Abstract
Glanders, caused by infection with Burkholderia mallei, primarily causes infection in equines, but may be transmitted to humans, and thus qualifies as a true zoonosis. Melioidosis is caused by B. pseudomallei, genetically very similar to B. mallei, but which is an environmental saprophyte capable of infecting humans and a wide range of other animals. Good evidence of animal-to-human, or even human-to-human, transmission of melioidosis is lacking, and so it most appropriately referred to as a sapronosis, or at most a sapro-zoonosis. Although rare in Western countries, both micro-organisms have recently gained much interest because of their potential use as bioterrorism agents . The increasing recognition of melioidosis in humans and recent outbreaks of glanders in animals have led to their description as emerging or re-emerging diseases. Laboratory-associated infections with both organisms have also occurred, resulting in their categorisation as Hazard Group 3 pathogens. In this chapter we review the epidemiology of animal and human cases of glanders and melioidosis, the evidence for different modes of transmission, pathogenesis and clinical features, diagnosis and treatment, as well as public health and disease control issues.
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References
American Society for Microbiology (2008) Sentinel laboratory guidelines for suspected agents of bioterrorism. Burkholderia mallei and B. pseudomallei. http://www.asm.org/images/pdf/BpseudomalleiBmalleiRevision2008.pdf
Al Izzi SA, Al Bassam LS (1989) In vitro susceptibility of Pseudomonas mallei to antimicrobial agents. Comp Immunol Microbiol Infect Dis 12(1–2):5–8
Alibek K, Handelman S (1999) Biohazard. Random House, New York
Abrahamanian FM, Goldstein EJC (2011) Microbiology of animal bite wound infections. Clin Microbiol Rev 24(2):231–246
Alibasoglu M, Yesildere T, Calislar T, Inal T, Calsikan U (1986) Glanders outbreak in lions in the Istanbul zoological garden. Berl Münc Tierärztl Wochenschr 99(2):57–63
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD (2011) Strategies for intracellular survival of Burkholderia pseudomallei. Front Microbiol 2:170
Anuntagool N, Aramsri P, Panichakul T et al (2000) Monoclonal antibody based rapid identification of Burkholderia pseudomallei in blood culture fluid from patients with community-acquired septicaemia. J Med Microbiol 49(12):1075–1078
Amornchai P, Chierakul W, Wuthiekanun V et al (2007) Accuracy of Burkholderia pseudomallei identification using the API 20NE system and a latex agglutination test. J Clin Microbiol 45(11):3774–3776
Boerner P (1882) A preliminary report on work by the imperial health care office leading to discovery of the glanders bacillus. Dtsch Med Wochenschr 52:707–708
Bartlett JG, (1988) Glanders. In Gorbach SL, Bartlett JG, Blacklow NR (eds) Infectious diseases, 2nd edn. Saunders, Philadelpia, pp 1578–1580
Batmanov VP (1991) Sensitivity of pseudomonas mallei to fluoroquinolones and their efficacy in experimental glanders. Antibiot Khimioter 36(9):31–34
Blancou J (1994) Early methods for the surveillance and control of glanders in Europe. Rev Sci Tech 13:545–557
Bernstein JM, Carling ER (1909) Observations on human glanders: with a study of six cases and a discussion of the methods of diagnosis. Br Med J 1(2510):319–325
Baharesefat M, Amjadi AR (1970) Equine melioidosis in Iran. Arch Inst Razi 22:209–213
Burtnick MN, Brett PJ Woods DE (2002) Molecular and physical characterization of Burkholderia mallei O antigens. J Bacteriol 184:849–852
Barbour EK, Nabbut NH, Hamadeh SK, Al-Nakhli HM (1997) Bacterial identity and characteristics in healthy and unhealthy respiratory tracts of sheep and calves.Vet Res Commun 21:421–430
Burtnick MN, DeShazer D, Nair V, Gherardini FC, Brett PJ (2010) Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages. Infect Immun 78(1):88–99
