Skip to main content

Studies on the Antibacterial and Anti-inflammatory Actions of Danshen and Its Effects on the Immune System

  • Chapter
  • First Online:
Dan Shen (Salvia miltiorrhiza) in Medicine
  • 759 Accesses

Abstract

Danshen-based Chinese herbal compound formulas or Danshen active component-based preparations are mainly used for the treatment of coronary heart disease and ischemic cerebrovascular disease in clinical practice. They are also used for noncardiovascular and cerebrovascular disease s such as vasculitis, hard skin disease, thromboangiitis obliterans, burn scars, etc., with good efficacy. Danshen medicines have been widely used to treat infectious diseases such as bronchiolitis, asthmatic bronchitis, viral pneumonia, tuberculosis, pleurisy, viral myocarditis, newborn, psoriasis, acne, and others, and the results are satisfactory Zhang (Chin J Clin Pediatr 12(3):959, 2004, [1]). The pharmacological studies on Danshen and its active components are very broad, and the following review focuses on their anti-inflammatory, antibacterial, and immunologic al effects.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Zhang GC. Chin J Clin Pediatr. 2004;12(3):959.

    Google Scholar 

  2. Gao YG, Wong LZ, Tang JX. J Integr Tradit Chin W Med. 1983;3(5):300.

    CAS  Google Scholar 

  3. Gao YG, Song YM, Yang Y, et al. Acta Pharm Sinica. 1979;14(2):75.

    CAS  Google Scholar 

  4. Yan YZ, Chen XY, Zeng WD. J Chin Acad Med Sci. 1986;8(6):417.

    CAS  Google Scholar 

  5. Zhao ZB, Feng JY, Chen SQ, et al. J Sichuan Tradit Chin Med. 1993;11:13.

    Google Scholar 

  6. Lang XC, Li MX, Jia BY, et al. J Hebei Med Coll. 1991;12(3):140.

    Google Scholar 

  7. Ying ZZ, Han ZH, Wu YF. Shizhen J Tradit Chin Med Res. 1994;5(2):19.

    Google Scholar 

  8. Ye HJ, Wang XM, Zhang L, et al. Chin J Clin Hepatol. 1995;11(3):142.

    Google Scholar 

  9. Qu L, Wang D, Yang XL. J Microbiol. 2000;20(2):26, 38.

    Google Scholar 

  10. Sun HM. Tradit Chin Med Res. 199;1(3):50.

    Google Scholar 

  11. Wang P, Wang W, Wang WL, et al. Chin Arch Tradit Chin Med. 2002;20(1):88.

    Google Scholar 

  12. Wang WJ, Wu XZ, Yao Z, et al. Chin J Immunol. 1995;11(6):370.

    Google Scholar 

  13. Zhang LX, Wang M, Qian Y, et al. Pharmacol Clin Chin Materia Medica. 1990;6(4):31.

    Google Scholar 

  14. Jia TY. Tradit Chin Med Res. 1995;8(4):17.

    Google Scholar 

  15. Miao J, Chen J, Gao L. J Tianjin Coll Tradit Chin Med. 1998;17(1):38.

    Google Scholar 

  16. Wang CL, Khara. A, Faber V. J Guangxi Med Univ. 1997;14(3):9.

    Google Scholar 

  17. Lv SJ, Huang HL. Chin J Exp Clin Immunol. 1992;4(2):41.

    Google Scholar 

  18. Liu J, Wu WP, Kuang PG, et al. Chin J Neuroimmunol Neurol. 1998;3(4):225.

    Google Scholar 

  19. Liu J, Kuang PG, Wu WP, et al. Chin J Geriatr Cardiovasc s. 2002;4(2):127.

    Google Scholar 

  20. Lu Q, Sun ZJ. Chin J Crit Care Med. 1999;19(7):389.

    Google Scholar 

