177.
Wang H, Gao XM, Zhang BL. Tianjin J Tradit Chin Med. 2004;21(3):231.
Ma XQ, Shi D. Chin J Gen Surg. 2002;11(8):488.
Zhang WJ, Bao XF, Wang XF. Chin J Arterioscler. 1999;4(1):45.
Wang H, Gao XM, Zhang BL, et al. Chin Pharm J. 2005;40(2):106.
Du XH, Yang FJ, Wang WM. J Chin Med Mater. 2003;26(9):647.
Wang W, Xu ZP, Lui HY. J Tianjin Coll Tradit Chin Med. 2003;22(2):23.
Yang HP. J Hengyang Med Coll. 1991;19:123.
Sun BH, Zhang WR, Che DY. Acta Univ Med Tongji. 1995;24(1):51.
Du JR. West China J Pharm Sci. 1999;14(1):11.
Zhou XM, Lu ZY, Wang DW. Chin J Integr Med. 1996;16(8):480.
Wu HM, Yin WH. Acta Univ Med Tongji. 2001;30(2):106.
Chen ZW, Ma CG, Fang M, et al. Acta Pharm Sin. 1994;29(1):15.
Ge SR. J Chin Med Mater. 2002;25(9):683.
Shi Y, Wen JK. J Cardiovasc Pulm Dis. 1999;18(3):216.
Zu ZW, Xu LN, Tian JY, et al. Acta Pharm Sin. 1993;28(4):241.
Wu ZZ, Ni Z, Xu HQ, et al. J Nanjing Univ Tradit Chin Med. 1995;11(6):35.
Gu YH, Zhang CY, Huang GQ, et al. J Shanghai Second Med Univ. 1990;10(3):208.
Gu YH, Zhang CY, Huang GQ, et al. Chin J Hematol. 1993;14(10):540.
Zhu P, et al. Chin J Clin Thorac Cardiovasc Surg. 1989;5(2):103.
Chen SH, et al. J Biol Chem. 1988;4(1):88.
Parmley WW, Blurnlein S, Sievers R. Am J Cardiol. 1985;55(3):165B.
Henry PD, Bentley KI. J Clin Invest. 1981;68(5):1366.
Mu YF, et al. Chin J Gerontol. 1987;4:256.
Stein O, Leitersdorf E, Stein Y. Arteriosclerosis. 1985;5(1):35.
Qin SC, et al. Chin J Gerontol. 1989;9(supplement):19.
Sun XM, et al. Chin J Integr Med. 1989;9(10):804.
Wang MJ. Chin J Synthetical Med. 2006;7(3):234.
Chen SL, Wu XH, Wang XD. Chin Med Invest Clin Invest. 2005;3(5):13.
Zhuge LM, Wu Q, Lou ZJ. J Zhejiang Tradit Chin Med Coll. 2005;29(4):13.
Nie GL, Guo MJ, Li YP, et al. Chin Geraeology J. 2007;27(9):823.
Li FJ. Mod J Integr Tradit Chin W Med. 2006;15(20):2803.
Wu JH, Yang SY, Jin LD, et al. J Shanghai Med Univ. 1998;25(1):47.
Li DM, Li HF, Li W, et al. J Gansu Coll Tradit Chin Med. 2000;17(12):15.
Yin J, editor. Modern investigations and clinical applications of traditional Chinese medicine. Beijing: Xueyuan Publishing House; 1993. p. 174.
Yokozawa T, Lee Tw, Chung HY, et al. J Pharm Pharmacol. 1990;42(10):712.
Yokozawa T, Lee Tw, Oura H, et al. Nephron. 1992;60(4):460.
Kamata K, Iizuka T, Nagai M, et al. GeFt Pharmacol. 1993;24(4):977.
Gao XP, Xu DY, Deng YL, et al. Chin J Tradit Chin Med. 2004;29(4):359.
Xu F, Lu BG, Yao Z, et al. Chin Crit Care Med. 1996;8(5):262.
Fang KF, Yang YX, Gong NS, et al. Chin J Integr Med Cardio-/Cerebrovasc Dis. 2004;2(3):133.
Che DY, Zhang WR. Acta Univ Med Tongji. 1994;23(2):81.
Yang Y, Deng CS. Hubei J Tradit Chin Med. 1999;21(6):284.
Cheng JY, Lu ZQ, Li ZP, et al. Chin J Clin Pharmacol Ther. 2004;9(7):807.
Wu YS, Gao XF, Yang JH, et al. Chin J Integr Tradit W Med Intensive Crit Care. 1998;5(2):69.
Huang W. Mod J Integr Tradit Chin W Med. 2004;13(20):2702.
Yu JG, Yu ZR. J Nantong Med. 2000;20(2):172.
Tang XX, Chen XL. Guangxi Med J. 2004;26(2):251.
Liu H, Zheng ZE, Huang X. J Chin Mod Med. 2005;2(6):511.
Li JX, Mi JP, Zhao SQ, et al. J Tradit Chin Med. 2007;22(9):57.
Yu CL, Yao XQ. Chin J Integr Med Cardio-/Cerebrovasc Dis. 2007;5(6):478.
Kim DD, Sanchez FA, Duran RG, et al. Am J Physiol Heart Circ Physiol. 2007;292(5):H2131.
Lu YJ, Zhou M. Chin J Integr Med Cardio-/Cerebrovasc Dis. 2007;5(4):291.