Brett PJ et al (2007) Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human toll-like receptor 4 complexes. Mol Microbiol 63:379–390
Chambon L (1955) Isolement du bacille de Whitmore a partir du milieu exterieur. Ann Inst Pasteur 89:229–235
Chetchotisakd P, Chierakul W, Chaowagul W et al (2014) Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial. Lancet 383:807–814
Currie BJ, Jacups SP (2003) Intensity of rainfall and severity of melioidosis, Australia. Emerg Infect Dis 9:1538–1542
Cheng A, Currie B (2005) Melioidosis: epidemiology, pathophysiology and management. Clin Microbiol Rev 18(2):383–416
Carr Gregory B, Waag D (2007) Glanders. In Dembek ZF (ed) Medical aspects of biological warfare (Chapter 6). Office of the Surgeon General at TMM publications, Walter Reed Army Medical Centre, Washington DC, p 91
Cottew GS, Sutherland AK, Meehan JF (1952) Melioidosis in sheep in Queensland: description of an outbreak. Aust Vet J 28:113–123
Currie BJ, Fisher DA, Anstey NM, Jacups SP (2000) Melioidosis: acute and chronic disease, relapse and reactivation. Trans R Soc Trop Med Hyg 94:301–304
Christopher GW, Cieslak TJ, Pavlin JA, Eitzen EM Jr (1997) Biological warfare. A historical perspective. J Am Med Assoc 278:412–417
Chaowagul W, Simpson AJH, Suputtamongkol Y, White NJ (1999) Empirical cephalosporin treatment of melioidosis. Clin Infect Dis 28:1328
Choy JL, Mayo M, Janmaat A, Currie BJ (2000) Animal melioidosis in Australia. Acta Trop 74:153–158
Cheng AC, Stephens DP, Anstey NM, Currie BJ (2004) Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis. Clin Infect Dis 38:32–37
Currie BJ, Mayo M, Anstey NM, Donohoe P, Haase A, Kemp DJA (2001) Cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates. Am J Trop Med Hyg 65:177–179
Currie BJ, Smith-Vaughan H, Golledge C et al (1994) Pseudomonas pseudomallei isolates collected over 25 years from a non-tropical endemic focus show clonality on the basis of ribotyping. Epidemiol Infect 113:307–312
Currie BJ, Fisher DA, Howard DM et al (2000) The epidemiology of melioidosis in Australia and Papua New Guinea. Acta Trop 74:121–127
Currie BJ, Jacups SP, Cheng AC et al (2004) Melioidosis epidemiology and risk factors from a prospective whole population study in northern Australia. Trop Med Int Health 9:1167–1174
Chaowagul W, Chierakul W, Simpson AJ et al (2005) Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis. Antimicrob Agents Chemother 49:4020–4025
Chierakul W, Anunnatsiri S, Short JM et al (2005) Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis. Clin Infect Dis 41:1105–1113
Currie B, Thomas AD, Godoy D et al. (2007) Australian and Thai isolates of Burkholderia pseudomallei are distinct by multilocus sequence typing: revision of a case of mistaken identity. J Clin Microbiol 45(11):3828–3829
Cheng AC, Limmathurotsakul D, Chierakul W et al (2007) A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand. Clin Infect Dis 45:308–314
Currie BJ, Ward L, Cheng AC (2010) The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4(11):e900. doi:10.1371/journal.pntd.0000900
Dobberstein J (1935) The pathology of central nervous system of horse. Berl Münch Tierärztl Wochenschr 51: 545–546
Dance DAB (1991) Melioidosis: the tip of the iceberg? Clin Microbiol Rev 4:52–60
Dance DAB (2000) Melioidosis as an emerging global problem. Acta Trop 74:115–119
Dance DAB (2000) Ecology of Burkholderia pseudomallei and the interactions between environmental Burkholderia spp. and human-animal hosts. Acta Trop 74:159–168
Derbyshire JB (2002) The eradication of glanders in Canada. Can Vet J 43:722–726
Dodin AS, Galimand M (1986) Naissance, vie et recul d’une maladie infectieuse, la mélioidose en pays tempéré. Arch Inst Pasteur Tunis 63:69–73
Darling RG, Woods JB (2004) USAMRIID’s medical management of biological casualties handbook. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick
DeShazer D, Waag DM, Fritz DL, Woods DE (2001) Identification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridisation and demonstration that the encoded capsule is an essential virulence determinant. Microb Pathog 30:253–269
Dance DAB, King C, Auken H et al (1992) An outbreak of melioidosis in imported primates in Britain. Vet Rec 130:525–529
Fournier J (1965) La mélioidose et le B. de Whitmore. Controverses épidémiologiques et taxonomiques. Bull Soc Pathol Exot Filiales 58:753–765
Glass MB (2009) Comparison of four selective media for the isolation of Burkholderia mallei and Burkholderia pseudomallei. Am J Trop Med Hyg 80:1023–1028
Galimand M, Dodin A (1982) Focus on melioidosis throughout the world. Bull Soc Pathol Exot Filiales 75:375–383
Glass MB, Popovic T (2005) Preliminary evaluation of the API 20NE and RapID NF plus systems for rapid identification of Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol 43:479–483
Godoy D, Randle G, Simpson AJ et al (2003) Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol 41:2068–2079
Howe C, Miller WR (1947) Human glanders: report of six cases. Ann Intern Med 26:93–115
Howard K, Inglis TJ (2005) Disinfection of Burkholderia pseudomallei in potable water. Water Res 39(6):1085–1092
Hu TP, Kung CD, Au BH (1958) Studies on experimental infection of cattle, sheep and goats with glanders bacilli. Acta Vet Zootech Sinica 3:36–43
Hagebock JM, Schlater LK, Frerichs WM, Olson DP (1993) Serological responses to the mallein test for glanders in solipeds. J Vet Diagn Invest 5:97–99
Heine HS, England MJ, Waag DM, Byrne WR (2001) In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and e-test. Antimicrob Agents Chemother 45:2119–2121
Holland DJ, Wesley A, Drinkovic D, Currie BJ (2002) Cystic fibrosis and Burkholderia pseudomallei: an emerging problem? Clin Infect Dis 35:e138–e140
Hornstra H, Pearson T, Georgia S et al (2009) Molecular epidemiology of glanders, Pakistan. Emerg Infect Dis 15:2036–2039
Idris A, Rachmat RFN, Ali SMM (1998) Melioidosis: a case of sheep to human transmission. J Vet Malaysia 10(2):77–79
Inglis TJ, Mee B, Chang B (2001) The environmental microbiology of melioidosis. Rev Med Microbiol 12:13–20
Iliukhin VI, Alekseev VV, Antonov IuV, Savchenko ST, Lozovaia NA (1994) Effectiveness of treatment of experimental glanders after aerogenic infection. Antibiot Khimioter 39(9–10):45–48
Inglis TJ, Garrow SC, Adams C, Henderson M, Mayo M, Currie BJ (1999) Acute melioidosis outbreak in Western Australia. Epidemiol Infect 123:437–443
Jeddeloh JA, Fritz DL, Waag DM, Hartings JM, Andrews GP (2003) Biodefence driven murine model of pneumonic melioidosis. Infect Immun 71:584–587
Kinsley AT (1911) Probable influence of open water troughs in the spread of glanders. J Comp Pathol Ther 40:633–638
Kunakorn M, Jayanetra P, Tanphaichitra P (1991) Man-to-man transmission of melioidosis. Lancet 337:1290–1291
Katz J, Dewald R, Nicholson J (2000) Procedurally similar competitive immunoassay systems for the serodiagnosis of babesia equi, babesia caballi, trypanosoma equiperdum and Burkholderia mallei infection in horses. J Vet Diagn Invest 12:46–50
Kenny DJ, Russell P, Rogers D, Eley SM, Titball RW (1999) In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob Agents Chemother 43:2773–2775
Ketterer PJ, Webster WR, Shield J et al (1986) Melioidosis in intensive piggeries in southeastern Queensland. Aust Vet J 63:146–149
Khan I, Elschner MC, Melzer F et al (2011) Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. Berl Münch Tierärztl Wochenschr 125:117–121
Khan I, Wieler LH, Melzer F et al. (2012) Glanders in animals: a review on epidemiology, clinical presentation, diagnosis and countermeasures. Transbound Emerg Dis 60:204–221
Khaki P, Mosavari N, Khajeh Nasiri S et al (2012) Glanders outbreak at a Tehran Zoo, Iran. Iran J Microbiol 4(1):3–7