  21. Chen KQ, Zhou Y, Xing HY, et al. Chin J Pathophysiol. 1999;15(9):781.

    CAS  Google Scholar 

  22. Gao YY, Wang SF, Zhang ZJ, et al. Chin J Pathophysiol. 1986;2(2):93.

    Google Scholar 

  23. Li H, Tang RY. Acta Pharmacol Sin. 1991;12(3):269.

    CAS  Google Scholar 

  24. Zhou ZC, Zheng JR, Xu WY. J Chin Acad Med Sci. 1997;19(3):232.

    CAS  Google Scholar 

  25. Li LX, Xu ZE, Zhao B. Chin J Histochem Cytochem. 2004;13(2):168.

    CAS  Google Scholar 

  26. Zhang JT, Weiping Wu, Fengying Z, et al. Med J Chin People’s Liberation Army. 2002;27(1):56.

    CAS  Google Scholar 

  27. Wan L, Xu T, Li SS. Chin J Gerontol. 2007;27(3):249.

    Google Scholar 

  28. Nie GL, Guo MJ, Li YP, et al. Chin J Gerontol. 2007;27(9):823.

    Google Scholar 

  29. Wu S, Sheng YL, Jiang ZX, et al. Liaoning J Tradit Chin Med. 2003;30(10):796.

    Google Scholar 

  30. Wu S, Sheng YL, Jiang ZX, et al. China Clin Pract Med. 2007;1(1):4.

    Google Scholar 

  31. Wang XH, Su ZB LL, et al. J Tradit Chin Orthop Traumatol. 2003;15(10):1.

    Google Scholar 

  32. Yang DW, Meng B, Gao LZ, et al. Pract Clin J Integr Tradit Chin W Med. 2007;6:10.

    Google Scholar 

  33. Xu F, Lu BG, Yao Z, et al. Chin Crit Care Med. 1996;8(5):262.

    Google Scholar 

  34. He L, Wang RG, You ZL, et al. J Hunan Univ Tradit Chin Med. 2003;23(2):4.

    Google Scholar 

  35. Liu YL, Chen XY, Chen XL, et al. Tianjin J Tradit Chin Med. 2007;24(1):66.

    Google Scholar 

  36. Wu S, Sheng YL, Jiang ZX, et al. Liaoning J Tradit Chin Med. 2003;30(3):l72.

    Google Scholar 

  37. Yuan WS, Xiong SD, Xu YJ, et al. Hubei J Tradit Chin Med. 2004;26(3):9.

    Google Scholar 

  38. Wang YY, Wu AQ, Xu N, et al. Chin J Mod Appl Pharm. 2003;20(5):343.

    Google Scholar 

  39. Liu JN, Jan H XB. Shenyang J Military Med. 2006;19(1):10.

    Google Scholar 

  40. Jiang KY, Ruan CG, Gu ZL. Acta Acad Med Suzhou. 2000;20(3):203.

    Google Scholar 

  41. Jiang KY, Ruan CG, Gu ZL, et al. Acta Pharmacol Sin. 1998;19(1):47.

    CAS  Google Scholar 

  42. Jiang KY, Gu ZL, Ruan CG. Chin Pharmacol Bull. 2000;16(6):682.

    CAS  Google Scholar 

  43. Zhang FY, Hua SY, Fan YC. J Shandong Univ Tradit Chin Med. 2006;30(2):152.

    Google Scholar 

  44. Jiang KY, Ruan CG, Gu ZL, et al. Acta Pharmacol Sin. 1998;19(1):47.

    CAS  Google Scholar 

  45. Chen YH, Lin SJ, Ku HH, et al. J Cell Biochem. 2001;82(3):512.

    Article  CAS  PubMed  Google Scholar 

  46. Liu J, Kuang PG, Li B, et al. Chin J Neuroimmunol Neurol. 1998;5(2):77.

    Google Scholar 

  47. Liu J, Wu WP, Kuang PG, et al. Chin J Neuroimmunol Neurol. 1998;3(4):225.

    Google Scholar 

  48. Liu J, Kuang PG, Wu WP, et al. Chin J Nerv Mental Dis. 1999;25(4):198.

    CAS  Google Scholar 

  49. Gao CY, Zhou HD, Chen ME, et al. J Apoplexy Nerv Dis. 2001;18(2):113.

    Google Scholar 

  50. Wang L, Huang X, Ding ZH, et al. W China J Pharm Sci. 1995;10(4):193.

    Google Scholar 

  51. Chen X, Zhao Y, Sha JP, et al. J Chengdu Univ Tradit Chin Med. 2002;25(1):42.