Zhan CY, Tao XL, Zhou SX, et al. Chin Pharm J. 2006;41(17):1309.
Zhou Y, Gu J, Xu LM. J Chin Integr Med. 2007;5(1):61.
Hu SX. Pract J Card Cereb Pneumal Vasc Dis. 2006;14(9):697.
Zou P, Wang XY. J Guiyang Coll Tradit Chin Med. 2007;29(5):25.
Yang Y, Wang SX, Ma SY, et al. Jilin J Tradit Chin Med. 2006;26(5):37.
Xu DB, Zhang JP, Zhang WZ, et al. J Tianjin Med Univ. 2001;7(1):21.
Ge YX, Duan YY, Ruan LT, et al. Chin J Clin Rehabililation. 2004;8(6):1096.
Yang LR, Xu XY, Chen G. Pharmacol Clin Chin Mater Med. 2004;20(2):7.
Ren DC, Du GH, Zhang JT. Jpn J Pharmacol. 2002;90(4):276.
Ju G, Chen WL, Dong X. J China-Japan Friendship Hosp. 2005;19(4):230.
Ren DC, Du GH, Zhang JT. Chin J Pharmacol Toxical. 2003;17(5):333.
Ren DC, Du GH, Zhang JT. Chin Med J. 2003;116(4):630.
Lin GY, Wang ZJ. Shaanxi J Tradit Chin Med. 2007;28(6):647.
Lin L, Zheng YF, Qu JH, et al. Acta Acad Med Sin. 2001;23(4):386.
Hua SM, Guan GY, Jin H, et al. Chin J Clin Pharmacol Ther. 2000;5(4):363.
Hung HH, Chen YL, Lin SJ, et al. HistoI Histopathol. 2001;16(1):175.
Li X, Du JR, Zhang R, et al. China J Chin Mater Med. 2004;29(3):255.
Sun Y, Gao YM, Zhu GJ. Basic Clin Med. 2003;23(6):634.
Li YS, Wang ZH, et al. Chin J Crit Care Med. 2007;27(8):720.
Li YS, Gong ZH, Liang QS, et al. Chin J Hypertens. 2006;14(11):882.
Zhang XG, Yu ZH, Wen SY. Chin Pharm J. 2006;41(16):1276.
Wei LS. Med J Nat Defending Forces Southwest China. 2006;16(6):596.
Li YJ, Du GH. Chin Pharm J. 2003;88(11):844.
Wang H, Gao XM, Zhang BL, et al. Tianjin J Tradit Chin Med. 2004;21(3):281.
Chen P, Xu XJ. Chin J Integr Tradit W Med Intensive Crit Care. 2007;14(5):813.
Li XR, Li YP, Deng XL, et al. Chin J Clin Rehabil. 2006;10(31):55.
Li PF, Dietz R, von Harsdorf R. FEBS Lett. 1997;404(2–3):249.
Du XH, Xiang H, Yu LS, et al. J Chin Med Mater. 2004;27(9):659.
Zhou XX, Wen JK, Han M. Chin J Biochem Mol Biol. 1999;15(6):997.
Liu HB, Wen JK, Han M. Chin J Arterioscler. 2001;9(1):10.
Liu HB, Wen JK, Han M. Chin J Gerontol. 2001;3(21):22.
Liu HB, Wen JK, Han M. Chin J Integr Med. 2002;22(10):764.
Shi Y, Wen JK. J Cardiovasc Pulm Dis. 1999;18(3):216.
Zhao GC, et al. Chin J Pathophysiol. 1987;3(4).
Tang LH, et al. Chin J Pathophysiol. 1989;5(2).
Sun DD, et al. J Harbin Med Univ. 1986;(2):6.
Han C, et al. Chin J Pathophysiol. 1991;7(4):337.
Chang YZ, et al. Chin J Pathophysiol. 1991;7(5).
Su XH, et al. Chin J Pathophysiol. 1992;8(2):122.
Tong LJ, et al. Chin J Pathophysiol. 1988;22(3):1.
Fu GH, et al. J Harbin Med Univ. 1990;24(5):334.
Xu CQ, et al. J Harbin Med Univ. 1991;25(6):409.
Xu CQ, et al. Chin J Pathophysiol. 1993;9(1):17.
Su XH, Wang XM, et al. Chin J Pathophysiol. 1996;12(2):190.
Xu CQ, et al. Chin J Pathophysiol. 1997;13(1):43.
Ma LY, Gao WD, Wang XM, et al. Chin J Pathophysiol. 1989;5(4):212.
Yue P, et al. Chin J Pathophysiol. 1987;3(3).
Zhu FX, Lui GM, Yang ZH, et al. Chin J Pathophysiol. 1999;15(10):877.
Zhang H, et al. Chin J Pathophysiol. 1993;9(5):561.
Zhu SJ, Wang XM, et al. Chin J Pathophysiol. 1994;10(7 supplement).
Zhu SJ, Wang XM. Chin J Pathophysiol. 1995;11(1).
Ma LY, Wang XM et al. Chin J Pathophysiol. 1993;9(4):485.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Zhu, X. et al. (2015). Effects of Danshen on the Cardiovascular System. In: Yan, X. (eds) Dan Shen (Salvia miltiorrhiza) in Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9463-3_4
Download citation
DOI: https://doi.org/10.1007/978-94-017-9463-3_4
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-9462-6
Online ISBN: 978-94-017-9463-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)