Loeffler F (1886) The aetiology of glanders [in German]. Arb Kaiserl Gesundh 1:141–198
Leelarasamee A, Bovornkitti S (1989) Melioidosis: review and update. Rev Infect Dis 11:413–425
Li L, Lu Z, Han O (1994) Epidemiology of melioidosis in China Zhonghua Liu Xing Bing Xue Za Zhi 15:292–295
Lee MA, Wang D, Yap EH (2005) Detection and differentiation of Burkholderia pseudomallei, Burkholderia mallei and Burkholderia thailandensis by multiplex PCR. FEMS Immunol Med Microbiol 43:413–417
Limmathurotsakul D, Wongratanacheewin S, Teerawattanasuk N et al (2010) Increasing Incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82(6):1113–1117
Lipsitz R, Garges S, Aurigemma R et al. (2012) Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and Burkholderia mallei infection, 2010. Emerg Infect Dis 18(12):e12. doi: 10.3201/eid1812.120638. http://wwwnc.cdc.gov/eid/article/18/12/12-0638_article.htm
Limmathurotsakul D, Wuthiekanun V, Wongsuvan G et al (2011) Repeat blood culture positive for Burkholderia pseudomallei indicates an increased risk of death from melioidosis. Am J Trop Med Hygiene 84:858–861
Limmathorotsakul D, Kanoksil M, Wuthiekanun V et al. (2013) Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study. PLoS Negl Trop Dis 7(2):e2072
Minnet FC (1959) Glanders and melioidosis. In Stableforth AW, Galloway IA (eds) Infectious diseases of animals, vol 1. Butterworths Scientific Publications, London, pp 296–309
Mollaret HH (1988) “L’affaire du jardin des plantes” ou comment la mélioidose fit son apparition en France. Med Mal Infect 18:643–654
Miller WR, Pannell L, Kravitz L, Tanner WA, Ingalls MS (1947) Studies on certain biological characteristics of malleomyces mallei and malleomyces pseudomallei. I. morphology, cultivation, viability, and isolation from contaminated specimens. J Bacteriol 55:115–126
McCormick JB, Sexton DJ, McMurray JG, Carey E, Hayes P, Feldman RA (1975) Human-human transmission of pseudomonas pseudomallei. Ann Intern Med 83:512–513
Malik P, Singha H, Khurana SK et al (2012) Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. Vet Ital 48(2):167–178
Nuntayanuwat S, Dharakul T, Chaowagul W, Songsivilai S (1999) Polymorphism in the promoter region of tumour necrosis factor-alpha gene is associated with severe melioidosis. Hum Immunol 60:979–983
Nachaingmai N, Patamasucon P, Tipayamonthein B et al (1985) Pseudomonas pseudomallei in southern Thailand. Southeast Asian J Trop Med Public Health 16:83–87
Nierman WC, DeShazer D, Kim HS et al (2004) Structural flexibility in the Burkholderia mallei genome. Proc Natl Acad Sci USA 101:14246–14251
Neubauer H, Sprague LD, Zacharia R et al (2005) Serodiagnosis of Burkholderia mallei infections in horses: state-of-the-art and perspectives. J Vet Med B Infect Dis Vet Public Health 52:201–205
O’Leary P (1908) Investigations concerning pathogenesis of glanders. Am Vet Rev 33:345–347
Office International des Épizooties—World Organisation for Animal Health (2003) Chapter 2.5.8 Glanders. In: Terrestrial animal health code, 12th edn, pp 259–260
Office International des Épizooties—World Organisation for Animal Health (2011) Handistatus II. Available at http://web.oie.int/hs2/report.asp. Accessed 15 May 2013
Office International des Épizooties - World Organisation for Animal Health (2013) Chapter 2.5.11. Glanders. In OIE Terrestrial Manual. http://www.oie.int/fileadmin/Home/fr/Health_standards/tahm/2.05.11_GLANDERS_FINAL.pdf
Popov SF, Mel’nikov BI, Lagutin MP, Kurilov VI (1991) Capsule formation in the causative agent of glanders. Mikrobiol Zh 53(1):90–92
Robins GD (1906) A study of chronic glanders in man with report of a case: an analysis of 156 cases collected from nature. Studies from the Royal Victoria Hospital Montreal 1:1–98
Rutherford JG (1906) Special report on glanders (from the Veterinary Director-General and Livestock commissioner). F.A. Acland, Ottawa