    Google Scholar 

  52. Zhao Y, Yin Y, Tian J, et al. J Chengdu Univ Tradit Chin Med. 2003;26(4):33.

    CAS  Google Scholar 

  53. Sha JP, Zhu BD, Xu Y, et al. Chin J Integr Tradit W Med Intensive Crit Care. 2003;10(5):279.

    Google Scholar 

  54. Chen G, Liu RX, Chen XL, et al. J Xi’an Med Univ. 2001;22(5):429.

    CAS  Google Scholar 

  55. Chen G, Liu RX, Fu Jie, et al. J Fourth Mil Med Univ. 2003;24(11):997.

    Google Scholar 

  56. Kuang PG, Liu J, Wang FZ, et al. J Brain Nerv Dis. 1997;5(1):1.

    Google Scholar 

  57. Jiang SJ, Wu WP. Chin J Neurol. 1999;32(5):290.

    Google Scholar 

  58. Miao WN, Dong J, Liu ST, et al. Pharmacol Clin Chin Materia Med. 2003;19(5):24.

    Google Scholar 

  59. Kang BY, Chung SW, Kim SH, et al. Immunopharmacology. 2000;49(3):355.

    Article  CAS  PubMed  Google Scholar 

  60. Kim SY, Moon TC, Chang HW, et al. Phytother Res. 2002;16(7):616.

    Article  CAS  PubMed  Google Scholar 

  61. Ryu SY, Oak MH, Kim KM. Planta Med. 1999;65(7):654.

    Article  CAS  PubMed  Google Scholar 

  62. Liu XR, Guan YJ, Chen KZ, et al. J Shandong Med Univ. 1992;30(1):85.

    Google Scholar 

  63. Sun W, Zhou Y. Chin J Integr Tradit W Nephrol. 2004;5(8):490.

    Google Scholar 

  64. Liu P, Goukou JH, Shenze CS. Pharmacol Clin Chin Materia Med. 1993;9(3):13.

    Google Scholar 

  65. Tang T, Guo WQ, Wang Y, et al. Lett Biotechnol. 2007;18(1):51.

    CAS  Google Scholar 

  66. Lee DS, Lee SH, Noh JG, et al. Biosci Biotechnol Biochem. 1999;63(12):2236.

    Article  CAS  PubMed  Google Scholar 

  67. Wang DB. J Tradit Chin Med. 1982;23(11):846.

    Google Scholar 

  68. Fang QN, Zhang PL, Xu ZP, et al. J Chem. 1976;34(3):197.

    CAS  Google Scholar 

  69. Sun JL, Chang YT, Song HY, et al. Lishizhen Med Materia Med Res. 2003;14(12):725.

    Google Scholar 

  70. Zhang XM, Zhang KR, Hu CQ. Tradit Chin Drug Res Clin Pharmacol. 2003;14(5):321.

    CAS  Google Scholar 

  71. Zhu JR, Luo HW. J China Pharm Coll. 2004;35(4):368.

    CAS  Google Scholar 

  72. Lee D, Lee S, Han S, et al. Bunge Biosci Biotechnol Biochem. 1999;63(12):2236.

    Article  CAS  Google Scholar 

  73. Xu Z, Zhou DR, Wang Y, et al. China J Tradit Chin Med Pharm. 1993;8(5):25.

    Google Scholar 

  74. Luo HW, Gao JW, Zheng JR. J China Pharm Coll. 1988;19(4):258.

    CAS  Google Scholar 

  75. Cui NQ, Zhao EP, Qu C, et al. Chine J Integr Tradit W Med. 1995;1(1):1.

    Google Scholar 

  76. Sun HT, Zhang HG, Zhao XY, et al. Chin Pharm J. 1996;31(4):201.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Guanhua Du or Guanhua Du .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Zhang, L., Du, G. (2015). Studies on the Antibacterial and Anti-inflammatory Actions of Danshen and Its Effects on the Immune System. In: Yan, X. (eds) Dan Shen (Salvia miltiorrhiza) in Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9463-3_11

Download citation

Publish with us

Policies and ethics