Rimington RA (1962) Melioidosis in North Queensland. Med J Aust 49(1):50–53
Ribot WJ, Ulrich RL (2006) The animal pathogen-like type III secretion system is required for the intracellular survival of Burkholderia mallei within J774.2 macrophages. Infect Immun 74:4349–4353
Rubin HL, Alexander AD, Yager RH (1963) Melioidosis—a military medical problem? Mil Med 128:538–542
Ralph AJ, McBride J, Currie BJ (2004) Transmission of Burkholderia pseudomallei via breastmilk in northern Australia. Pediatr Infect Dis J 23:1169–1171
Rajchanuvong A, Chaowagul W, Suputtamongkol Y, Smith MD, Dance DAB, White NJ (1995) A prospective comparison of co-amoxiclav and the combination of chloramphenicol, doxycycline, and co-trimoxazole for the oral maintenance treatment of melioidosis. Trans R Soc Trop Med Hyg 89:546–549
Rogul M et al (1970) Nucleic acid similarities among pseudomonas pseudomallei, pseudomonas multivorans, and actinobacillus mallei. J Bacteriol 101:827–835
Russell P, Eley SM, Ellis J et al (2000) Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders. J Antimicrob Chemother 45(6):813–818
Sanford JP (1985) Pseudomonas species (including melioidosis and glanders). In Mandell GL, Douglas RG, Bennett JE (eds) Principles and practice of infectious diseases, 2nd edn. Wiley, New York, pp 1250–1254
Schutz W (1898) A contribution to the subject of glanders. J Comp Pathol Ther 8:1–33
Sharrer GT (1995) The great glanders epizootic, 1861–1866: a Civil War legacy. Agric Hist 69(1):79–97
Stanton AT, Fletcher W (1921) Melioidosis a new disease of the tropics. Trans Fourth Congr Far East Assoc Trop Med 2:196–198
Stanton AT, Fletcher W (1932) Melioidosis: studies from the Institute for Medical Research, Federated Malay States, vol 21. John Bale & Sons and Danielson Ltd, London
Sprague LD, Neubauer H (2004) Melioidosis in animals: a review on epizootiology, diagnosis and clinical presentation. J Vet Med B Infect Dis Vet Public Health 51:305–320
Strauss JM, Groves MG, Mariappan M, Ellison DW (1969) Melioidosis in Malaysia. II. Distribution of pseudomonas pseudomallei in soil and surface water. Am J Trop Med Hygiene 18:698–702
Smith MD, Wuthiekanun V, Walsh AL, White NJ (1996) In vitro activity of carbapenem antibiotics against b-lactam susceptible and resistant strains of Burkholderia pseudomallei. J Antimicrob Chemother 37:611–615
Simpson AJH, Suputtamongkol Y, Smith MD, Angus BJ, Rajanuwong A, Wuthiekanun V, Howe PA, Walsh AL, Chaowagul W, White NJ (1999) Comparison of imipenem and ceftazidime as therapy for severe melioidosis. Clin Infect Dis 29:381–387
Suputtamongkol Y, Hall AJ, Dance DAB et al (1994) The epidemiology of melioidosis in Ubon Ratchatani, northeast Thailand. Int J Epidemiol 23:1082–1090
Srinivasan A, Kraus CN, DeShazer D et al (2001) Glanders in a military research microbiologist. N Engl J Med 345:256–258
Stevens MP, Wood MW, Taylor LA et al (2002) An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen. Mol Microbiol 46(3):649–659
Stevens MP, Haque A, Atkins T et al (2004) Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis. Microbiology 150(8):2669–2676
Stevens MP, Stevens JM, Jeng RL et al (2005) Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei. Mol Microbiol 56(1):40–53
Scholz HC, Joseph M, Tomaso H et al (2006) Detection of the reemerging agent Burkholderia mallei in a recent outbreak of glanders in the United Arab Emirates by a newly developed fliP-based polymerase chain reaction assay. Diagn Microbiol Infect Dis 54(4):241–247
Schell MA, Ulrich RL, Ribot WJ et al (2007) Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol 64:1466–1485
Song H, Hwang J, Yi H et al (2010) The early stage of bacterial genome-reductive evolution in the host. PLoS Pathog 6(5):e1000922
Saquib M, Muhammad G, Naureen A et al (2012) Effectiveness of an antimicrobial treatment scheme in a confined glanders outbreak. BMC Vet Res 8:214
Stoesser N, Pocock J, Moore CE et al (2012) Paediatric suppurative parotitis in Cambodia 2007–2011. Paediatric Infectious Diseases 31(8):865–868
Scott AE, Laws TR, D’Elia RV et al (2013) Protection against experimental melioidosis following immunization with live Burkholderia thailandensis expressing a manno-heptose capsule. Clin Vaccine Immunol 20(7):1041–1047
Thomas AD, Forbes-Faulkner J, Parker M (1979) Isolation of pseudomonas pseudomallei from clay layers at defined depths. Am J Epidemiol 110:515–521
Thomas AD, Norton JH, Forbes-Faulkner JC, Woodland G (1981) Melioidosis in an intensive piggery. Aust Vet J 57:144–145
Thibault FM, Valade E, Vidal DR (2004) Identification and discrimination of Burkholderia pseudomallei, B. mallei, and B. thailandensis by real-time PCR targeting type III secretion system genes. J Clin Microbiol 42:5871–5874
Thin RNT, Groves M, Rapmund G, Mariappan M (1971) Pseudomonas pseudomallei in the surface water of Singapore. Singapore Med J 12:181–182
Thomas AD, Forbes-Faulkner JC, Norton JH, Trueman KF (1988) Clinical and pathological observations on goats experimentally infected with pseudomonas pseudomallei. Aust Vet J 65(2):43–46
Thomas AD, Spinks GA, D’Arcy TL, Norton JH, Trueman KF (1988) Evaluation of four serological tests for the diagnosis of caprine melioidosis. Aust Vet J 65:261–264
Thibault FM, Hernandez E, Vidal DR, Girardet M, Cavallo JD (2004) Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents. J Antimicrob Chemother 54:1134–1138
Ulrich RL, DeShazer D (2004) Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei. Infect Immun 72:1150–1154
Ulrich RL et al (2004) Quorum sensing: a transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei. Infect Immun 72:6589–6596
U’Ren JM, Van Ert MN, Schupp JM et al (2005) Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol 43:5771–5774
Van der Lugt JJ, Henton MM (1995) Melioidosis in a goat. J S Afr Vet Assoc 66:71–73
Whitmore A (1913) An account of a glanders-like disease occurring in Rangoon. J Hyg (Lond) 13:1–34
Whitmore A, Krishnaswami CS (1912) An account of the discovery of a hitherto undescribed infective disease occurring among the population of Rangoon. Indian Med Gazette 47:262–267
Worley G, Young G (1945) The glanders organism with reference to cell inclusion. J Bacteriol 49:97–100
Wernery R, Kinne J, Haydn-Evans J, Ul-Haq A (1997) Melioidosis in a seven year old camel, a new disease in the United Arab Emirates. J Camel Res 4:141–143
White NJ, Dance DA, Chaowagul W, Wattanagoon Y, Wuthiekanun V, Pitakwatchara N (1989) Halving of mortality of severe melioidosis by Ceftazidime. Lancet 23:697–701
Wuthiekanun V, Amornchai P, Chierakul W et al (2004) Evaluation of immunoglobulin M (IgM) and IgG rapid cassette test kits for diagnosis of melioidosis in an area of endemnicity. J Clin Micro 42:3435–3437
Wuthiekanun V, Desakorn V, Wonsuwan G et al (2005) Rapid immunofluorescence microscopy for diagnosis of melioidosis. Clin Diag Lab Immunol 12:555–556
Wuthiekanun V, Chierakul W, Langla S et al (2006) Development of antibodies to Burkholderia pseudomallei during childhood in melioidosis-endemic northeast Thailand. Am J Trop Med Hygiene 74:1074–1075
Wittig MB, Wohlsein P, Hagen RM et al. (2006). Glanders—a comprehensive review. Dtsch Tierärztl Wochenschr 113:323–330
Wernery U, Wernery R, Joseph M et al (2011) Natural Burkholderia mallei infection in a dromedary. Bahrain Emerg Infect Dis 7:1277–1279
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Fhogartaigh, C., Dance, D. (2015). Glanders & Melioidosis: A Zoonosis and a Sapronosis—“Same Same, but Different”. In: Sing, A. (eds) Zoonoses - Infections Affecting Humans and Animals. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9457-2_35
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